A5009985775- Aquaculture disease management and microbiota
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Bacteriophages and microbial interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmaceutical and Antibiotic Environmental Impacts
- Atherosclerosis and Cardiovascular Diseases
- Probiotics and Fermented Foods
- Genomics and Phylogenetic Studies
- Aquaculture Nutrition and Growth
- Animal Nutrition and Physiology
- Identification and Quantification in Food
East China Normal University
2025
Guangzhou University
2022-2024
Probiotics have attracted considerable attention as potential antibiotic substitutes in aquaculture. However, their functional genomic characterisation remains incomplete. Therefore, this study aimed to evaluate the probiotic characteristics of Bacillus cereus G1-11 isolated from gut hybrid grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂) by integrating genomics and phenotypic characteristics. Genome mining revealed gene clusters that are responsible for acid bile tolerance well host...
Fish-related antibiotic resistance genes (ARGs) have attracted attention for their potentially harmful effects on food safety and human health through the chain transfer. However, potential factors affecting these ARGs not been fully explored. In this study, bacterial communities in fish gut, mucosal skin, gill filaments were comprehensively evaluated four different mariculture systems formed by hybrid grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂), Gracilaria bailinae, Litopenaeus...
Although bony fish have CD8+ T cells, the mechanisms by which these early-evolved cytotoxic cells combat intracellular pathogens remain unclear. In present study, using Nile tilapia as a model, we investigated detailed function, mechanism, and evolutionary pattern concerning cells. By depleting they are found essential in combating Edwardsiella piscicida infection. Using siRNA interference, propose that unlike strategy predominantly relying on perforin/granzyme mammals, T-cell effector...
The integration of metabolic programs with T cell signaling establishes a molecular foundation for immune metabolism. As key regulator, GSK3β's activity is dynamically modulated by phosphorylation at Ser9 and Tyr216. However, the contribution these sites on metabolism-driven response remains unclear. Using tilapia mouse models, we investigated regulation GSK3β metabolism its evolutionary variation. In tilapia, activation induces signaling, linking to both glycolysis oxidative (OXPHOS)....
Probiotics are commonly used as nutritional supplements and antibiotic substitutes thus of great commercial interest. The present study was performed to demonstrate the probiotic potential Exiguobacterium acetylicum G1–33 isolated from gut hybrid grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂) by integrating genomics phenotypic traits. In silico genome analysis confirmed its identity acetylicum. Functional annotation revealed existence molecular markers responsible for functional...