A5022070811- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- melanin and skin pigmentation
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- RNA regulation and disease
- Retinoids in leukemia and cellular processes
- Music Therapy and Health
- Innovative Teaching and Learning Methods
- CRISPR and Genetic Engineering
- Photoreceptor and optogenetics research
- Connexins and lens biology
- Cellular transport and secretion
- Mitochondrial Function and Pathology
- Genetic Syndromes and Imprinting
- Cancer Risks and Factors
- Photochromic and Fluorescence Chemistry
- Distributed and Parallel Computing Systems
- Scientific Computing and Data Management
- Epigenetics and DNA Methylation
- Ocular Disorders and Treatments
- Online and Blended Learning
- RNA Interference and Gene Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Brunel University of London
2015-2025
MedStar Georgetown University Hospital
2025
Georgetown University
2025
MedStar Washington Hospital Center
2025
Exeter Primary Care
2009
Aminex Therapeutics (United States)
2008
Japan External Trade Organization
2007
University at Albany, State University of New York
1996-2006
University College London
1998-2004
St. James's Hospital
2002
Breast cancer (BC) is one of the most common cancers among women worldwide, representing majority new cases and cancer-related deaths according to global statistics, making it a significant public health problem in today’s society. The early diagnosis BC can improve prognosis chance survival significantly, as promote timely clinical treatment patients. Further accurate classification benign tumours prevent patients undergoing unnecessary treatments. Thus, correct into malignant or groups...
We report a mutation (Y99C) in guanylate cyclase activator 1A (GUCA1A), the gene for activating protein (GCAP1), family with autosomal dominant cone dystrophy. Linkage analysis excluded all known and cone-rod dystrophy loci, except chromosome 6p21.1 region. This is to contain RDS gene, which associated Screening of by heteroduplex direct sequencing failed demonstrate sequence changes coding region this gene. The GCAP1, calcium binding highly expressed photoreceptor outer segments, also...
The dominant cone-rod dystrophy gene CORD6 has previously been mapped to within an 8 cM interval on chromosome 17p12-p13. retinal-specific guanylate cyclase (RETGC-1), which maps this genetic and was implicated in Leber's congenital amaurosis, screened for mutations family a panel of small families individuals with various cone phenotypes. A missense mutation (E837D) identified affected members the family, as well second (R838C) three other dystrophy. RETGC-1 is only fourth be first report gene.
Abstract Orexins are neuropeptides that regulate the sleep-wake cycle and feeding behaviour. QRFP is a newly discovered neuropeptide which exerts similar orexigenic activity, thus playing an important role in energy homeostasis regulation of appetite. The exact expression signalling characteristics physiological actions its receptor GPR103 poorly understood. Alzheimer’s disease (AD) patients experience increased nocturnal excessive daytime sleepiness weight loss. We hypothesised therefore...
<h3>Objectives</h3> To describe the phenotype of Leber congenital amaurosis (LCA) in 26probands with mutations aryl hydrocarbon receptor interacting protein-like1 protein (<i>AIPL1</i>) and compare it phenotypesof other LCA-related genes. electroretinogram (ERG) heterozygotecarriers. <h3>Methods</h3> Patients with<i>AIPL1</i>-related LCA were identifiedin a cohort 303 patients by polymerase chain reaction single-strandconfirmational polymorphism mutation screening and/or direct sequencing....
Laboratory classes are commonplace and essential in biology departments but can sometimes be cumbersome, unreliable, a drain on time resources. As university intakes increase, pressure budgets staff often lead to reduction practical class provision. Frequently, the ability use laboratory equipment, mix solutions, manipulate test animals learning outcomes, “wet” thus appropriate. In others, however, interpretation manipulation of data primary here, computer-based simulations provide cheaper,...
Background: Metabolic syndrome (MetS) is a that comprises central obesity, increased serum triglyceride (TG) levels, decreased HDL cholesterol (HDL) raised blood pressure (BP), and impaired glucose regulation, including prediabetic diabetic glycaemic levels. Recently, the association with endometrial cancer (EC) has been described but it unclear if risk associated MetS higher than individual effect of obesity alone. This study investigates between components differing definitions on EC...
Paraneoplastic Limbic Encephalitis (PLE) is a neurocognitive condition caused by an immune response to neuronal proteins linked malignancy, such as testicular cancer. We report 25-year-old male with cognitive and personality changes. His initial MRI showed vasogenic edema. A subsequent CT scan revealed bilateral hydroceles, follow-up scrotal US uncovered right mass, leading radical orchiectomy that confirmed Sertoli cell tumor. Following immunomodulating therapy, the patient's symptoms...