A5066152699- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cardiac tumors and thrombi
- Neuroblastoma Research and Treatments
- Vascular Tumors and Angiosarcomas
- Soft tissue tumors and treatment
- Gastrointestinal Tumor Research and Treatment
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
- Cancer Cells and Metastasis
- Spinal Hematomas and Complications
- Lymphoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Signaling Pathways in Disease
- Cancer Research and Treatments
- Metastasis and carcinoma case studies
- Nerve injury and regeneration
- Tumors and Oncological Cases
- Histone Deacetylase Inhibitors Research
- CAR-T cell therapy research
- Silk-based biomaterials and applications
- Virus-based gene therapy research
The University of Texas MD Anderson Cancer Center
2016-2025
Scripps MD Anderson Cancer Center
2011-2024
Sarcoma Oncology Center
2011-2023
Methodist Hospital
2021
Houston Methodist
2021
Anesthesiology and Surgical Oncology Research Group
2016-2020
The University of Texas Health Science Center at Houston
2015-2017
Society of Surgical Oncology
2003-2016
GenUs BioSystems (United States)
2015
Massachusetts General Hospital
2015
Expression of strong nuclear STAT6 is thought to be a specific marker for solitary fibrous tumors (SFTs). Little known about subtle expression patterns in other mesenchymal lesions.We performed immunohistochemical studies against the C-terminus tissue microarrays and whole sections, comprising 2366 lesions.Strong was expressed 285 2,021 tumors, including 206 240 SFTs, 49 408 well-differentiated/dedifferentiated liposarcomas, eight 65 unclassified sarcomas, 14 184 desmoid among others. SFTs...
<h3>Importance</h3> Neurofibromatosis type 1 (NF1) is a complex genetic disorder that associated with not only neurofibromas, but also an increased susceptibility to other neoplasms. <h3>Objective</h3> To evaluate the prevalence of neoplasia and outcomes among patients NF1. <h3>Design, Setting, Participants</h3> This cohort study was conducted NF1 at single academic cancer center from 1985 2020 median (range) follow-up 2.9 years (36 days 30.5 years). Of 2427 evaluated for NF1, 1607 who met...
Background Vimentin is a ubiquitous mesenchymal intermediate filament supporting mechano-structural integrity of quiescent cells while participating in adhesion, migration, survival, and cell signaling processes via dynamic assembly/disassembly activated cells. Soft tissue sarcomas some epithelial cancers exhibiting "epithelial to transition" phenotypes express vimentin. Withaferin-A, naturally derived bioactive compound, may molecularly target vimentin, so we sought evaluate its effects on...
Abstract To date, no specific marker exists for the detection of circulating tumor cells (CTC) from different types sarcomas, though tools are available CTCs in peripheral blood patients with cancer epithelial cancers. Here, we report cell-surface vimentin (CSV) as an exclusive on sarcoma CTC regardless tissue origin detected by a novel monoclonal antibody. Utilizing CSV probe, isolated and enumerated high sensitivity specificity bearing sarcoma, validating their phenotype single cell...
Retroperitoneal sarcomas (RPS) are rare tumors for which complete surgical resection remains the mainstay of treatment. The objective current study was to determine impact hospital case volume on outcomes in patients with RPS.A total 6950 primary RPS who underwent were identified from National Cancer Data Base (1998-2011). Treating hospitals classified by annual volume; low-volume (LVHs) and high-volume (HVHs) defined as those ≤10 cases per year >10 year, respectively. Overall survival (OS)...
BACKGROUND: Pleomorphic liposarcoma (PLS) is a rare high-grade sarcoma that has lipoblastic differentiation. In this study, the authors evaluated PLS natural history, patient outcomes, and commonly deregulated protein biomarkers. METHODS: Medical records from patients (n = 155) who had 1993 to 2010 were reviewed. Univariate multivariate analyses conducted identify independent prognosticators. A tissue microarray (TMA) 56 specimens) was constructed for immunohistochemical analysis of...
OBJECTIVE Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive group of soft tissue sarcomas that can arise sporadically, in the context neurofibromatosis Type 1 (NF1) or at a site prior irradiation. Large series profiling features and outcomes sporadic, NF1-associated, radiation-associated MPNSTs limited. The goal this study was to elucidate differences between MPNST etiologies large single-institution retrospective study. METHODS Patients (n = 317) were identified through...
Soft tissue sarcomas are a heterogeneous and rare group of solid tumors mesenchymal origin that can arise anywhere in the body. Although surgical resection is mainstay treatment for patients with localized disease, disease recurrence common 5-year overall survival poor (~ 65%). Both radiation therapy conventional chemotherapy used to reduce local distant recurrence. However, utility often limited by location (in case retroperitoneal sarcomas, instance) while systemic lines offer efficacy...
PURPOSE Undifferentiated pleomorphic sarcomas (UPSs) demonstrate therapy-induced hemosiderin deposition, granulation tissue formation, fibrosis, and calcification. We aimed to determine the treatment-assessment value of morphologic tumoral hemorrhage patterns first- high-order radiomic features extracted from contrast-enhanced susceptibility-weighted imaging (CE-SWI). MATERIALS AND METHODS This retrospective institutional review board–authorized study included 33 patients with extremity UPS...
Abstract BACKGROUND. Myxoid liposarcoma (MLPS), a disease especially of young adults with potential for local recurrence and metastasis, currently lacks solid prognostic factors therapeutic targets. The authors this report evaluated the natural history outcome patients MLPS commonly deregulated protein biomarkers. METHODS. Medical records were retrospectively reviewed who presented to authors' institution localized (n = 207) or metastatic 61) (1990 2010). A tissue microarray patient...
Abstract Purpose: MET signaling has been suggested a potential role in malignant peripheral nerve sheath tumors (MPNST). Here, function and blockade were preclinically assessed. Experimental Design: Expression levels of MET, its ligand hepatocyte growth factor (HGF), phosphorylated (pMET) examined clinically annotated MPNST tissue microarray (TMA) incorporating univariable multivariable statistical analyses. Human cells studied vitro vivo; Western blot (WB) ELISA used to evaluate HGF...
Histone deacetylase inhibitors (HDACi) show promise as cancer therapeutics; however, the full scope of their utility remains unknown. Here we report findings that strongly rationalize clinical evaluation HDACis in malignant peripheral nerve sheath tumors (MPNST), a class highly aggressive, therapeutically resistant, and commonly fatal malignancies occur sporadically or patients with inherited neurofibromatosis type-1 (NF1) syndrome. We evaluated effects chemical PCI-24781, suberoylanilide...