A5070985188- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological diseases and metabolism
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Bioinformatics and Genomic Networks
- Diet and metabolism studies
- Dementia and Cognitive Impairment Research
- Tryptophan and brain disorders
- Genetics, Aging, and Longevity in Model Organisms
- Nursing Diagnosis and Documentation
- Stress Responses and Cortisol
- Calcium signaling and nucleotide metabolism
- Health, Environment, Cognitive Aging
- Amino Acid Enzymes and Metabolism
- Pancreatic function and diabetes
- S100 Proteins and Annexins
- Nanoparticles: synthesis and applications
- Natural Antidiabetic Agents Studies
- Heavy Metal Exposure and Toxicity
- Protease and Inhibitor Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Long-Term Effects of COVID-19
- Pluripotent Stem Cells Research
Pontificia Universidad Católica Madre y Maestra
2019-2025
Universidad de Antioquia
2023
Universidad de Cádiz
2012-2013
Although extensive evidence supports the role of β-amyloid (Aβ) in Alzheimer disease (AD), neurotoxic mechanisms underlying AD pathogenesis are not understood. On other hand, neuronal loss is pathologic feature that best correlates with cognitive impairment. We hypothesized cholinergic neurodegeneration may lead to Aβ deposition and tested this by inducing selective lesions APPswe/PS1dE9 mice murine p75 saporin (mu p75-SAP). Intracerebroventricular removed approximately 50% innervation...
Type 2 diabetes (T2D) mellitus and Alzheimer's disease (AD) are two prevalent diseases with comparable pathophysiological features genetic predisposition. Patients AD more susceptible to develop T2D. However, the molecular mechanism linking T2D remains elusive. In this study, we have generated a new mouse model test hypothesis that would prompt onset of in mice. To our hypothesis, crossed Alzheimer APPswe/PS1dE9 (APP/PS1) transgenic mice partially deficient leptin signaling (db/+). Body...
The α-synucleinopathies constitute a subset of neurodegenerative disorders, which Parkinson's disease (PD) is the most common worldwide, characterized by accumulation misfolded α-synuclein in cytoplasm neurons, spreads prion-like manner to anatomically interconnected brain areas. However, it not clear how α-synucleinopathy triggers neurodegeneration. We recently developed rat model through single intranigral administration neurotoxic β-sitosterol β-D-glucoside (BSSG), produces...
Alzheimer’s disease (AD) is a neurodegenerative disease, characterized histopathologically by intra-neuronal tau-related lesions and the accumulation of amyloid β-peptide (Aβ) in brain parenchyma around cerebral blood vessels. According to vascular hypothesis AD, an alteration neurovascular unit (NVU) could lead Aβ promote neuronal dysfunction, accelerating neurodegeneration dementia. To date, effects insoluble deposits on NVU blood–brain barrier (BBB) are unknown. In this study, we analyze...
Worldwide, around 50 million people have dementia. Alzheimer's disease (AD) is the most common type of dementia and one major causes disability dependency among elderly worldwide. Clinically, AD characterized by impaired memory accompanied other deficiencies in cognitive domain. Neuritic plaques (NPs) neurofibrillary tangles (NFTs) are histopathological lesions that define brains with AD. NFTs consist abundant intracellular paired helical filaments (PHFs) whose main constituent tau protein....
Background: Alzheimer’s disease (AD) and progressive supranuclear palsy (PSP) are examples of neurodegenerative diseases, characterized by abnormal tau inclusions, that called tauopathies. AD is highly insoluble paired helical filaments (PHFs) composed with post-translational modifications. PSP a pathological clinical heterogeneity. There six isoforms expressed in the adult human brain, repeated microtubule-binding domains three (3R) or four (4R) repeats. In AD, 4R:3R ratio 1:1. PSP, 4R...
Abstract Alzheimer's disease is characterized by progressive memory loss and deterioration of cognitive functions. The presence neurofibrillary tangles in the hippocampal areas (perforant pathway) correlates with impairment. Pathological processing tau protein post-translational changes such as hyperphosphorylation truncation, which favour conformational within tau. These can be regional (dependent on phosphorylation) or structural (depending truncation). Through immunohistochemical...
Neurofibrillary tangles (NFTs) and amyloid plaques are the neuropathological hallmarks in brains with Alzheimer's disease (AD). Post-translational modifications of tau, such as phosphorylation truncation, have been proposed initiators assembly abnormal paired helical filaments that constitute NFTs. Neurons NFTs sites matrix metalloproteinases (MMPs).The aim this study was to analyze relationship MMP-9 tau protein brain samples AD.This performed on tissue from patients early, moderate, late...
Alzheimer's disease (AD) is the most common neurodegenerative worldwide. Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and aggregates of amyloid β peptide (Aβ) both in brain parenchyma as neuritic plaques, around blood vessels cerebral angiopathy. According to vascular hypothesis AD, risk factors can result dysregulation neurovascular unit (NVU) hypoxia. Hypoxia may reduce Aβ clearance from increase its production, leading parenchymal accumulation Aβ....
We recently developed the National Dementia Biobank in México (BioBanco Nacional de Demencias, BND) as a unit for diagnosis, research, and tissue transfer research purposes. BND is associated with Facultad Estudios Superiores Cuautitlán, Universidad Autónoma Mexico (UNAM), Mexico. The donation of fluids, brain, other organs deceased donors crucial understanding underlying mechanisms neurodegenerative diseases development successful treatment. Our laboratory focuses on 1) analysis molecular...
We present here the first description of tau in human dental pulp stem cells (DPSCs) evidenced by RT-PCR data on expression gene MAPT and immunocytochemical detection epitopes 12 anti-tau antibodies. The specificity eight these antibodies was confirmed their affinity to neurofibrillary tangles (NFTs) Alzheimer's disease (AD) postmortem brain samples. therefore used DPSCs AD samples as a test system for determining probability involvement mechanisms converting into NFT AD. Three...
Estimate the acceptability and adoption by health care workers of clinical practice guidelines treatment protocols for women with preeclampsia/eclampsia identify facilitating factors barriers to their implementation.A qualitative study was conducted, using semi-structured interviews focus groups in five maternity hospitals. Interviews were compiled analysis, facilitators characterized.Seventy professionals (52 female 18 male) participated, representing different levels system. The majority...
Introduction Proteolytic processing of amyloid protein precursor by β-site secretase enzyme (BACE1) is dependent on the cellular lipid composition and affected endomembrane trafficking in dementia Alzheimer's disease (AD). Stearoyl-CoA desaturase 1 (SCD1) responsible for synthesis fatty acid monounsaturation (MUFAs), whose accumulation strongly associated with cognitive dysfunction. Methods In this study, we analyzed relationship between BACE1 SCD1 vivo vitro neurodegenerative models their...
Background: Transmissible spongiform encephalopathies (TSEs) are rare neurodegenerative disorders that affect animals and humans. Bovine encephalopathy (BSE) in cattle, Creutzfeld-Jakob Disease (CJD) humans belong to this group. The causative agent of TSEs is called “prion”, which corresponds a pathological form (PrPSc) normal cellular protein (PrPC) expressed nerve cells. PrPSc resistant degradation can induce abnormal folding PrPC, characterized by extensive spongiosis gliosis the presence...