A5013007784- Axon Guidance and Neuronal Signaling
- Phagocytosis and Immune Regulation
- Neuroblastoma Research and Treatments
- Immune cells in cancer
- Adenosine and Purinergic Signaling
- Tryptophan and brain disorders
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Polyamine Metabolism and Applications
- S100 Proteins and Annexins
- HIV Research and Treatment
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Parkinson's Disease Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Reproductive System and Pregnancy
- Bone Tissue Engineering Materials
- Neuroendocrine regulation and behavior
- Silk-based biomaterials and applications
- Toxoplasma gondii Research Studies
- Hedgehog Signaling Pathway Studies
- Neurogenesis and neuroplasticity mechanisms
- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
Università Cattolica del Sacro Cuore
2021-2025
Agostino Gemelli University Polyclinic
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Roma Tre University
2014-2019
Previously, we reported that HIV-Tat elicits spermine oxidase (SMO) activity upregulation through NMDA receptor (NMDAR) stimulation in human SH-SY5Y neuroblastoma cells, thus increasing ROS generation, which turn leads to GSH depletion, oxidative stress, and reduced cell viability. In several types, can trigger an antioxidant response the transcriptional induction of stress-responsive genes regulated by nuclear factor erythroid 2-related 2 (Nrf2). Here, demonstrate Tat induces both gene...
Neuropilin-1 (NRP1) is a transmembrane protein involved in surface receptor complexes for variety of extracellular signals. NRP1 expression human cancers associated with prominent angiogenesis and advanced progression stage. However, the molecular mechanisms underlying activity tumor microenvironment remain unclear. Notably, diffusible forms space have been reported, but their functional role poorly understood. Extracellular vesicles (EV) were isolated from conditioned media diverse cancer...
The pathogenic mechanisms that underlie the progression of remote degeneration after spinal cord injury (SCI) are not fully understood. In this study, we examined relationship between endoplasmic reticulum (ER) stress and macroautophagy, hereafter autophagy, its contribution to secondary damage outcomes associated with SCI. Using a rat model hemisection at cervical level, measured ER autophagy markers in axotomized neurons red nucleus (RN). SCI animals, mRNA protein levels stress, such as...
Abstract Cytotoxic T cell (CTL) infiltration of the tumor carries potential to limit cancer progression, but their exclusion by immunosuppressive microenvironment hampers efficiency immunotherapy. Here, we show that expression axon guidance molecule Plexin-A4 (Plxna4) in CTLs, especially effector/memory CD8+ cells, is induced upon T-cell activation, sustained circulation, reduced when entering bed. Therefore, deleted Plxna4 and observed Plxna4-deficient CTLs acquired improved homing capacity...
Abstract Semaphorin–plexin signaling plays a major role in the tumor microenvironment (TME). In particular, Semaphorin 4D (SEMA4D) has been shown to promote growth and metastasis; however, of its high-affinity receptor Plexin-B1 (PLXNB1), which is expressed TME, poorly understood. this study, we directly targeted PLXNB1 TME triple-negative murine breast carcinoma elucidate relevance cancer progression. We found that primary metastatic dissemination were strongly reduced PLXNB1-deficient...
Abstract The genetic changes sustaining the development of cancers unknown primary (CUP) remain elusive. whole‐exome genomic profiling 14 rigorously selected CUP samples did not reveal specific recurring mutation in known driver genes. However, by comparing mutational landscape CUPs with that most other human tumor types, it emerged a consistent enrichment genes belonging to axon guidance KEGG pathway. In particular, G842C PlexinB2 (PlxnB2) was predicted be activating. Indeed, knocking down...
In the field of tissue engineering, recombinant protein-based biomaterials made up block polypeptides with tunable properties arising from functionalities individual domains are appealing candidates for construction medical devices. this work, we focused our attention on preparation and structural characterization nanofibers a chimeric-polypeptide-containing resilin elastin domain, designed purpose to enhance its cell-binding ability by introducing specific fibronectin-derived Arg-Gly-Asp...
<div>Abstract<p>Semaphorin–plexin signaling plays a major role in the tumor microenvironment (TME). In particular, Semaphorin 4D (SEMA4D) has been shown to promote growth and metastasis; however, of its high-affinity receptor Plexin-B1 (PLXNB1), which is expressed TME, poorly understood. this study, we directly targeted PLXNB1 TME triple-negative murine breast carcinoma elucidate relevance cancer progression. We found that primary metastatic dissemination were strongly reduced...
<p>The treatment with Fc(m6A9)B3 PLXNB1 inhibitor decreases M2-like macrophages and enhances the number of CD8+ GrzB+ T-cells in Py230 model</p>
<p>PLXNB1 depletion induces an activated phenotype in TILs and T-cells vitro enhances CD8+ recruitment lung metastasis 4T1 model</p>
<p>PLXNB1 depletion induces higher number of infiltrating macrophages in 4T1 tumors and a shift toward M1 gene polarization ex-vivo models.</p>
<p>PLXNB1 depletion induces tumor vessel normalization and reduces hypoxia</p>
<p>PLXNB1 inhibition does not affect 4T1 cells extravasation to the lung and their ability adhere endothelial cells</p>
<p>PLXNB1 inhibition did not directly affect tumor cells both in vitro and vivo EMT6 TNBC mouse model</p>
<div>Abstract<p>Semaphorin–plexin signaling plays a major role in the tumor microenvironment (TME). In particular, Semaphorin 4D (SEMA4D) has been shown to promote growth and metastasis; however, of its high-affinity receptor Plexin-B1 (PLXNB1), which is expressed TME, poorly understood. this study, we directly targeted PLXNB1 TME triple-negative murine breast carcinoma elucidate relevance cancer progression. We found that primary metastatic dissemination were strongly reduced...
<p>PLXNB1 depletion induces tumor vessel normalization and reduces hypoxia</p>
<p>PLXNB1 depletion induces an activated phenotype in TILs and T-cells vitro enhances CD8+ recruitment lung metastasis 4T1 model</p>