A5035657151- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Psoriasis: Treatment and Pathogenesis
- CAR-T cell therapy research
- interferon and immune responses
- Lymphoma Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Sphingolipid Metabolism and Signaling
- Medicinal Plant Pharmacodynamics Research
- Nonmelanoma Skin Cancer Studies
- 14-3-3 protein interactions
- Cancer-related Molecular Pathways
- vaccines and immunoinformatics approaches
- Reproductive System and Pregnancy
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Immunodeficiency and Autoimmune Disorders
Sun Yat-sen University
2019-2024
Waikato District Health Board
2021
Columbia University Irving Medical Center
2015
University of California, San Diego
2010-2014
Abstract Toll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic lupus erythematosus (SLE). However, the molecular mechanism regulating endosomal TLR9 response is incompletely understood. Here, we report that palmitoyl-protein thioesterase 1 (PPT1) regulates autoimmunity by removing S-palmitoylation from lysosomes. PPT1 promotes secretion of IFNα plasmacytoid dendritic cells (pDCs) TNF macrophages. Genetic deficiency or chemical inhibition reduces anti-nuclear...
Metabolic fitness of T cells is essential for their vitality, which largely dependent on the behavior mitochondria. The nature mitochondrial in tumor-infiltrating remains poorly understood. In this study, we show that mitofusin-2 (MFN2) expression positively correlated with prognosis multiple cancers. Genetic ablation Mfn2 CD8+ dampens metabolism and function promotes tumor progression. cells, MFN2 enhances mitochondria-endoplasmic reticulum (ER) contact by interacting ER-embedded...
Disease outcome is known to be influenced by defined subsets of invariant NKT (iNKT) cells residing in distinct locations within peripheral tissue. However, the factors governing development these unique iNKT sublineages during thymic are unknown. In this study we explored mechanism which E protein transcription and their negative regulators, Id proteins, control after positive selection. We found that proteins directly bound promyelocytic leukemia zinc finger (PLZF) promoter were required...
Abstract CCCH zinc finger proteins resolve immune responses by degrading the mRNAs of inflammatory cytokines such as tumor necrosis factor (TNF) and interleukin (IL)-6. Here we report that one family member, monocyte chemotactic protein-induced protein 3 (MCPIP3, also named ZC3H12C or Regnase-3), promotes skin inflammation simultaneously enhancing TNF in macrophages repressing IL-6 plasmacytoid dendritic cells (pDCs). MCPIP3 is positively associated with psoriasis pathogenesis, highly...
Conventional type 1 dendritic cells (cDC1s) are inherently resistant to many viruses but, paradoxically, possess fewer acidic phagosomes that enable antigen retention and cross-presentation. We report palmitoyl-protein thioesterase (PPT1), which catabolizes lipid-modified proteins in neurons, is highly expressed cDC1s. PPT1-deficient DCs more susceptible vesicular stomatitis virus (VSV) infection, mice with PPT1 deficiency cDC1s show impaired response VSV. Conversely, enhance the priming of...
<h3>Background and Objectives</h3> Invariant Natural Killer T (iNKT) cells are able to produce large amounts of cytokines within hours activation. Disease outcome is known be influenced depending on the type produced by iNKT cells. Recently, three functionally transcriptionally defined subsets have been described; TBET + NKT1 IFNg IL-4, while PLZF NKT2 IL-4 IL-13, NKT17 positive for RORγt IL-17. However, factors governing development these unique sublineages during thymic unknown. Here we...
Abstract CD8+ T cells are necessary for immune responses against intracellular pathogens and tumors. The activation of subsequent differentiation into memory populations involves dramatic changes in gene expression. E protein transcription factors their inhibitors, Id proteins, play key roles lymphocyte development, differentiation, maintenance. Specifically, Id2 is upregulated effector maintained presumably to induce function. Interestingly, overexpression also associated with lymphomas....
Abstract STAT proteins regulate homeostatic development of dendritic cells (DCs), yet information about their role in demand situations and mechanisms action remains limited. We found that STATs control cytokine-driven production plasmacytoid (pDCs) conventional DC (cDC) subsets vivo. In progenitor cultures, induce expression the transcriptional regulators E2-2/Tcf4 Id2, which have essential distinct activities pDCs, CD8α+ CD103+ cDCs. Tcf4 is stimulated by Flt3 ligand- (Flt3L) activated...
Abstract Background ‘Skin Shop’ is a model of care at high‐volume tertiary centre that describes registrar‐lead skin cancer service under consultant supervision. Ninety‐two percent lesions are completely excised, 4.2% narrowly excised and 3.2% incompletely excised. Current international guidelines suggest re‐excision non‐melanomatous (NMSC); however, there lack robust evidence to how these should be optimally managed. We describe narrow NMSC managed in the present rates recurrence. Methods...