A5055225274- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Systemic Sclerosis and Related Diseases
- Bladder and Urothelial Cancer Treatments
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Inflammatory Bowel Disease
- CAR-T cell therapy research
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Surgical Treatments
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Viral-associated cancers and disorders
- Cutaneous Melanoma Detection and Management
- vaccines and immunoinformatics approaches
- Prostate Cancer Treatment and Research
- Neonatal Respiratory Health Research
- Tissue Engineering and Regenerative Medicine
- Urinary and Genital Oncology Studies
- Nanowire Synthesis and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Fibroblast Growth Factor Research
Brigham and Women's Hospital
2018-2024
Harvard University
2019-2023
City Of Hope National Medical Center
2023
Dana-Farber Cancer Institute
2022
CS Diagnostics
2017
University of Verona
2014-2017
Abstract Sarcomatoid and rhabdoid (S/R) renal cell carcinoma (RCC) are highly aggressive tumors with limited molecular clinical characterization. Emerging evidence suggests immune checkpoint inhibitors (ICI) particularly effective for these tumors, although the biological basis this property is largely unknown. Here, we evaluate multiple trial real-world cohorts of S/R RCC to characterize their features, outcomes, immunologic characteristics. We find that harbor distinctive features may...
One of the major hurdles that has hindered success chimeric antigen receptor (CAR) T cell therapies against solid tumors is on-target off-tumor (OTOT) toxicity due to sharing same epitopes on normal tissues. To elevate safety profile CAR-T cells, an affinity/avidity fine-tuned CAR was designed enabling activation only in presence a highly expressed tumor associated (TAA) but not when recognizing at physiological level healthy cells. Using direct stochastic optical reconstruction microscopy...
Abstract Purpose: We sought to validate levels of CD8+ tumor-infiltrating cells (TIC) expressing PD-1 but not TIM-3 and LAG-3 (IF biomarker; Pignon colleagues, 2019) investigate human endogenous retroviruses (hERV) as predictors response anti–PD-1 in a randomized trial nivolumab (nivo) versus everolimus (evero) patients with metastatic clear cell renal carcinoma (mccRCC; CheckMate-025). Experimental Design: Tumor tissues (nivo: n = 116, evero: 107) were analyzed by multiparametric...
Programmed death-ligand 1 (PD-L1) status by IHC is prognostic in metastatic renal cell carcinoma (mRCC), and its role as a potential predictive biomarker under investigation. Using tumor tissue from the METEOR (NCT01865747) CABOSUN (NCT01835158) clinical trials, we explored whether PD-L1 expression extent of immune infiltrate can serve and/or biomarkers for cabozantinib other targeted agents.IHC double staining CD45/CD163 (immune markers) was performed on (n = 306) 110) trials. Immune...
Renal cell carcinoma (RCC) of variant histology comprises approximately 20% kidney cancer diagnoses, yet the optimal therapy for these patients and factors that impact immunotherapy response remain largely unknown. To better understand determinants in this population, we characterized blood- tissue-based immune markers with RCC, or any RCC sarcomatoid differentiation, enrolled a phase II clinical trial atezolizumab bevacizumab. Baseline circulating (plasma) inflammatory cytokines were highly...
The lung alveoli slowly self-renew pneumocytes, but their facultative regeneration capacity is rapidly efficient after an injury, so fibrosis infrequently occurs. We recently observed Keratin 14 (KRT14) expression during diffuse alveolar damage (DAD), not in controls. wonder if KRT14 may be a marker of pneumocyte transition from quiescence to regeneration. Quantitative PCR and Western blot analyses highlighted the presence (mRNA protein) only human samples with DAD or interstitial disease...
The 2016 World Health Organization Renal Tumor Classification defines renal oncocytoma (RO) as a benign epithelial tumor; however, malignant histopathologic features have been documented. Rare cases with metastases reported. We describe the case of 62-year-old woman who was referred to Urology Clinic for routine work-up. Magnetic resonance imaging and computerized tomography showed 7-cm mass in middle lower portions left kidney 2 suspected liver metastases. patient underwent surgery....
5023 Background: We previously showed that levels of CD8+ tumor infiltrating cells (TIC) expressing PD-1 but not TIM-3 and LAG-3 (CD8 + PD1 TIM3 − LAG3 ) were associated with response to nivolumab (nivo) in pretreated mccRCC pts (Pignon et al, 2019). Here, we sought validate these findings a randomized Phase III trial nivo versus everolimus (evero) (CM-025) explore the association biomarker transcriptomic profiles. Methods: Tumor tissues from CM-025 analyzed (nivo arm: n = 116, evero 107)....
Acute Respiratory Distress Syndrome (ARDS) is a type of acute lung injury characterized on histology by pattern Diffuse Alveolar Damage(DAD). Since patients who survive their critical illness generally recover normal respiratory function, ARDS regarded as remarkable example in vivo alveolar regeneration and mice with chemical or viral-induced represent useful experimental model for studying these processes. Recent studies opened new insights into the mechanisms regeneration, partly...
Abstract Sarcomatoid and rhabdoid (S/R) renal cell carcinoma (RCC) are highly aggressive tumors with limited molecular clinical characterization. Emerging evidence suggests immune checkpoint inhibitors (ICI) particularly effective for these 1–3 , although the biological basis this property is largely unknown. Here, we evaluate multiple trial real-world cohorts of S/R RCC to characterize their features, outcomes, immunologic characteristics. We find that harbor distinctive features may...
Abstract Clear cell renal carcinoma (ccRCC) is the major type of RCC and among 10 most common cancers in both men women. ccRCC characterized by loss chromosome 3p, where von-Hippel-Lindau (VHL) gene found. Its product, pVHL suppresses hypoxia inducible factor (HIF) transcription factors deletion VHL leads to HIF hyperactivation, upregulating expression many downstream genes involved angiogenesis, metabolism, cell-cycle regulation. Two products, carbonic anhydrase IX (CAIX) CD70 which we are...
<div>AbstractPurpose:<p>Patients with advanced renal cell carcinoma sarcomatoid features (sRCC) have poor prognoses and suboptimal outcomes targeted therapy. This <i>post hoc</i> analysis of the phase III CheckMate 214 trial analyzed efficacy nivolumab plus ipilimumab (NIVO+IPI) versus sunitinib in patients sRCC.</p>Patients Methods:<p>Patients sRCC were identified via independent central pathology review archival tumor tissue or histologic classification...
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<p>Supplementary table 3</p>