A5022932457- Pancreatic function and diabetes
- Angiogenesis and VEGF in Cancer
- Alzheimer's disease research and treatments
- Peripheral Artery Disease Management
- Mesenchymal stem cell research
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Neurological Disease Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cholesterol and Lipid Metabolism
- Pluripotent Stem Cells Research
- Protein Kinase Regulation and GTPase Signaling
- Diabetic Foot Ulcer Assessment and Management
- Diabetes Treatment and Management
- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Regulation of Appetite and Obesity
- Protease and Inhibitor Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Antidiabetic Agents Studies
- Congenital heart defects research
- Lymphatic System and Diseases
- Platelet Disorders and Treatments
- Neurological Disorders and Treatments
Biomedical Research and Innovation Institute of Cadiz
2020-2024
Universidad de Cádiz
2020-2024
Instituto de Investigación Biomédica de A Coruña
2020-2023
University of Michigan
2015-2017
Michigan Medicine
2016
Hospital Universitario Puerta del Mar
2011-2015
Universidad de Valladolid
2014
Abstract Deregulation of mTOR complex 1 (mTORC1) signalling increases the risk for metabolic diseases, including type 2 diabetes. Here we show that β-cell-specific loss mTORC1 causes diabetes and β-cell failure due to defects in proliferation, autophagy, apoptosis insulin secretion by using mice with conditional ( βraKO) inducible MIP-βraKO f/f ) raptor deletion. Through genetic reconstitution downstream targets, identify mTORC1/S6K pathway as mechanism which regulates apoptosis, size...
Type 2 diabetes (T2D) is an important risk factor to suffer dementia, including Alzheimer's disease (AD), and some neuropathological features observed in dementia could be mediated by T2D metabolic alterations. Since brain atrophy impaired neurogenesis have been both AD we analyzed central nervous system (CNS) morphological alterations the db/db mice (leptin receptor KO mice), as a model of long-term insulin resistance T2D, C57Bl6 fed with high fat diet (HFD), induced prediabetes. Db/db...
Type 2 diabetes (T2D) mellitus and Alzheimer's disease (AD) are two prevalent diseases with comparable pathophysiological features genetic predisposition. Patients AD more susceptible to develop T2D. However, the molecular mechanism linking T2D remains elusive. In this study, we have generated a new mouse model test hypothesis that would prompt onset of in mice. To our hypothesis, crossed Alzheimer APPswe/PS1dE9 (APP/PS1) transgenic mice partially deficient leptin signaling (db/+). Body...
Aging continues to be the main cause of development Alzheimer’s, although it has been described that certain chronic inflammatory pathologies can negatively influence progress dementia, including obesity and hyperlipidemia. In this sense, previous studies have shown a relationship between low-density lipoprotein receptor (LDLR) amyloid-beta (Aβ) binding activity, one neuropathological features Alzheimer’s disease (AD). LDLR is involved in several processes, lipid transport, regulation...
In atherosclerosis, circulating angiogenic cells (CAC), also known as early endothelial progenitor (eEPC), are thought to participate mainly in a paracrine fashion by promoting the recruitment of other cell populations such late EPC, or colony-forming (ECFC), injured areas. There, ECFC replace damaged endothelium, neovascularization. However, despite their regenerative role, number and function EPC severely affected under pathological conditions, being essential further understand how these...
Abstract Background Critical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by blockade arteries supplying blood to lower extremities, significantly diminishing oxygen and nutrient supply. CLI patients usually undergo amputation fingers, feet, or with a high risk mortality due associated comorbidities. Circulating angiogenic cells (CACs), also known as early endothelial progenitor cells, constitute promising candidates for...
The mammalian target of rapamycin complex 1 (mTORC1) regulates several biological processes, although the key downstream mechanisms responsible for these effects are poorly defined. Using mice with deletion eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2), we determine that this is a major regulator glucose homeostasis and β-cell mass, proliferation, survival by increasing insulin receptor substrate (IRS2) levels identify novel feedback mechanism which mTORC1 signaling...
There is an urgency to find new treatments for the devastating epidemic of diabetes. Pancreatic β-cells viability and function are impaired in two most common forms diabetes, type 1 2. Regeneration pancreatic has been proposed as a potential therapy In preliminary study, we screened collection marine products β-cell proliferation. One unique compound (epoxypukalide) showed capability induce replication cell line INS1 832/13 primary rat cultures. Epoxypukalide was used study proliferation by...
Critical limb-threatening ischemia (CLTI) constitutes the most severe manifestation of peripheral artery disease, usually induced by atherosclerosis. CLTI patients suffer from high risk amputation lower extremities and elevated mortality rates, while they have low options for surgical revascularization due to associated comorbidities. Alternatively, cell-based therapeutic strategies represent an effective safe approach promote revascularization. However, variability seen in several factors...
Activation of pancreatic β-cell proliferation has been proposed as an approach to replace reduced functional mass in diabetes. Quiescent fibroblasts exit from G0 (quiescence) G1 through pRb phosphorylation mediated by cyclin C/cdk3 complexes. Overexpression D1, D2, D3, or E induces proliferation. We hypothesized that C overexpression would induce exit, thus being a potential therapeutic target recover mass. used isolated rat and human islets transduced with adenovirus expressing C. measured...
Background: Bone Marrow Mononuclear Cells (BM-MNC) constitute a promising alternative for the treatment of Chronic Limb-Threatening ischemia (CLTI), disease characterized by extensive blockade peripheral arteries, clinically presenting as excruciating pain at rest and ischemic ulcers which may lead to gangrene amputation. BM-MNC implantation has shown be efficient in promoting angiogenesis ameliorating symptoms CLTI patients. However, variability seen between clinical trials makes necessary...
Critical limb ischemia (CLI), the most severe form of peripheral artery disease, results from blockade vessels, usually correlated to atherosclerosis. Currently, endovascular and surgical revascularization strategies cannot be applied all patients due related comorbidities, even so, require re-intervention or amputation within a year. Circulating angiogenic cells (CACs) constitute good alternative as CLI cell therapy their vascular regenerative potential, although mechanisms action these...
There is an urgency to find new treatments for the devastating epidemic of diabetes.Pancreatic b-cells viability and function are impaired in two most common forms diabetes, type 1 2. Regeneration pancreatic has been proposed as a potential therapy diabetes.In preliminary study, we screened collection marine products b-cell proliferation.One unique compound (epoxypukalide) showed capability induce replication cell line INS1 832/ 13 primary rat cultures.Epoxypukalide was used study...