A5071287296- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Photoreceptor and optogenetics research
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Retinal and Macular Surgery
- CRISPR and Genetic Engineering
- Retinopathy of Prematurity Studies
- Ophthalmology and Eye Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Systemic Lupus Erythematosus Research
- Drug-Induced Ocular Toxicity
- Glaucoma and retinal disorders
- Autoimmune Neurological Disorders and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Neuroinflammation and Neurodegeneration Mechanisms
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- CNS Lymphoma Diagnosis and Treatment
- Trypanosoma species research and implications
- COVID-19 and Mental Health
- Cerebral Venous Sinus Thrombosis
- Peptidase Inhibition and Analysis
- Axon Guidance and Neuronal Signaling
New York University
2021-2025
Neurology, Inc
2024
NYU Langone Health
2022
Columbia University
2018-2021
Columbia University Irving Medical Center
2018-2021
Cornell University
2018-2020
Weill Cornell Medicine
2018-2020
Palo Alto Veterans Institute for Research
2019
Stanford University
2019
University of Iowa
2019
Little is known about trajectories of recovery 12 months after hospitalization for severe COVID-19. We conducted a prospective, longitudinal cohort study patients with and without neurologic complications during index COVID-19 from March 10, 2020, to May 20, 2020. Phone follow-up batteries were performed at 6 onset. The primary 12-month outcome was the modified Rankin Scale (mRS) score comparing or using multivariable ordinal analysis. Secondary outcomes included activities daily living...
Optical coherence tomography angiography (OCT-A) is a non-invasive alternative to fluorescein that allows for the study of retinal and choroidal vasculatures. In this retrospective cohort 28 patients with retinitis pigmentosa (RP), we used OCT-A quantify changes in perfusion density, foveal avascular zone (FAZ) area, choriocapillaris blood flow over time correlated these variables ellipsoid (EZ) line width best-corrected visual acuity (BCVA). Perfusion density decreased by 2.42 ± 0.62% per...
Background: Metachromatic leukodystrophy (MLD) is a rare autosomal recessive disorder that causes demyelination of both the central (CNS) and peripheral nervous systems (PNS). Objective: This study aims to report unique MLD case presenting with cranial neuropathies ataxia, initially without white matter changes on MRI, leading diagnostic uncertainty. Results: A 20-month-old presented bilateral abduction deficits, facial diplegia, raising possibility an acquired demyelinating condition. An...
This case report describes a 35-year-old female patient experiencing chronic neuropsychiatric symptoms related to kambo , secretion of the South American giant leaf frog, and noted abnormalities on initial magnetic resonance imaging with subsequent resolution.
Optic disc swelling, frequently associated with vitamin A toxicity, is infrequently linked to deficiency. This report describes a 6-year-old male autism spectrum disorder (ASD) and avoidant restrictive food intake who presented xerophthalmia, optic vision changes, deficiencies in vitamins A, B 1 , iron. The patient's behavioral dysregulation posed important challenges for the evaluation, diagnosis, treatment of his hypovitaminoses. case underscores importance considering multiple nutritional...
Background: The RPE65 gene was recently described to cause autosomal dominant retinitis pigmentosa (adRP), presenting with a phenotype resembling choroideremia. This study presents the 2-year progression of adRP in patient.Methods: is an observational case report one patient. patient received full ophthalmic examination during both visits, including diagnostic imaging such as spectral domain optical coherence tomography (SD-OCT), OCT-angiography (OCT-A), short-wave fundus autofluorescence...
We analyze disease progression in retinitis pigmentosa (RP) according to mode of inheritance by quantifying the progressive decrease ellipsoid zone (EZ) line width on spectral domain optical coherence tomography (SD-OCT) and dimensions hyperautofluorescent ring short-wave fundus autofluorescence (SW-FAF). In this retrospective study 96 patients, average follow-up time was 3.2 ± 1.9 years. EZ declined at a rate -123 8 µm per year, while horizontal diameter area rates -131 9 -0.5 0.05 mm2...
Cdc48 (also known as p97 or VCP) is an essential and highly abundant, double-ring AAA+ ATPase, which ubiquitous in archaea eukaryotes. In archaea, ring hexamers play a direct role quality control by unfolding translocating protein substrates into the degradation chamber of 20S proteasome. Whether cooperate directly eukaryotic cells unclear. Two regions are important for binding, pore-2 loop at bottom D2 C-terminal tripeptide. Here, we identify aspartic acid element recognition. Importantly,...
Microglia cells (MGCs) play a key role in scavenging pathogens and phagocytosing cellular debris the central nervous system retina. Their activation, however, contributes to progression of multiple degenerative diseases. Given potential damage created by MGCs, it is important better understand their mechanism activation. Here, we explored MGCs context retinitis pigmentosa (RP) using four independent preclinical mouse models. For therapeutic modeling, tamoxifen-inducible CreER was introduced...
Background and objective: To evaluate the progression of retinitis pigmentosa (RP) caused by mutations in either PDE6A or PDE6B measuring progressive constriction hyperautofluorescent ring shortening ellipsoid zone (EZ)-line width.Patients methods: Fundus autofluorescence (FAF) spectral-domain optical coherence tomography (SD-OCT) images were obtained from seven patients with autosomal recessive RP PDE6B. Measurements EZ line width on SD-OCT horizontal, vertical diameter, area FAF performed...
Abstract Retinitis pigmentosa (RP) is described as a bilateral disease with inter-eye symmetry that presents on short-wavelength fundus autofluorescence (SW-AF) imaging hyperautofluorescent (hyperAF) rings an ellipsoid shape and regular borders. Nevertheless, both asymmetry irregular ring morphologies are also observed. In this retrospective study of 168 RP patients, we characterize the degree frequency hyperAF according to mode inheritance disease-causing gene by using SW-AF spectral-domain...
Purpose: Gyrate atrophy (GA) is a rare chorioretinal degeneration that results in the deterioration of night and peripheral vision, eventually leading to blindness. The disorder caused by mutations gene encoding ornithine aminotransferase (OAT), causing increased levels plasma ornithine. Treatment revolves around lowering levels, with vitamin B6 supplementation being preferred treatment. Nevertheless, most patients do not respond this therapy. Here, we report case B6-responsive GA novel...
Purpose: To compare the detection of retinal pigment epithelium (RPE) atrophy in short-wavelength (SW-AF) and near-infrared autofluorescence (NIR-AF) images Stargardt disease (STGD1) patients. Methods: SW-AF NIR-AF (115 eyes from 115 patients) were analyzed by two independent graders. Hypoautofluorescent (hypoAF) areas, indicative RPE atrophy, measured, modalities compared. Results: Patients segregated into four groups: nascent (6 [5%]), widespread (21 [18%]), discrete (55 [48%]),...