A5067404890- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
- Diabetes Treatment and Management
- Polydiacetylene-based materials and applications
- Antimicrobial Peptides and Activities
- 3D Printing in Biomedical Research
- Invertebrate Immune Response Mechanisms
- Photochromic and Fluorescence Chemistry
- Parasites and Host Interactions
- Systemic Sclerosis and Related Diseases
- Photopolymerization techniques and applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Natural Antidiabetic Agents Studies
- Angiogenesis and VEGF in Cancer
- Apelin-related biomedical research
- Mast cells and histamine
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Eosinophilic Disorders and Syndromes
University of Zurich
2021-2024
University Hospital of Zurich
2018-2022
University of Copenhagen
2016
Neutrophils are the first nonresident effector immune cells that migrate to a site of infection or inflammation; however, improper control neutrophil responses can cause considerable tissue damage. Here, we found in inflamed infected skin were regulated by CCR7-dependent migration and phagocytosis neutrophils draining lymph nodes (dLNs). In mouse models Toll-like receptor-induced inflammation cutaneous Staphylococcus aureus infection, migrated from dLNs via lymphatic vessels CCR7-mediated...
Abstract Background Systemic sclerosis (SSc) is a multiorgan autoimmune disease characterized by inflammation, vascular modification, and progressive fibrosis of the skin several visceral organs. Innate adaptive immune cells, including myeloid, B T are believed to be central pathogenesis SSc. However, role functional state neutrophil granulocytes (neutrophils) ill‐defined in Methods We performed prospective study neutrophils freshly isolated from SSc patients healthy donors (HD) measuring...
Atopic individuals show enhanced type 2 immune cell responses and a susceptibility to infections with certain bacteria viruses. Although patients allergic diseases harbor normal counts of circulating neutrophils, these cells exert deficient effector functions. However, the underlying mechanism this dysregulation neutrophils remains ill defined. Here, we find that development, aging, elimination are accelerated in mice predisposition immunity, which, turn, causes infection several bacteria....
Interleukin-4 (IL-4) is a cytokine that plays central role in type 2 immune responses and involved regulating pleiotropic actions our body by engaging multiple different IL-4 receptor (IL-4R) complexes. Targeting the IL-4R system has high potential for therapeutic intervention allergic autoimmune diseases. A challenge developing this clinical application construction of variants tailored engagement with specific subunits, which are necessary selective activation signaling pathways to treat...
We investigated the acute effects of glucagon-like peptide-1 (GLP-1), GLP-1(1–36), and GLP-1(7–36) on vascular endothelial growth factor-A (VEGFA)-induced endothelium-dependent signaling vasodilation. Our hypothesis was that GLP-1 released from intestinal l-cells modulates processes related to PLCγ activation, Src, NOS (eNOS) signaling, thereby controlling vessel tone. By using RT-PCR analysis, we found mRNA for receptor (GLP-1R) in human dermal microvascular cells (HDMEC), retinal cells,...
Regulation of neutrophil chemotaxis and activation plays crucial roles in immunity, dysregulated responses can lead to pathology as seen neutrophilic asthma. Neutrophil recruitment is key for initiating immune defense inflammation, its modulation a promising therapeutic target. Microfluidic technology an attractive tool characterization migration. Compared transwell assays, microfluidic approaches could offer several advantages, including precis e control defined chemokine gradients space...
The incretine GLP‐1 enhances insulin release and thereby causes a diminished blood glucose peak in response to food intake. We explored the potential roles of vascular function by studying signaling human dermal microvascular endothelial cells (HDMEC), retinal (HRMEC) rat mesenteric resistance arteries. found that HDMEC, HRMEC vessels express GLP‐1R use RT‐PCR. GLP‐1, on its own, induced phosphorylation Src ERK 1/2. By Ca 2+ imaging we pre‐incubation for 15 min with caused reduction VEGF‐A...
Abstract A rapid neutrophil response is essential for immunity against infections, however impaired elimination or migration can inflict significant tissue damage by exacerbated inflammation. Here we show that neutrophils recruited to inflamed infected skin are rapidly redirected skin-draining lymph nodes (dLNs) and non-draining secondary lymphoid tissues. Using transgenic mouse models bone marrow chimeras, cutaneous inflammation induced with imiquimod, a TLR7-mediated psoriasis-like model,...