A5067291667- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Pediatric health and respiratory diseases
- RNA and protein synthesis mechanisms
- Trypanosoma species research and implications
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Toxin Mechanisms and Immunotoxins
- Immune Cell Function and Interaction
- Skin and Cellular Biology Research
- Mycobacterium research and diagnosis
- Nail Diseases and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sinusitis and nasal conditions
- Infectious Diseases and Mycology
- Research on Leishmaniasis Studies
Universidad de Salamanca
2024
Instituto de Investigación Biomédica de Salamanca
2021-2024
Centre for Biomedical Network Research on Rare Diseases
2024
Centro de Investigación en Red en Enfermedades Cardiovasculares
2024
Instituto de Salud Carlos III
2024
Instituto de Investigación Biosanitaria de Granada
2023
Complejo Hospitalario de Salamanca
2023
Institut de Biologie Moléculaire et Cellulaire
2003
Simón Bolívar University
2003
Centre National de la Recherche Scientifique
2003
Salivarian trypanosomes use antigenic variation of their variant-specific surface glycoprotein (VSG) coat as a defense against the host immune system. Although about 1000 VSG and pseudo-VSG genes are scattered throughout trypanosome genome, each expresses only one VSG, while rest transcriptionally silent. A 64-kDa glycosylated cross-reacting antigen between Trypanosoma evansi vivax (p64), which was purified from TEVA1 T. Venezuelan isolate, proven here to represent soluble form VSG....
Background: Precision medicine is a promising strategy to identify biomarkers, stratify asthmatic patients according different endotypes, and match them with the appropriate therapy. This proof-of-concept study aimed investigate whether gene expression in peripheral blood could provide valuable noninvasive approach for molecular phenotyping of asthma. Methods: We performed whole-transcriptome RNA sequencing on 30 non-atopic non-asthmatic controls patients. A quantitative PCR (qPCR)...
Introduction Type 2 (T2) asthma is often associated with chronic rhinosinusitis nasal polyposis (CRSwNP). Additionally, nonsteroidal anti-inflammatory drug (NSAID) intolerance leads to NSAID-exacerbated respiratory disease (N-ERD). Previous transcriptomic data in non-CRSwNP T2 patients showed differentially expressed genes. We focused on ALOX15 , CLC CYSLTR2 HRH4 and SMPD3 investigate their role asthma. Methods The study included 100 healthy controls 103 patients, divided into (n=54), CRSwNP...
Allergic asthma is the most common type of asthma. It characterized by TH2 cell-driven inflammation in which interleukin-13 (IL-13) plays a pivotal role. Cytoplasmic RNAs (Y-RNAs), variety non-coding that are dysregulated many cancer types, also differentially expressed patients with allergic Their function development disease still unknown. We investigated potential role RNY3 RNA (hY3) cell inflammatory response using Jurkat line as model. hY3 expression levels were modulated to mimic...