A5052885910- Osteoarthritis Treatment and Mechanisms
- Veterinary Equine Medical Research
- Bone Tissue Engineering Materials
- Tendon Structure and Treatment
- Orthopedic Infections and Treatments
- Bone fractures and treatments
- MicroRNA in disease regulation
- Nerve Injury and Rehabilitation
- Probiotics and Fermented Foods
- Proteins in Food Systems
- Corneal Surgery and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Glaucoma and retinal disorders
- Knee injuries and reconstruction techniques
- Nerve injury and regeneration
- Exercise and Physiological Responses
- RNA Interference and Gene Delivery
- Wound Healing and Treatments
- Total Knee Arthroplasty Outcomes
- Ocular Surface and Contact Lens
University of Medicine and Health Sciences
2025
Advanced Materials and BioEngineering Research
2017-2023
Royal College of Surgeons in Ireland
2017-2023
Trinity College Dublin
2017-2023
University of Calgary
2020-2021
Fonterra (New Zealand)
1981
Abstract Osteomyelitis, a severe bone infection, is an extremely challenging complication in the repair of traumatic defects. Furthermore, use long-term high-dose antibiotics standard treatment increases risks antibiotic resistance. Herein, antibiotic-free, collagen silver-doped hydroxyapatite (coll-AgHA) scaffold reinforced with 3D printed polycaprolactone (PCL) framework was developed enhanced mechanical properties to be used load-bearing defects antimicrobial as preventative measure...
Clinically available hollow nerve guidance conduits (NGCs) have had limited success in treating large peripheral injuries. This study aims to develop a biphasic NGC combining physicochemically optimized collagen outer conduit bridge the transected nerve, and neuroconductive hyaluronic acid-based luminal filler support regeneration. The is mechanically by manipulating crosslinking density, allowing engineering of high wall permeability mitigate risk neuroma formation, while also maintaining...
Treating bone infections and ensuring repair is one of the greatest global challenges modern orthopedics, made complex by antimicrobial resistance (AMR) risks due to long-term antibiotic treatment debilitating large defects following infected tissue removal. An ideal multi-faceted solution would will eradicate bacterial infection without use, simultaneously stimulating osteogenesis angiogenesis. Here, a multifunctional collagen-based scaffold that addresses these needs leveraging potential...
Very large bone defects significantly diminish the vascular, blood, and nutrient supply to injured site, reducing bone's ability self-regenerate complicating treatment. Delivering nanomedicines from biomaterial scaffolds that induce host cells produce bone-healing proteins is emerging as an appealing solution for treating these challenging defects. In this context, microRNA-26a mimics (miR-26a) are particularly interesting they target two most relevant processes in regeneration-angiogenesis...
The main reasons for the discontinuation of contact lens wear are ocular dryness and discomfort. Proteoglycan 4 (PRG4), a mucinous glycoprotein, hyaluronic acid (HA), nonsulfated linear glycosaminoglycan, naturally present in eye contribute to hydration lubrication. This study aimed investigate impact structure recombinant human PRG4 (rhPRG4)/HA complex on properties, when one agent is grafted counterpart physisorbed surface model conventional or silicone materials. Investigation...
Purpose: In experimental models of equine joint-injury and osteoarthritis synovial fluid (SF) composition (proteoglycan-4, hyaluronan) can vary, along with changes to SF mechanical function (lubrication, viscosity). The study hypotheses were a) clinical disease results in altered diminished function, b) serum (proteoglycan-4 or concurrently. objectives characterize hyaluronan), from normal horses compared groups: osteoarthritis, acute-joint-injury, osteochondrosis.Materials Methods: Equine...
Objective: Local biological and biomechanical-stimuli modulate proteoglycan-4 secretion within synovial joints. For the horse, changes to concentration function are notable in acute joint injury osteoarthritis. Proteoglycan-4 (also known as Lubricin) is present blood, however effect of exercise on equine serum levels unknown. The overall objective this study was, therefore, investigate intense thoroughbred horses. Methods: Samples blood were taken from thoroughbreds ( n = 12) during a...