A5102795070- Yersinia bacterium, plague, ectoparasites research
- Bacillus and Francisella bacterial research
- Bacteriophages and microbial interactions
- Vector-borne infectious diseases
- Bone Tumor Diagnosis and Treatments
- SARS-CoV-2 detection and testing
- Plant-based Medicinal Research
- Gout, Hyperuricemia, Uric Acid
- Selenium in Biological Systems
- Trace Elements in Health
- Congenital limb and hand anomalies
- Zoonotic diseases and public health
- Pharmacological Effects of Natural Compounds
- SARS-CoV-2 and COVID-19 Research
- Medicinal Plant Pharmacodynamics Research
- Biosensors and Analytical Detection
Qinghai Institute for Endemic Diease Prevention and Control
2015-2023
National Health and Family Planning Commission
2023
University of Hong Kong
2022
Plague caused by Yersinia pestis remains a public health threat worldwide. Because multidrug-resistant Y. strains have been found in both humans and animals, phage therapy has attracted increasing attention as an alternative strategy against plague. However, resistance is potential drawback of therapies, the mechanism yet to be investigated. In this study, we obtained bacteriophage-resistant strain (S56) continuously challenging 614F with bacteriophage Yep-phi. Genome analysis identified...
Yersinia pestis is the cause of plague, historically known as "Black Death". Marmota himalayana in Qinghai-Tibet Plateau (QTP) natural plague focus primary host China. Although several phages originating from Y. have been characterized. This first report isolation P2-like M. himalayana. In this study, and characterization three were reported, which named vB_YpM_22, vB_YpM_46 vB_YpM_50. Comparative genome analysis revealed that vB_YpM_50 are members nonlambdoid P2 family, highly similar...
Background Plague, caused by the bacterium Yersinia pestis, is a highly infectious, zoonotic disease. Hundreds of human plague cases are reported across world annually. Qinghai Plateau one most severely affected regions in China, with more than 240 fatal Y. pestis last 60 years. Conventional epidemiologic analysis has effectively guided prevention and control local transmission; however, molecular genetic effective for investigating population diversity transmission. In this report, we...
Yersinia pestis is the etiological agent of plague. Marmota himalayana Qinghai-Tibetan plateau primary host flea-borne Y. pestis. This study report isolation Mu-like bacteriophages from M. himalayana. The and characterization four phages were reported, which named as vB_YpM_3, vB_YpM_5, vB_YpM_6, vB_YpM_23 according to their morphology. Comparative genome analysis revealed that are phylogenetically closest Escherichia coli Mu, D108 Shigella flexneri phage SfMu. role LPS core structure in...
Yersinia pestis is the etiological agent of notorious plague that has claimed millions deaths in history. Of four known Y. biovars (Antiqua, Medievalis, Orientalis and Microtus), Microtus strains are unique pathogenesis for being highly virulent mice but avirulent humans. Here, human peripheral lymphocytes were infected with fully 141 strain or 201, their transcriptomes determined compared. The most notable finding was robust responses pathways cytokine-cytokine receptor interaction,...
Plague, caused by Yersinia pestis, is a natural focus infectious disease. In China, plague classified as category A, with the highest risk and hazard among diseases. Qinghai used to be considered one of most serious areas in China. recent years, thank measures eight aspects summarized "Qinghai model" which were adopted prevent control human Qinghai, has not experienced any case reported for years. early 2020, coronavirus disease 2019 (COVID-19) outbroke The model on was employed deal...
Objective To analyze the radiographic characteristics of right hand X-ray film adult patients with Kaschin-Beck disease (KBD) in Qinghai Province, to understand most affected locations KBD. Methods According criteria KBD diagnose (WS/T 207-2010), 111 cases were taken films hands. Joint space narrow, joint deformity, subchondral sclerosis, osteophyte, coarse and irregularity joint, marginal retraction sign capsule changes chosen as descriptive indexes, these indexes analyzed SPSS...