A5036809604- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Genetic Neurodegenerative Diseases
- Glycogen Storage Diseases and Myoclonus
- Motor Control and Adaptation
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Obsessive-Compulsive Spectrum Disorders
- Vestibular and auditory disorders
- Autoimmune Neurological Disorders and Treatments
- Ophthalmology and Eye Disorders
- Trigeminal Neuralgia and Treatments
- Hereditary Neurological Disorders
- Sleep and Wakefulness Research
- Dysphagia Assessment and Management
- Personality Disorders and Psychopathology
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Nerve injury and regeneration
Université de Toulouse
2010-2025
Inserm
2012-2025
Université Toulouse III - Paul Sabatier
2010-2025
Centre Hospitalier Universitaire de Toulouse
2007-2023
Centre Hospitalier Universitaire de Clermont-Ferrand
2023
Centre National de la Recherche Scientifique
1996-2023
Institut Pascal
2023
Université Clermont Auvergne
2023
Centre National pour la Recherche Scientifique et Technique (CNRST)
2023
Hôpital Paule de Viguier
2022-2023
Patients suffering from Parkinson's disease (PD) describe painful sensations that could be related to neuropathic pain. Experimental data have indicated the involvement of basal ganglia and dopaminergic pathways in central nociceptive processing.The objective this study was assess compare effect levodopa on pain threshold patients with PD healthy subjects.The assessed by flexion reflex (RIII) 13 10 subjects. subjects were evaluated under two randomised conditions: (ON) without (OFF).Levodopa...
SCA27B caused by FGF14 intronic heterozygous GAA expansions with at least 250 repeats accounts for 10-60% of cases unresolved cerebellar ataxia. We aimed to assess the size and frequency expanded alleles in individuals ataxia as compared controls characterize genetic clinical variability.
The frequency of square wave jerks (SWJ) was compared in eight patients with progressive supranuclear palsy (PSP), 25 multiple system atrophy or Parkinson's disease plus (MSA/PP), 85 idiopathic (PD) and 20 age-matched normal volunteers. In the control group, mean (SD) SWJ (SWJ larger than 1 degree amplitude) 2.3 (2.4)/min. Abnormal ocular fixation greater 10/min) observed a large proportion PSP (7/8) MSA/PP (16/25) but few PD (13/85). group abnormal fixation, freezing gait, falls instability...
Abstract We sought to define the influence of ageing in clinical, cognitive, and quality‐of‐life outcomes after subthalamic nucleus deep brain stimulation (STN‐DBS) Parkinson's disease (PD). performed motor assessment (UPDRS), mood tests, quality life evaluation (PDQ‐39) on PD patients before surgery, 12 24 months after, we recorded adverse events. The variations these parameters surgery were correlated with age using regression statistical tests. Cerebral bleeding risk was evaluated by a...
Abstract Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect apomorphine versus placebo on thresholds and pain‐induced cerebral activity 25 patients PD. Subjective threshold (using thermal stimulation, thermotest), objective (nociceptive flexion reflex), (H O PET) during noxious innocuous stimulations were performed. Neither subjective nor...
Background and Objective. The question of the best therapeutic window in which noninvasive brain stimulation (NIBS) could potentiate plastic changes for motor recovery after a stroke is still unresolved. Most previous NIBS studies included patients chronic phase very few subacute or acute phase. We investigated effect transcranial direct current (tDCS) combined with repetitive peripheral nerve (rPNS) on time course stroke. Methods. Twenty enrolled within first days were randomized 2 parallel...
Background. Paired associative stimulation (PAS) combining peripheral nerve and transcranial magnetic (TMS) have been proposed to induce long-term changes in excitability of the cerebral cortex potentially optimize motor recovery stroke patients. Objective. This pilot study examined whether short-lasting cortical could be induced by a single session PAS within first months after stroke. Methods. Six hemiparetic patients with subcortical were included. The protocol was applied at 1, 5, 12...
Doubt, and its behavioural correlate, checking, is a normal phenomenon of human cognition that dramatically exacerbated in obsessive–compulsive disorder. We recently showed deep brain stimulation the associative-limbic area subthalamic nucleus, central core basal ganglia, improved To understand physiological bases symptoms such patients, we recorded activity individual neurons therapeutic target during surgery while subjects performed cognitive task gave them possibility unrestricted...
Local injections of botulinum toxin type A have been used to treat essential head tremor but not extensively studied in randomized trials. In a multicenter, double-blind, trial, we assigned, 1:1 ratio, adult patients with or isolated receive placebo. Botulinum placebo was injected under electromyographic guidance into each splenius capitis muscle on the day randomization (day 0) and during week 12. The primary outcome improvement by at least 2 points Clinical Global Impression Change (CGI)...
1 Heteronymous group II effects were investigated in the human lower limb. Changes firing probability of single motor units quadriceps (Q), biceps (Bi), semitendinosus (ST), gastrocnemius medialis (GM) and tibialis anterior (TA) studied after electrical stimuli between 3 times threshold (MT) applied to common peroneal (CP), superficial (SP) deep (DP) peroneal, Bi GM nerves those nerve-muscle combinations without recurrent inhibition. 2 Stimulation CP evoked almost all explored Q a biphasic...
Repetitive pairing of a peripheral stimulation with magnetic transcortical (PAS) is widely used to induce plastic changes in the human motor cortex noninvasively. Based on contrast between PAS-induced increase corticospinal excitability and absence spinal F wave size, it has been generally accepted that plasticity cortical origin. Here, instead waves, we H reflex recruitment curves assess excitability, demonstrate PAS induces parallel excitability.
Real-life data on response to Botulinum toxin A (BoNT-A) in cervical dystonia (CD) are sparse. An expert group of neurologists was convened with the overall aim developing a definition treatment response, which could be applied non-interventional study BoNT-A-treated subjects CD.International, multicentre, prospective, observational single injection cycle BoNT-A as part normal clinical practice.38 centres across Australia, Belgium, Czech Republic, France, Germany, The Netherlands, Portugal,...
ABSTRACT Objectives The objective of this study was to compare the effect on functional tremor active versus sham repetitive transcranial magnetic stimulation and investigate whether addition hypnosis might help prolong any stimulation–induced therapeutic effect. Methods We compared 5 consecutive daily sessions active/sham tremor, at 1 2 months, in a randomized, double‐blind, 2‐arm, parallel‐controlled study. In second open‐label phase, all patients underwent 3 weekly combined with single...
1 The possibility was investigated that cortical excitation to human thigh motoneurones is relayed via lumbar premotoneurones. 2 Test responses were evoked by transcranial magnetic stimulation (TMS) in voluntarily contracting quadriceps (Q) and semitendinosus (ST) muscles: either a motor potential (MEP) surface recordings or peak of the post-stimulus time histogram (PSTH) single units used. These test conditioned stimuli common peroneal (CP) gastrocnemius medialis (GM) nerves. 3 CP large...
Abstract Background Familial adult myoclonus epilepsy (FAME) is a rare autosomal dominant disorder caused by the same intronic TTTTA/TTTCA repeat expansion in seven distinct genes. TTTTA‐only expansions are benign, whereas those containing TTTCA insertions pathogenic. Objective We investigated genetic basis of cortical without seizures two unrelated families. Methods Repeat‐primed polymerase chain reaction (PCR), long‐range PCR, and nanopore sequencing were used to detect characterize at...