Elisabetta Furlanis
A5071373100- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Plant Reproductive Biology
- Cannabis and Cannabinoid Research
- Lipid Membrane Structure and Behavior
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- interferon and immune responses
- Sperm and Testicular Function
- Neuropeptides and Animal Physiology
- SARS-CoV-2 and COVID-19 Research
Harvard University
2022-2025
Broad Institute
2024-2025
Boston VA Research Institute
2024
University of Basel
2016-2023
SUMMARY In recent years, we and others have identified a number of enhancers that, when incorporated into rAAV vectors, can restrict the transgene expression to particular neuronal populations. Yet, viral tools access manipulate fine subtypes are still limited. Here, performed systematic analysis single cell genomic data identify enhancer candidates for each cortical interneuron subtypes. We established set enhancer-AAV that highly specific distinct populations striatal cholinergic neurons....
The specification of synaptic properties is fundamental for the function neuronal circuits. "Terminal selector" transcription factors coordinate terminal gene batteries that specify cell-type-specific properties. Moreover, pan-neuronal splicing regulators have been implicated in directing differentiation. However, cellular logic how instruct specific remains poorly understood. Here, we combine genome-wide mapping mRNA targets and loss-of-function studies to uncover contribution RNA-binding...
SUMMARY Within the adult rodent hippocampus, opioids suppress inhibitory parvalbumin-expressing interneurons (PV-INs), thus disinhibiting local micro-circuits. However, it is unknown if this disinhibitory motif conserved in other cortical regions, species, or across development. We observed that PV-IN mediated inhibition robustly suppressed by hippocampus proper but not primary neocortex mice and nonhuman primates, with spontaneous tone resected human tissue also following a consistent...
Summary The recognition of synaptic partners and specification properties are fundamental for the function neuronal circuits. ‘Terminal selector’ transcription factors coordinate expression terminal gene batteries that specify cell type-specific properties. Moreover, pan-neuronal alternative splicing regulators have been implicated in directing differentiation. However, cellular logic how instruct specific remains poorly understood. Here, we combine genome-wide mapping mRNA targets...