A5098058004- Platelet Disorders and Treatments
- Respiratory viral infections research
- Immunodeficiency and Autoimmune Disorders
- Iron Metabolism and Disorders
- Hemophilia Treatment and Research
- Adolescent and Pediatric Healthcare
- Hemostasis and retained surgical items
- Hemoglobinopathies and Related Disorders
- Pleural and Pulmonary Diseases
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Vitamin D Research Studies
- Pneumonia and Respiratory Infections
- Gastrointestinal Tumor Research and Treatment
- Lipid metabolism and disorders
- Autoimmune and Inflammatory Disorders Research
Ain Shams University Hospital
2024
Uniwersytecki Szpital Dziecięcy
2024
Children's Clinical University Hospital
2024
Ain Shams University
2024
Abstract Background and Objectives Immune thrombocytopenia (ITP) is a relatively frequent acquired bleeding disorders. Etiology not yet well understood. Lymphocytic function associated antigen-1(LFA-1) might play an important role in signal coordination lymphocyte activation. The aim of this study was to assess CD11a expression on lymphocytes newly diagnosed ITP patients correlate it with severity evaluate the effect immunomodulation medications children ITP. Patients Methods This...
Abstract Background Familial hemophagocytic lymphohistiocytosis (HLH) results in clinical manifestations of an extreme inflammatory process; leading to overlap with other diseases a hyperinflammation process. Implementing HLH criteria without genetic analysis might lead inadvertent planned therapy immunosuppressive and unnecessary bone marrow transplantation. Objectives This study assessed the frequency types UNCD mutations among patients clinically diagnosed or systemic response syndrome...
Background: Autoimmune diseases might be linked to changes in gut microbiota. We studied microbiota pattern newly diagnosed Idiopathic Thrombocytopenia (N-ITP) report possible alteration of N-ITP and impact on disease course. Methods: Fifty children with aged 2-15 years 30 control were assessed, for 7 specific genera stool using real time PCR within the 1st week presentation prior therapy. Bleeding assessment tool CBC done initially, followed-up regularly 3 months. Results: Most cases had...
Background Vitamin D deficiency (VDD) is a common nutritional burden among children with sickle cell disease (SCD). Aims To measure VD levels in SCD and to assess the safety efficacy of its supplementation on clinical outcomes. Patients methods This follow-up prospective study recruited 50 adolescents at their steady state. were clinically assessed had complete blood count, liver kidney function tests, serum ferritin, 25-hydroxyvitamin level assessed. VDD treated oral (6000 units daily) for...
Background Females with rare bleeding disorders who suffer from mild symptoms and extra related to menstruation are usually delayed in their diagnosis, necessitating early evaluation for an underlying diathesis based on clinical suspicion. Objectives We aimed assess the frequency of among female children adolescents presenting evaluate health-related quality life. Patients methods Sixty females younger than 18 years old were recruited subjected detailed medical assessment different using...
Objective To examine the spectrum of pathogens and outcome severe acute respiratory infections (SARIs) among admitted children with hematology/oncology disorders who presented SARIs in low-middle income countries. Patients methods The prospective observation study recruited 52 children, clinically assessed, their nasopharyngeal oropharyngeal swabs were examined analyzed by real-time multiplex PCR. Results 27 females 25 males, mean age 5.2 ± 2.9 years, 36 (69.2%) had pediatric malignancies,...