Gregorio Maria Bergonzi
A5005270663- Otitis Media and Relapsing Polychondritis
- Dialysis and Renal Disease Management
- Vascular Anomalies and Treatments
- Platelet Disorders and Treatments
- Blood properties and coagulation
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Mast cells and histamine
- Blood groups and transfusion
- Chronic Myeloid Leukemia Treatments
- Abdominal Surgery and Complications
- Monoclonal and Polyclonal Antibodies Research
- Congenital Ear and Nasal Anomalies
- Muscle and Compartmental Disorders
- Biochemical and Molecular Research
- Advanced biosensing and bioanalysis techniques
- Connective tissue disorders research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Ophthalmology and Eye Disorders
- Multiple Myeloma Research and Treatments
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2024-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2024-2025
Vita-Salute San Raffaele University
2024-2025
IRCCS Ospedale San Raffaele
2023
Ospedaliera di Piacenza
1990-2015
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2015
VEXAS syndrome is an acquired autoinflammatory disease characterized in most cases by cytopenias and macrocytic anemia. Dyshematopoiesis a frequent finding chronic inflammatory conditions therefore, are not easily classified patients. Here we report series of 7 patients affected associated cytopenias, treated at our center. The use NGS, together with morphological assays, integrated the WHO 2022 criteria, allowed to identify three subsets cytopenias: ICUS (idiopathic cytopenia uncertain...
Clonal dominance characterizes hematopoiesis during aging and increases susceptibility to blood cancers common nonmalignant disorders. VEXAS syndrome is a recently discovered, adult-onset, autoinflammatory disease burdened by high mortality rate caused dominant hematopoietic clones bearing somatic mutations in the UBA1 gene. However, pathogenic mechanisms driving clonal are unknown. Moreover, lack of models hampers development disease-modifying therapies. In present study, we performed...
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Recently the possible storage of dextran-related material in patients undergoing regular haemodialysis has been suggested. We examined biopsy and autopsy specimens 32 treated with for 61 +/- 34 months. All received dextran-40 as a plasma expander because hypotension during haemodialysis. The same study was carried out control group 11 haemodialysed who were given other expanders. In larger doses (0.38 g/kg body weight per week) we found particles cytoplasm macrophages various organs, which...
Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) is a haemato-inflammatory syndrome genetically defined by mutations in the X-linked UBA1 gene, typically Val/Thr/Leu substitutions at Met41 hotspot. Clinical manifestations are heterogeneous and refractory to most haemato-rheumatological treatments. To date, no guidelines exist for management of VEXAS, scarce evidence on methodology clinical significance longitudinal clonal burden evaluation upon therapy. Here, we validated...
Increasing the survival of patients on CAPD is related to long-term reliability peritoneal access. Six silicone Tenckhoff catheters (with strip or diffuse barium sulphate inclusion) removed after 39-69 months because appearance external segment fissures, were analysed by scanning electron microscopy (SEM) and infra-red spectroscopy with attenuated total refractance (ATR). The extracorporeal portion showed (by ATR) a more prominent oxidation peak than internal surface; SEM marks cracks...
Allogeneic HSCT (aHSCT) is the only curative treatment, reserved for IPSS-R higher risk (HR, > 3.5) MDS. Molecular data have been integrated within recently validated IPSS-Mol score system, in order to better predict clinical outcome. However, not still used guide decisions. We aim investigate significance a cohort of MDS patients transplanted at our center. retrospectively analyzed 74 undergoing aHSCT between 2010-2022 center according score. All received treosulfan-based conditioning...
Topic: 10. Myelodysplastic syndromes - Clinical Background: Chronic Myelomonocytic Leukemia (CMML) is a rare hematologic malignancy at risk to progress secondary acute myeloid leukemia (AML). Few patients are reported in the literature have both CMML and plasma cell disease, mostly Multiple Myeloma; furthermore, no data about concomitant detection significance of monoclonal gammopathy undefined (MGUS) available. Aims: We retrospectively conducted an analysis affected by CMML, prospectively...