A5022100327- Sarcoma Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Genomics and Chromatin Dynamics
- Congenital heart defects research
- Epigenetics and DNA Methylation
Institut Jacques Monod
2020
Université Paris Cité
2020
Centre National de la Recherche Scientifique
2020
The chromosome translocations generating PAX3-FOXO1 and PAX7-FOXO1 chimeric proteins are the primary hallmarks of paediatric fusion-positive alveolar subtype Rhabdomyosarcoma (FP-RMS). Despite ability these transcription factors to remodel chromatin landscapes promote expression tumour driver genes, they only inefficiently malignant transformation in vivo . reason for this is unclear. To address this, we developed an ovo model follow response spinal cord progenitors PAX-FOXO1s. Our data...
Abstract The chromosome translocations generating PAX3FOXO1 and PAX7FOXO1 chimeric proteins are the primary hallmarks of paediatric cancer, Alveolar Rhabdomyosarcoma (ARMS). Despite ability these transcription factors to remodel chromatin landscapes promote expression tumour driver genes, they only inefficiently malignant transformation in vivo . reason for this is unclear. To address this, we developed an ovo model follow response spinal cord progenitors PAXFOXO1s. Our data demonstrate that...