A5049286184- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Ethics in Clinical Research
- Fecal contamination and water quality
- Viral gastroenteritis research and epidemiology
- Microbial Community Ecology and Physiology
- Water Quality and Pollution Assessment
- Water Treatment and Disinfection
- Climate Change and Health Impacts
- Environmental DNA in Biodiversity Studies
- Antibiotic Use and Resistance
- Viral Infections and Immunology Research
- Genomics and Phylogenetic Studies
- Child Nutrition and Water Access
- Groundwater and Isotope Geochemistry
- Hepatitis Viruses Studies and Epidemiology
- Aquatic Ecosystems and Phytoplankton Dynamics
UK Centre for Ecology & Hydrology
2020-2025
Health First
2022
We investigated the seasonal prevalence of seven enteric viruses in groundwater-derived public water sources distributed across dominant aquifers England. Sampling targeted four periods hydrological cycle with typically varying microbial risks, as indicated using a decade Escherichia coli data. Viruses were concentrated onsite by filtration raw groundwater, and extracted nucleic acid (NA) was amplified qPCR or RT-qPCR. Seven out eight sources, all aquifers, 31% samples positive for viral NA....
Abstract The environment plays a critical role in the development, dissemination, and transmission of antimicrobial resistance (AMR). Pharmaceuticals personal care products (PPCPs) enter through direct application to anthropogenic pollution. Although there is growing body evidence defining minimal selective concentrations (MSCs) antibiotics play horizontal gene transfer (HGT), limited on non‐antibiotic PPCPs. Existing data show associations with development or effects bacterial growth rather...
Antimicrobial resistance (AMR) is a global health hazard. Although clinical and agricultural environments are well-established contributors to the evolution dissemination of AMR, research on wastewater treatment works (WwTWs) has highlighted their potential role as disseminators AMR in freshwater environments. Using metagenomic sequencing analysis, we investigated changes resistomes associated mobile genetic elements within untreated influents treated effluents five WwTWs, sediments...
The Ganga River (known internationally as the Ganges) is one of world's most prominent rivers, running from Himalayas to Bay Bengal and supporting livelihoods > 40 % India's 1.4 billion population. regionally globally important, agriculture industry, yet faces potentially detrimental water quality challenges arising runoff discharge increasing urbanization, industry agriculture. A ∼ 2700 km longitudinal survey nutrient microbial quality, including phytoplankton composition, was undertaken in...
Abstract Background Shotgun metagenomic sequencing is increasingly popular in taxonomic and resistome-profiling of polymicrobial samples due to its agnostic nature data versatility. However, caveats include high- cost, depth/sensitivity trade-offs, challenging bioinformatic deconvolution. Targeted PCR-based profiling optimises sensitivity cost-effectiveness, but can only identify prespecified targets may introduce amplification biases. Ultra-high multiplexed PCR a potential compromise. As no...
Abstract Recent evidence suggests that anthropogenic activity can increase the levels of antimicrobial resistance (AMR) in environment. Rivers and waterways are significant examples environmental settings have become repositories antibiotics antibiotic genes (ARGs). Our recent study quantified drug concentrations freshwater samples taken at a range sites located on Thames catchment; highest other drugs were recorded downstream waste water treatment plants (WWTPs). One specific antibiotic:...