A5076870160- Tissue Engineering and Regenerative Medicine
- Ion channel regulation and function
- Pluripotent Stem Cells Research
- Congenital heart defects research
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Electrospun Nanofibers in Biomedical Applications
- Nicotinic Acetylcholine Receptors Study
- Cardiac electrophysiology and arrhythmias
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Muscle Physiology and Disorders
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Cholinesterase and Neurodegenerative Diseases
- interferon and immune responses
- Cellular Mechanics and Interactions
- Photoreceptor and optogenetics research
- Lipid Membrane Structure and Behavior
- Chromatin Remodeling and Cancer
Institut des Biomolécules Max Mousseron
2015-2022
Centre National de la Recherche Scientifique
1999-2015
Université de Montpellier
2015
Centre de Recherche en Biologie cellulaire de Montpellier
1997-2013
Universidad de Navarra
2003
Universitat de València
2003
Institut de Génétique Humaine
2001
Harvard University
2000
Brigham and Women's Hospital
2000
Cardiomyocyte regeneration is limited in adult life. Thus, the identification of a putative source cardiomyocyte progenitors great interest to provide usable model vitro and new perspective regenerative therapy. As adipose tissues were recently demonstrated contain pluripotent stem cells, emergence phenotype from adipose-derived cells was investigated. We that rare beating with features could be identified after culture stroma without addition 5-azacytidine. The first by morphological...
In the adult, heart rate is driven by spontaneous and repetitive depolarizations of pacemaker cells to generate a firing action potentials propagating along conduction system spreading into ventricles. early embryo before E9.5, ionic channel responsible for depolarization not yet functional. Thus mechanisms that initiate rhythm during cardiogenesis are puzzling. absence functional channel, oscillatory nature inositol 1,4,5-trisphosphate (InsP3)-induced intracellular Ca2+ signaling could...
Objective: Migration and proliferation of arterial smooth muscle cells are critical responses during restenosis after balloon angioplasty. We investigated the changes in expression Ca2+ channels dystrophin, two determinants contraction, injury rat aortas. Methods: Proliferation migration aortic myocytes were triggered vivo by passage an inflated catheter aortas 12-week-old male Wistar rats. used whole-cell patch clamp technique to investigate Ba2+ currents (IBa) through single freshly...
Embryonic stem (ES) cells represent a source for cell-based regenerative therapies of heart failure. The pluripotency and the plasticity ES allow them to be committed cardiac lineage following treatment with growth factors transforming factor (TGF)-β superfamily. We describe protocol designed turn on expression cardiac-specific genes in undiffer entiated murine stimulated BMP2 and/or TGF-β. Cell commit ment results significant improvement spontaneous differentiation both vitro vivo.
The cytotoxic properties of an amphiphilic synthetic peptide are presented. Comparative analysis proliferating, differentiated and confluent H9C2 adherent cells L1210 in suspension shows a correlation between toxicity cell stage (proliferating cells). Electrophysiological measurements on Xenopus laevis oocytes bathed the also demonstrated induction cationic currents, which is voltage phosphate dependent. These results allow us to hypothesize that observed related membrane hyperpolarization...
Our group has been interested in the structure and function of voltage-gated Ca2+ channels since many years. We have tried to combine molecular cloning, site-directed mutagenesis, heterologous expression, electrophysiological recordings fluorescence imaging identify structures motions understand mechanisms that are responsible for several biophysical properties these channels. In this talk I will present you a brief overview work with special emphasis on voltage-dependent inactivation...