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A5117794420The spatial organisation of RNA condensates is fundamental for understanding basic cellular functions, but may also provide pivotal insights into diseases. One the major challenges to role lack technologies map condensate-scale protein architecture at subcompartmental or nanoscale resolution. To address this, we introduce HCR-Proxy, a proximity labelling technique that couples Hybridization Chain Reaction (HCR)-based signal amplification with in situ biotinylation (Proxy), enabling proteomic...
10.1101/2025.05.30.656369
preprint
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cc-by
bioRxiv (Cold Spring Harbor Laboratory)
2025-05-31
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