A5055058722- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Nutritional Studies and Diet
- Enhanced Recovery After Surgery
- Nutrition and Health in Aging
- Pharmaceutical Practices and Patient Outcomes
- Skin Protection and Aging
- Birth, Development, and Health
- Health Systems, Economic Evaluations, Quality of Life
- Long-Term Effects of COVID-19
- Pesticide and Herbicide Environmental Studies
- Cardiovascular Syncope and Autonomic Disorders
- Delphi Technique in Research
- Heart Rate Variability and Autonomic Control
- Computational Drug Discovery Methods
- Lipoproteins and Cardiovascular Health
- Renal Transplantation Outcomes and Treatments
- Eicosanoids and Hypertension Pharmacology
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Clinical practice guidelines implementation
- Pesticide Exposure and Toxicity
Humboldt-Universität zu Berlin
2017-2025
Charité - Universitätsmedizin Berlin
2016-2025
Freie Universität Berlin
2017-2025
German Centre for Cardiovascular Research
2021
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2021
Ain Shams University
2016-2018
Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers (Australia), Tine De Backer (Belgium), Alejandro de la Sierra (Spain), Kyriakos Dimitriadis Dorota Drozdz (Poland), Béatrice Duly-Bouhanick (France), Brent M. Egan (USA), Serap Erdine Claudio Ferri (Italy), Slavomira Filipova (Slovak Republic), Anthony Heagerty (UK), Michael Hecht Olsen (Denmark), Dagmara Hering...
Abstract Systemic arterial hypertension (referred to as herein) is a major risk factor of mortality worldwide, and its importance further emphasized in the context novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection referred COVID-19. Patients with COVID-19 infections commonly are older have history hypertension. Almost 75% patients who died pandemic Italy had This raised multiple questions regarding more course relation itself well treatment renin–angiotensin system...
Aim: To measure the extent of polypharmacy, multimorbidity and potential medication-related problems in elderly patients with chronic pain receiving home care. Methods: Data 355 aged ≥65 years affected by care who were enrolled ACHE study Berlin, Germany, analyzed. History diseases, diagnoses, medications including self-medication collected for all patients. Multimorbidity was defined as presence ≥2 conditions levels classified Charlson-Comorbidity-Index. Polypharmacy concomitant intake ≥5...
Background/Objectives: 5-fluorouracil (5-FU) is used in the treatment of solid cancer types. Because its narrow therapeutic window, drug monitoring recommended. We were confronted to answer a question on relevance concentration as opposed area under plasma concentration–time curve (AUC) predict toxicity when we had assess case patient who died after an erroneously high infusion rate. Methods: physiologically-based pharmacokinetic modeling (PBPK) simulate profile 5-FU data doses, dosing...
Systemic arterial hypertension (referred to as herein) is a major risk factor of mortality worldwide, and its importance further emphasized in the context novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection referred COVID-19 Patients with infections commonly are older have history Almost 75% patients who died pandemic Italy had This raised multiple questions regarding more course relation itself well treatment renin-angiotensin system (RAS) blockers, e g...
Introduction : Epidemiological studies in children suggested that utero exposure to chlorpyrifos (CPF), an organophosphate insecticide, may cause developmental neurotoxicity (DNT). We applied quantitative vitro – vivo extrapolation (QIVIVE) based on concentration and non-choline esterase-dependent effects data combined with Benchmark dose (BMD) modelling predict oral maternal CPF during pregnancy leading fetal brain effect concentration. By comparing the results from epidemiological studies,...
To analyze the pattern and appropriateness of pain medications in older adults receiving home care.We performed a prospective cross-sectional study patients ≥65 years old having chronic care Berlin, Germany. Data on prescribed were collected using self-reported information, nursing documents, medication plans during interviews at home. Pain intensity was determined with numeric rating scale (NRS) Assessment In Advanced dementia (PAINAD) scale. The Medication Appropriateness Scale score...
Background Statins substantially reduce the risk of cardiovascular disease when taken regularly. Though statins are generally well tolerated, current studies show that one-third patients discontinue use within 2 years. A qualitative approach may improve understanding attitudes and behaviours towards statins, mechanisms related to discontinuation, how they managed in primary care. Aim To identify factors statin discontinuation approaches for long-term adherence. Design setting study German...
Objective: Common genetic variants in the gene encoding uromodulin (UMOD) have been associated with renal function, blood pressure (BP) and hypertension. We investigated associations between an important single nucleotide polymorphism (SNP) UMOD, that is rs12917707-G>T, estimated glomerular filtration rate (eGFR), BP cardiac organ damage as determined by echocardiography patients arterial Methods: A cohort of 1218 treated high-risk (mean age 58.5 years, 83% men) documented cardiovascular...
Physiologically based kinetic (PBK) modeling has been increasingly used since the beginning of 21st century to support dose selection be in preclinical and clinical safety studies pharmaceutical sector. For chemical assessment, use PBK also found interest, however, a smaller extent, although an internationally agreed document was published already 2010 (IPCS/WHO), but at that time, mostly on vivo data as example IPCS/WHO indicates. Recently, OECD guidance which set standards how...
<h3>Background</h3> Advanced ovarian cancer is managed by extensive surgery, which could be associated with high morbidity. A personalized pre-habilitation strategy combined an 'enhanced recovery after surgery' (ERAS) pathway may decrease post-operative <h3>Primary Objective</h3> To analyze the effects of a multi-modal and ERAS on severe morbidity for patients (primary diagnosis or first recurrence) undergoing cytoreductive surgery. <h3>Study Hypothesis</h3> algorithm entailing physical...
Amiodarone is an antiarrhythmic agent inducing adverse effects on the nervous system, among others. We applied physiologically based pharmacokinetic (PBPK) modeling combined with benchmark dose to predict, published in vitro data, vivo of amiodarone which may lead neurological patients. performed vitro-in extrapolation (IVIVE) from concentrations measured cell lysate a rat brain 3D model using validated human PBPK model. Among observed effects, inhibition choline acetyl transferase (ChAT)...