A5003717355- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Botulinum Toxin and Related Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- 3D Printing in Biomedical Research
- Muscle activation and electromyography studies
- Nerve injury and regeneration
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Motor Control and Adaptation
- Neurogenesis and neuroplasticity mechanisms
- Neurological disorders and treatments
- Acute Ischemic Stroke Management
- Vestibular and auditory disorders
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disorders and Treatments
- Mesenchymal stem cell research
- Traumatic Brain Injury Research
- Tissue Engineering and Regenerative Medicine
- Supramolecular Self-Assembly in Materials
- Cellular Mechanics and Interactions
- Musculoskeletal pain and rehabilitation
Inserm
2014-2025
Université Toulouse III - Paul Sabatier
2014-2025
Université de Toulouse
2013-2025
Cognitive Neuroimaging Lab
2019-2022
Imagerie et Cerveau
2019
Imaging Center
2019
Hypertension pulmonaire : physiopathologie et innovation thérapeutique
2017
University of Lausanne
2015
Fondazione Santa Lucia
2015
University of Chieti-Pescara
2015
Abstract In order to determine the influence of a single dose fluoxetine on cerebral motor activation lacunar stroke patients in early phase recovery, we conducted prospective, double‐blind, crossover, placebo‐controlled study 8 with pure hemiparesia. Each patient underwent two functional magnetic resonance imaging (fMRI) examinations: one under and placebo. The first was performed 2 weeks after onset second week later. During fMRI examinations, an active controlled task affected hand...
We compared the rCBF changes induced by execution of a finger-to-thumb opposition motor task in cerebellar hemispheres 12 normal subjects, parkinsonian patients whose medication had been withheld for at least 18 h and 16 on using single photon emission tomography i.v. 133Xe. The subjects exhibited same pattern response, with significant increase contralateral primary cortex supplementary areas. No change was detected cerebellum these two groups; this finding expected since our technique...
Background and Purpose The apparent diffusion coefficient (ADC) of water should be sensitive to the cytotoxic edema triggered by energy failure during ischemia. Elevated values T2, nuclear MR transverse relaxation time water, seen on T2 images detect vasogenic infarcted areas. temporal spatial changes in ADC abnormalities after occlusion middle cerebral artery (MCAO) were therefore estimated these two quantitative techniques. Methods Permanent MCAO was performed rats. Quantitative maps brain...
<h3>Objective:</h3> We hypothesize that the major consciousness deficit observed in coma is due to breakdown of long-range neuronal communication supported by precuneus and posterior cingulate cortex (PCC), prognosis depends on a specific connectivity pattern these networks. <h3>Methods:</h3> compared 27 prospectively recruited comatose patients who had severe brain injury (Glasgow Coma Scale score <8; 14 traumatic 13 anoxic cases) with age-matched healthy participants. Standardized...
3D fabrication techniques are rapidly expanding in the field of scaffold development for cell culture and tissue engineering. Herein we report realization free-standing PEGDA hydrogel architectures by using two-photon lithography. The morphological immunofluorescence characterization neuro2A cells revealed a tridimensional colonization featuring multiple neuritic extensions per as well expression β-tubulin neuronal marker actin microfilaments. results open new perspectives continuous quest...
The realization of 3D architectures for the study cell growth, proliferation, and differentiation is a task fundamental importance both technological biological communities involved in development biomimetic culture environments. Here we report fabrication freestanding scaffolds, realized by multiphoton direct laser writing seeded with neuroblastoma cells, their multitechnique characterization using advanced fluorescence imaging approaches. high accuracy process (≈200 nm) allows much finer...
Repetitive passive movements are part of most rehabilitation procedures, especially in patients with stroke and motor deficit. However, little is known about the consequences repeated proprioceptive stimulations on intracerebral sensorimotor network humans. Twelve healthy subjects were enrolled, all underwent two functional magnetic resonance imaging (fMRI) sessions separated by a 1-month interval. Passive daily movement training was performed six during time between fMRI sessions. The other...
The aim of the current study was to assess reproducibility functional magnetic resonance imaging (fMRI) brain activation signals in a sensorimotor task healthy subjects. Because random or systematic changes are likely happen when movements repeated over time, authors searched for time-dependent fMRI signal intensity and extent within between sessions. Reproducibility studied on called “the active task” that includes motor output sensory feedback, also stimulation passive assessed input...
The first objective of the study was to determine whether functional magnetic resonance imaging (fMRI) signal correlated with motor performance at different stages poststroke recovery. second assess existence prognostic factors for recovery in early MR images. Eight right-handed patients pure deficit secondary a lacunar infarct localized on pyramidal tract were included. This concerned moderately impaired and handgrip strength finger-tapping speed. fMRI task calibrated flexion-extension...
<b>Objective:</b> The ascending reticular activating system (ARAS) modulates circadian wakefulness, which is preserved in a persistent vegetative state (PVS). Its metabolism preserved. Impairment of the polymodal associative cortices (i.e., precuneus) characteristic PVS where awareness abolished. Because interaction these 2 structures allows conscious sensory perception, our hypothesis was that an impaired functional connectivity between them participates loss perception....
Background and Objective. The question of the best therapeutic window in which noninvasive brain stimulation (NIBS) could potentiate plastic changes for motor recovery after a stroke is still unresolved. Most previous NIBS studies included patients chronic phase very few subacute or acute phase. We investigated effect transcranial direct current (tDCS) combined with repetitive peripheral nerve (rPNS) on time course stroke. Methods. Twenty enrolled within first days were randomized 2 parallel...
<h3>Background</h3> Based on the basal ganglia model, it has been hypothesized that efficacy of high-frequency stimulation subthalamic nucleus (STN) against parkinsonian symptoms relies activation cortical premotor regions. In previous positron emission tomography studies, STN was associated with selective midline areas during hand movements but mainly reduced regional cerebral blood flow in movement-related areas, peculiarly at rest. <h3>Objective</h3> To investigate role reduction clinical...
The effects of physiotherapy are difficult to assess in very impaired early stroke patients.The aim the study was characterize impact 4 weeks passive proprioceptive training wrist on brain sensorimotor activation after stroke.Patients with a subcortical ischemic lesion pyramidal tract were randomly assigned control or wrist-training group. All patients had single pure motor hemiplegia severe deficit. group (6 patients) underwent standard Bobath rehabilitation. second, "trained," (7 received...
Background. Paired associative stimulation (PAS) combining peripheral nerve and transcranial magnetic (TMS) have been proposed to induce long-term changes in excitability of the cerebral cortex potentially optimize motor recovery stroke patients. Objective. This pilot study examined whether short-lasting cortical could be induced by a single session PAS within first months after stroke. Methods. Six hemiparetic patients with subcortical were included. The protocol was applied at 1, 5, 12...
Carbon nanotubes (CNTs) promise various novel neural biomedical applications for interfacing neurons with electronic devices or to design appropriate biomaterials tissue regeneration. In this study, we use a new methodology pattern SiO(2) cell culture surfaces double-walled carbon (DWNTs). contrast homogeneous surfaces, patterned allow us investigate phenomena about the interactions between cells and CNTs. Our results demonstrate that thin layers of DWNTs can serve as effective substrates...