A5057842727- Microbial Fuel Cells and Bioremediation
- Microbial Metabolic Engineering and Bioproduction
- 3D Printing in Biomedical Research
- Microbial Community Ecology and Physiology
- Algal biology and biofuel production
- Biomedical and Engineering Education
- Spaceflight effects on biology
- Transgenic Plants and Applications
- Plant tissue culture and regeneration
- Electrocatalysts for Energy Conversion
- CO2 Reduction Techniques and Catalysts
- Genomics and Phylogenetic Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Modular Robots and Swarm Intelligence
- Nanoparticles: synthesis and applications
- CRISPR and Genetic Engineering
- Technology Assessment and Management
- Advanced battery technologies research
- Photosynthetic Processes and Mechanisms
- Supercapacitor Materials and Fabrication
University of California, Berkeley
2020-2024
Biotechnology Institute
2017
University of Delaware
2017
A crewed mission to and from Mars may include an exciting array of enabling biotechnologies that leverage inherent mass, power, volume advantages over traditional abiotic approaches. In this perspective, we articulate the scientific engineering goals constraints, along with example systems, guide design a surface biomanufactory. Extending past arguments for exploiting stand-alone elements biology, argue integrated biomanufacturing plant replete modules microbial in situ resource utilization,...
Abstract Space bioprocess engineering (SBE) is an emerging multi-disciplinary field to design, realize, and manage biologically-driven technologies specifically with the goal of supporting life on long term space missions. SBE considers synthetic biology under extreme constraints conditions space. A coherent strategy for development this lacking. In Perspective, we describe need expanded mandate explore biotechnological needs future We then identify several key parameters—metrics,...
Electromicrobial production (EMP) systems can store renewable energy and CO2 in many-carbon molecules inaccessible to abiotic electrochemistry. Here, we develop a multiphysics model investigate the fundamental practical limits of EMP enabled by direct electron uptake. We also identify potential electroautotrophic organisms metabolic engineering strategies enable electroautotrophy lacking native capability. Systematic comparisons microbial respiration carbon fixation revealed that, under...
A crewed mission to and from Mars may include an exciting array of enabling biotechnologies that leverage inherent mass, power, volume advantages over traditional abiotic approaches. In this perspective, we articulate the scientific engineering goals constraints, along with example systems, guide design a surface biomanufactory. Extending past arguments for exploiting stand-alone elements biology, argue integrated biomanufacturing plant replete modules microbial \textit{in situ} resource...
Abstract Spirulina is the common name for edible, nonheterocystous, filamentous cyanobacterium Arthrospira platensis that grown industrially as a food supplement, animal feedstock, and pigment source. Although there are many applications engineering this organism, until recently no genetic tools or reproducible transformation methods have been published. While recent work showed production of diversity proteins in A. , including single‐domain antibodies oral delivery, remains need modular,...
Space missions have always assumed that the risk of spacecraft malfunction far outweighs human system failure. This assumption breaks down for longer duration exploration and exposes vulnerabilities in space medical system. agencies can no buy majority through crew member selection process emergency re-supply or evacuation. No mature solutions exist to close gap. With recent advances biotechnology, there is promise augmenting a pharmacy with biologically-based foundry on-demand manufacturing...
Abstract Microbial electrosynthesis (MES) systems can store renewable energy and CO 2 in many-carbon molecules inaccessible to abiotic electrochemistry. Here, we develop a multiphysics model investigate the fundamental practical limits of MES enabled by direct electron uptake identify organisms which this biotechnological -fixation strategy be realized. Systematic comparisons microbial respiration carbon fixation strategies revealed that, under aerobic conditions, rate is limited <6...
The green sulfur bacteria (Chlorobiaceae) are anaerobes that use electrons from reduced compounds (sulfide, S0, and thiosulfate) as electron donors for photoautotrophic growth. Chlorobaculum tepidum, the model system Chlorobiaceae, both produces consumes extracellular S0 globules depending on availability of sulfide in environment. These physiological changes imply significant gene regulation, which has been observed when is added to Cba. tepidum growing thiosulfate. However, underlying...
Reinvigorated public interest in human space exploration has led to the need address science and engineering challenges described by NASA's Space Technology Grand Challenges (STGCs) for expanding presence space. Here we define Bioprocess Engineering (SBE) as a multi-disciplinary approach design, realize, manage biologically-driven mission it relates addressing STGCs advancing technologies support nutritional, medical, incidental material requirements that will sustain astronauts against...
Abstract Spirulina is the common name for edible, non-heterocystous, filamentous cyanobacterium Arthrospira platensis that grown industrially as a food supplement, animal feedstock, and pigment source. Although there are many applications engineering this organism 1–3 , until recently no genetic tools or reproducible transformation methods have been published. While recent work showed production of diversity proteins in A. including single domain antibodies oral delivery, remains need...
Reinvigorated public interest in human space exploration has led to the need address science and engineering challenges described by NASA's Space Technology Grand Challenges (STGCs) for expanding presence space. Here we define Bioprocess Engineering (SBE) as a multi-disciplinary approach design, realize, manage biologically-driven mission it relates addressing STGCs advancing technologies support nutritional, medical, incidental material requirements that will sustain astronauts against...
Abstract The green sulfur bacteria ( Chlorobiaceae ) are anaerobes that use electrons from reduced compounds (sulfide, S(0), and thiosulfate) as electron donors for photoautotrophic growth. Chlorobaculum tepidum , the model system both produces consumes extracellular S(0) globules depending on availability of sulfide in environment. These physiological changes imply significant gene regulation, which has been observed when is added to Cba. growing thiosulfate. However, underlying mechanisms...
Abstract Electromicrobial production (EMP) processes based on CO 2 -fixing microbes that directly accept electrons from a cathode have received significant attention in the past decade. However, fundamental questions about performance limits and viability of this strategy remain unanswered. Here, we sought to determine what would be necessary for such system compete with alternative sustainable technologies H -mediated EMP traditional bioprocessing crop feedstocks. Using global warming...