A5066042653- Italian Literature and Culture
- Glioma Diagnosis and Treatment
- Multi-Criteria Decision Making
- Data Management and Algorithms
- Linguistic Studies and Language Acquisition
- Time Series Analysis and Forecasting
- Cancer Cells and Metastasis
- Data Mining Algorithms and Applications
- Advanced Statistical Methods and Models
- Advanced Clustering Algorithms Research
- Sensory Analysis and Statistical Methods
- Bayesian Modeling and Causal Inference
- Game Theory and Voting Systems
- Italian Fascism and Post-war Society
- Neural Networks and Applications
- Rough Sets and Fuzzy Logic
- Classical Antiquity Studies
- Cancer Diagnosis and Treatment
- Ancient Mediterranean Archaeology and History
- Diverse academic and cultural studies
- Anomaly Detection Techniques and Applications
- Traffic and Road Safety
- Data Visualization and Analytics
- Semiconductor Lasers and Optical Devices
- Myasthenia Gravis and Thymoma
University of Naples Federico II
2014-2024
I.R.C.C.S. Oasi Maria SS
2024
Candiolo Cancer Institute
2016-2023
University of Florence
2023
Federico II University Hospital
2023
University of Turin
2012-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2021
University of Campania "Luigi Vanvitelli"
2012-2019
Centre for Studies in Economics and Finance
2018
Fondazione Piemontese per la Ricerca sul Cancro Onlus
2016
The existence of treatment-resistant cancer stem cells contributes to the aggressive phenotype glioblastoma. However, molecular alterations that drive cell proliferation in these tumors remain unknown. In this study, we found expression MET oncogene was associated with neurospheres expressing gene signature mesenchymal and proneural subtypes Met almost absent from classical subtype mutually exclusive amplification EGF receptor (EGFR) gene. Met-positive Met-negative displayed distinct growth...
The aims of this survey were to ascertain pregnant women's level knowledge and acceptability on the vaccinations identify their associations with several characteristics. A cross-sectional study was performed from December 2017 through March 2018 in geographic area Naples, Italy. used two stages cluster sampling method for selection recruitment participants. Data collected face-to-face interviews women present at Obstetrics outpatient clinic selected hospitals. total 358 respondents agreed...
Exploratory analysis was made of data from pedestrian crashes to detect interdependence and dissimilarities between crash patterns provide insight for the development safety improvement strategies focused on pedestrians. Data-mining techniques, such as classification trees association rules, were used related 56,014 that occurred in Italy 2006 2008. Crash severity response variable most sensitive patterns. The influential road type, age, lighting conditions, vehicle interactions these...
Glioblastoma (GBM) contains stem-like cells (GSCs) known to be resistant ionizing radiation and thus responsible for therapeutic failure rapidly lethal tumor recurrence. It is that GSC radioresistance relies on efficient activation of the DNA damage response, but mechanisms linking this response with stem status are still unclear. Here, we show MET receptor kinase, a functional marker GSCs, specifically expressed in subset radioresistant GSCs overexpressed human GBM recurring after...
Glioblastoma (GBM) is a lethal tumor that displays remarkable genetic heterogeneity. It also known GBM contains cell hierarchy driven by stem-like cells (GSCs), responsible for generation, therapeutic resistance, and relapse. An important still open issue whether phylogenetically related GSCs can be found in matched primary recurrent GBMs, reflect evolution under pressure. To address this, we analyzed the mutational profile of isolated from either human GBMs (primary GSCs) or their tumors...
Abstract Cancers of unknown primary (CUPs), featuring metastatic dissemination in the absence a tumor, are biological enigma and fatal disease. We propose that CUPs distinct, yet unrecognized, pathological entity originating from stem-like cells endowed with peculiar shared properties. These can be isolated vitro (agnospheres) propagated vivo by serial transplantation, displaying high tumorigenicity. After subcutaneous engraftment, agnospheres recapitulate CUP phenotype, spontaneously...
When data are affected by multicollinearity in the linear regression framework, then concurvity will be present fitting a generalized additive model (GAM). The term describes nonlinear dependencies among predictor variables. As collinearity results inflated variance of estimated coefficients model, result presence leads to instability GAMs. Even if backfitting algorithm always converge solution, case final solution procedure GAM is influenced starting functions. While exact highly unlikely,...
ERBB3 overexpression due to miR-205 inactivation confers sensitivity FGF, metabolic activation,
e20140 Background: Thymic epithelial tumors (TETs) are rare neoplasms often associated with paraneoplastic syndromes, which manifest as either autoimmune diseases (AD) or immunodeficiency-related conditions, such Good Syndrome (GS). Prognostic factors for TETs primarily defined by the TNM staging system and Masaoka-Koga classification. However, to date, no studies have explored relationship between immunophenotype, cytokine chemokine levels, clinical outcomes in patients (pts) TETs. This...