A5042422947- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Diagnosis and treatment of tuberculosis
- Drug-Induced Hepatotoxicity and Protection
- Pharmaceutical studies and practices
- Infectious Diseases and Tuberculosis
- Pharmaceutical Practices and Patient Outcomes
University Medical Center Groningen
2016-2022
University of Groningen
2016-2022
Public Health Service of Amsterdam
2016-2020
GGD Haaglanden
2016-2017
BACKGROUND: Optimal drug dosing is important to ensure adequate response treatment, prevent development of resistance and reduce toxicity. The aim these clinical standards provide guidance on 'best practice´ for management TB drugs.METHODS: A panel 57 global experts in the fields microbiology, pharmacology care were identified; 51 participated a Delphi process. 5-point Likert scale was used score draft standards. final document represents broad consensus approved by all participants.RESULTS:...
Since in low incidence TB countries population migration and complex treatment of drug-resistant tuberculosis (DR-TB) patients are major issues, we aimed to analyse patient risk factors associated with the poor outcome among DR-TB Netherlands. This retrospective cohort study included adult confirmed treated from 2005 2015. We obtained data a nationwide exhaustive registry Predictors for unsuccessful (defaulted failed treatment) TB-associated mortality were analysed using multivariate...
Pharmacodynamics are especially important in the treatment of multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB). The free area under concentration time curve relation to MIC (fAUC/MIC) is most relevant pharmacokinetic (PK)-pharmacodynamic (PD) parameter for predicting efficacy levofloxacin (LFX). objective our study was assess LFX PK variability M/XDR-TB patients its potential consequence fAUC/MIC ratios. Patients with pulmonary received as part regimen at a dose 15 mg/kg...
As a vulnerable population, children and adolescents with tuberculosis (TB) are faced many challenges, even those who live in low TB incidence countries. We aimed to evaluate factors associated treatment outcomes allowing more focused interventions support this population once diagnosed.A retrospective cohort study using nationwide surveillance database was performed (aged 0-18 years) treated for the Netherlands from 1993 2018. Logistic regression analyses were used estimate adjusted odds...
Standard treatment duration for drug-susceptible tuberculosis (TB) is 6 months. Treatment often extended-and various different reasons. The aim of this study was to determine the prevalence and assess risk factors associated with extended TB treatment.A cross-sectional conducted. Data including demographic, clinical, radiological microbiological information from Netherlands Register (NTR) 90 patients smear culture positive pulmonary region Haaglanden, Netherlands, eligible analysis.Treatment...
Background Tuberculosis (TB) in children and adolescents is a sentinel event for ongoing transmission. In the Netherlands, epidemiological characteristics of childhood adolescent TB have not been fully evaluated. Therefore, we aimed to assess epidemiology within this population provide guidance elimination. Methods A retrospective time-series analysis using national surveillance data from 1993–2018 was performed (aged <15 years) 15–19 with TB. Poisson regression models offset...