A5029293458- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Biosensors and Analytical Detection
- Respiratory viral infections research
GGD Rotterdam-Rijnmond
2021-2022
To assess the performance of rapid antigen tests with unsupervised nasal and combined oropharyngeal self-sampling during omicron period.Prospective cross sectional diagnostic test accuracy study.Three public health service covid-19 sites in Netherlands, 21 December 2021 to 10 February 2022.6497 people symptoms aged ≥16 years presenting for testing.Participants had a swab sample taken reverse transcription polymerase chain reaction (RT-PCR, reference test) received one perform using either...
Abstract Background The diagnostic accuracy of unsupervised self-testing with rapid antigen tests (Ag-RDTs) is mostly unknown. We studied the a self-performed SARS-CoV-2 saliva and nasal Ag-RDT in general population. Methods This large cross-sectional study consecutively included unselected individuals aged $$\ge$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mo>≥</mml:mo> </mml:math> 16 years presenting for testing at three public health service test sites. Participants...
To assess the performances of three commonly used antigen rapid diagnostic tests as self-tests in asymptomatic individuals Omicron period.We performed a cross-sectional test accuracy study period public health service COVID-19 sites Netherlands, including 3600 aged ≥ 16 years presenting for SARS-CoV-2 testing any reason except confirmatory after positive self-test. Participants were sampled RT-PCR (reference test) and received one self-test (either Acon Flowflex [Flowflex], MP Biomedicals...
Rapid antigen diagnostic tests (Ag-RDTs) are the most widely used point-of-care for detecting SARS-CoV-2 infection. Since accuracy may have altered by changes in epidemiology, indications testing, sampling and testing procedures, roll-out of COVID-19 vaccination, we evaluated performance three prevailing Ag-RDTs.
Abstract Background SARS-CoV-2 self-tests may lower the threshold of testing and produce a result quickly. This could support early detection infectious cases reduce further community transmission. However, diagnostic accuracy (unsupervised) self-testing with rapid antigen tests (Ag-RDTs) is mostly unknown. We therefore conducted large-scale head-to-head comparison self-performed saliva nasal Ag-RDT, each compared to molecular reference test, in general population Netherlands. Methods In...
Abstract Objective To assess the diagnostic accuracy of three rapid antigen tests (Ag-RDTs) for detecting SARS-CoV-2 infection in general population. Design Cross-sectional study with follow-up using pseudonymised record linkage. Setting Three Dutch public health service COVID-19 test sites. Participants Consecutively included individuals aged 16 years and older presenting testing. Main outcome measures Sensitivity, specificity, positive negative predictive values BD-Veritor tm System...
Abstract Background Performances of rapid antigen diagnostic tests (Ag-RDTs) with nasal self-sampling, and oropharyngeal plus (OP-N) in the Omicron period are unknown. Methods Prospective accuracy study among 6,497 symptomatic individuals aged >16 years presenting for SARS-CoV-2 testing at three test-sites. Participants were sampled RT-PCR (reference test) received one Ag-RDT to perform unsupervised either self-sampling (during emergence Omicron, after share was >90%, phase-1) or OP-N...
Abstract Objectives To assess the performances of three commonly used rapid antigen diagnostic tests (Ag-RDTs) as self-tests in asymptomatic individuals Omicron period. Design Cross-sectional test accuracy study. Setting Three public health service COVID-19 sites Netherlands. Participants 3,600 aged ≥16 years presenting for SARS-CoV-2 testing any reason except confirmatory after a positive self-test. Interventions were sampled RT-PCR (reference test) and received one self-test (either Acon...