A5081368178- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Congenital heart defects research
- Hepatitis B Virus Studies
- Gastrointestinal motility and disorders
- Pharmacological Effects of Natural Compounds
- Cardiac Fibrosis and Remodeling
- Mycobacterium research and diagnosis
- Pathogenesis and Treatment of Hiccups
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Liver physiology and pathology
- Gastroesophageal reflux and treatments
- Inflammatory mediators and NSAID effects
- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Studies
- Tryptophan and brain disorders
- Complementary and Alternative Medicine Studies
- Hepatitis C virus research
- Gastric Cancer Management and Outcomes
- Galectins and Cancer Biology
- Pluripotent Stem Cells Research
- Inflammatory Bowel Disease
- Chromatin Remodeling and Cancer
- Genetics and Neurodevelopmental Disorders
Guangzhou University of Chinese Medicine
2016-2025
Shuguang Hospital
2022-2023
Shanghai University of Traditional Chinese Medicine
2022-2023
Clemson University
2014-2023
Shanghai Jiao Tong University
2013-2014
The inverse F-BAR (IF-BAR) domain proteins srGAP1, srGAP2 and srGAP3 are implicated in neuronal development may be linked to mental retardation, schizophrenia seizure. A partially overlapping expression pattern highly similar protein structures indicate a functional redundancy of srGAPs development. Our previous study suggests that negatively regulates differentiation Rac1-dependent manner mouse Neuro2a cells. Here we show exogenously expressed srGAP1 sufficient inhibit valporic acid...
E-cadherin, encoded by the CDH1 gene, plays an essential role in epithelial cellular adhesion, and loss of it has been reported to be associated with tumor progression metastasis, potentially offer a glimpse development colorectal cancer. The present study aimed explore effect CDH1-160 polymorphism, transcription its protein E-cadherin expression on cancer, meanwhile uncovering underlying mechanism. Specimens from cancer loci, adjacent tissue, distal normal tissue patients were collected for...
Background This study investigates the role of CDH1 gene single nucleotide polymorphisms (SNPs), mRNA transcription levels, and E-cadherin protein localization in Helicobacter pylori (Hp)-associated gastric diseases their contribution to mucosal carcinogenesis. Methods Gastric samples were analyzed for histopathology (Hematoxylin-Eosin staining) Hp detection (rapid urease test, Giemsa staining). SNPs at rs16260 locus identified via sequencing, levels quantified by real-time PCR, was assessed...
Objectives: To analyze the research hotspots, evolution, and trends of treatment liver fibrosis in recent 20 years, bibliometric knowledge-map analysis were used. Methods: Publications associated with retrieved from Web Science Core Collection on 16 April 2022. CiteSpace 5.8.R3 VOSviewer 1.6.18 calculated to perform analysis. Results: A total 72,686 authors 200 institutions 134 countries/regions published 15,237 studies different academic journals. United States was most productive country,...
In vivo, cardiomyocytes comprise a heterogeneous population of contractile cells defined by unique electrophysiologies, molecular markers and morphologies. The mechanisms directing myocardial to specific sub-lineages remain poorly understood. Here we report that overexpression TGFβ-Activated Kinase (TAK1/Map3k7) in mouse embryonic stem (ES) faithfully directs differentiation embryoid body (EB)-derived cardiac toward the sinoatrial node (SAN) lineage. Most Map3k7-overexpressing EBs adopt...
Although nonpharmacological interventions (NPI) for irritable bowel syndrome (IBS) have been applied clinically, their relative efficacy and safety are poorly understood.
Plenty of clinical studies have suggested the value Chinese herbal medicine (CHM) for patients with irritable bowel syndrome (IBS), but their efficacy and safety not been systematically concluded yet. This article aimed to compare rank therapeutic effect CHM routine pharmacotherapies placebo in treatment IBS.Randomized controlled trials regarding treat IBS were searched six databases from inception Jan 31, 2020. A network meta-analysis was conducted analyze data included publications. The...
Objectives: The study aims to explore the most influential countries, institutions, journals, authors, "research hotspots," and trends in of mechanism liver regeneration (MoLR) last 20 years using bibliometric analyses. Methods: literature associated with MoLR was retrieved from Web Science Core Collection on 11 October 2022. CiteSpace 6.1.R6 (64-bit) VOSviewer 1.6.18 were used for Results: A total 18,956 authors 2,900 institutions 71 countries/regions published 3,563 studies different...
Specification of the primary heart field in mouse embryos requires signaling from anterior visceral endoderm (AVE). The nature these signals is not known. We hypothesized that TGFβ-activated kinase (TAK1/Map3k7) may act as a cardiogenic factor, based on its expression heart-inducing and requirement for cardiac differentiation p19 cells. To test this, embryonic stem (ES) cells overexpressing Map3k7 were isolated differentiated embryoid bodies (EBs). Map3k7-overexpressing EBs showed increased...
Background:Helicobacter pylori (Hp) persistent infection is an important pathogenic factor for a series of chronic gastric diseases from gastritis to cancer. Genetic and epigenetic abnormalities microRNAs may play vital role in the pathological evolution mucosa Helicobacter pylori-related (HPGD). This study aimed investigate relationship between miR-146a, miR-196a2, miR-149, miR-499 miR-27a gene single nucleotide polymorphisms (SNPs) their expressions with changes mucosa, further analyze...
Genetic studies place Tbx5 at the apex of sinoatrial node (SAN) transcriptional program. To understand its role in SAN differentiation, clonal embryonic stem (ES) cell lines were made that conditionally overexpress Tbx5, Tbx3, Tbx18, Shox2, Islet-1, and MAP3k7/TAK1. Cardiac cells differentiated using embryoid bodies (EBs). EBs overexpressing Islet1, TAK1 beat faster than cardiac from control ES lines, suggesting possible roles differentiation. showed increased expression TAK1, but...
After receiving entecavir or combined with FuzhengHuayu tablet (FZHY) treatment, some sufferers hepatitis B virus (HBV)-related liver fibrosis could achieve a histological improvement while the others may fail to improve even worsen. Serum metabolomics at baseline in these patients who were effective treatment remain unclear.To explore serum metabolites characteristics responders.A total of 132 HBV-related and 18 volunteers as healthy controls recruited. First, all subjects divided into...
Background and aims: The serum metabolites changes in patients with hepatitis B virus (HBV)-related cirrhosis as progression. Peroxisome proliferator-activated receptor gamma (PPARγ) is closely related to lipid metabolism cirrhotic liver. However, the relationship between fatty acids expression of hepatic PPARγ during regression remains unknown. In this study, we explored metabolic characteristics histological response treatment entecavir. Methods: Sixty HBV-related were selected training...