A5103104059- Mosquito-borne diseases and control
- Malaria Research and Control
- Insect Pest Control Strategies
- Viral Infections and Vectors
- Travel-related health issues
- Vector-borne infectious diseases
- Drug-Induced Hepatotoxicity and Protection
- Agricultural pest management studies
- COVID-19 and Mental Health
- Dengue and Mosquito Control Research
- Digital Imaging for Blood Diseases
- Insect Resistance and Genetics
- Fish Biology and Ecology Studies
- Identification and Quantification in Food
- Hepatitis C virus research
- COVID-19 Pandemic Impacts
- Child Nutrition and Water Access
- DNA Repair Mechanisms
- Parasites and Host Interactions
- Protein Kinase Regulation and GTPase Signaling
- Global Maternal and Child Health
- Digestive system and related health
- Invertebrate Immune Response Mechanisms
- Hepatitis B Virus Studies
- Livestock and Poultry Management
National Institute of Malaria Research
2014-2024
Academy of Scientific and Innovative Research
2024
National Institute of Epidemiology
2011-2024
Indian Council of Medical Research
2014-2024
Sri Ramachandra Institute of Higher Education and Research
2022
State University of New York
2015
University of Washington
2015
University of Iowa
1997-1998
A major public health question is whether urbanization will transform malaria from a rural to an urban disease. However, differences about definitions of settings, malaria, and control should differ between areas complicate both the analysis available data development intervention strategies. This report examines approach International Centers Excellence for Malaria Research (ICEMR) in Brazil, Colombia, India (Chennai Goa), Malawi, Senegal, Uganda. Its theme need determine cases diagnosed...
DNA damage and replication stress activate the Chk1 signaling pathway, which blocks S phase progression, stabilizes stalled forks, participates in G2 arrest. In this study, we show that interacts with Hsp90, a molecular chaperone folding, assembly, maturation, stabilization of specific proteins known as clients. Consistent being an Hsp90 client, also found but not Chk2 is destabilized cells treated inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG). 17-AAG-mediated loss blocked...
The Indian city of Chennai is endemic for malaria and the known local vector Anopheles stephensi. Plasmodium vivax predominant parasite species, though falciparum present at low levels. urban ecotype prevails in with perennial transmission despite surveillance by Urban Malaria Scheme (UMS) National Vector Borne Disease Control Programme (NVBDCP). Understanding feeding resting preferences, together potential adult vectors area essential effective planning execution improved control measures.A...
Wells and overhead tanks (OHT) are the major breeding sources of local malaria vector, Anopheles stephensi in Indian city Chennai; they play a significant role vector breeding, transmission urban malaria. Many other man-made habitats, such as cemented cisterns/containers, barrels or drums, sumps underground tanks, plastic pots/containers maintained to supplement water needs, temporarily resulting enhanced mosquito/vector breeding. Correlating habitats with immature abundance is important...
Abstract Malaria in India, while decreasing, remains a serious public health problem, and the contribution of submicroscopic asymptomatic infections to its persistence is poorly understood. We conducted community surveys clinic studies at three sites India differing their eco-epidemiologies: Chennai (Tamil Nadu), Nadiad (Gujarat), Rourkela (Odisha), during 2012–2015. A total 6,645 subject blood samples were collected for Plasmodium diagnosis by microscopy PCR, an extensive clinical...
The global temperature has significantly risen in the past century. Studies have indicated that higher intensifies malaria transmission tropical and temperate countries. Temperature fluctuations will a potential impact on parasite development vector Anopheles mosquito.
Identification of a new family proteins (RGS proteins) that function as negative regulators ofG protein signaling has sparked understanding desensitization this process. Recent studies with several mammalian RGS delineated their ability to interact and GTPase-activating specifically for G in the Gi family. Here, we investigated functional activity RGS3 truncated form on protein-coupled receptor-mediated activation adenylyl cyclase, phosphoinositide phospholipase C, mitogen-activated kinase...
Environmental temperature is an important driver of malaria transmission dynamics. Both the parasite and vector are sensitive to mean ambient temperatures daily variation. To understand ecology, therefore, it determine range microclimatic experienced by vectors in field.A pilot study was conducted Indian city Chennai variation urban microclimates characterize thermal ecology local setting. Temperatures were measured a probable indoor outdoor resting habitats Anopheles stephensi two slum...
Mass distributions of long-lasting insecticidal nets (LLINs) have contributed to large reductions in the malaria burden. However, this success is jeopardy due part increasing pyrethroid-resistant mosquito population as well low LLINs coverage various areas because lifespan often shorter than interval between replenishment campaigns. New insecticide-treated (ITNs) containing pyrethroid and piperonyl-butoxide (PBO) shown a greater reduction incidence with mosquitoes. durability (attrition,...
Rad17, Rad1, Hus1, and Rad9 are key participants in checkpoint signaling pathways that block cell cycle progression response to genotoxins. Biochemical molecular modeling data predict Rad9, Rad1 form a heterotrimeric complex, dubbed 9-1-1, which is loaded onto chromatin by complex of Rad17 the four small replication factor C (RFC) subunits (Rad17-RFC) DNA damage. It unclear what proteins or events regulate association 9-1-1 with DNA. Here we show genotoxin-induced binding does not require...
Female Anopheles culicifacies Giles from Ramanathapuram district, Tamil Nadu state, India, were examined for oocysts and sporozoites their larval progeny mitotic karyotype. Collections made Mandapam Uchipuli on the mainland, Thangachimadam Pamban Rameshwaram Island. Of 451 An. females that collected dissected, 24 found positive Plasmodia (21 3 oocysts). Both acrocentric submetacentric Y-chromosome karyotypes observed among of all villages. All 11 iso-female lines whose parental or had with...
Among the four human malaria parasites, drug resistance occurs mainly in Plasmodium falciparum. However, there are some reports of chloroquine (CQ) P. vivax from different geographical regions. In India, approximately 50% a total 2 million cases reported annually due to vivax. CQ is choice for treatment. Since few treatment failure have been this study was undertaken generate data systematically on efficacy 287 patients epidemiological Cure rates 28 days were 100% and rapid parasite...
Assessing the Plasmodium vivax burden in India is complicated by potential threat of an emerging chloroquine (CQ) resistant parasite population from neighbouring countries Southeast Asia. Chennai, capital Tamil Nadu and urban setting for P. southern India, was selected as a sentinel site investigating CQ efficacy sensitivity malaria. evaluated with 28-day vivo therapeutic study, while measured vitro drug susceptibility assay. In both studies, isolates also underwent molecular genotyping to...
The unprecedented global efforts for malaria elimination in the past decade have resulted altered vectorial systems, vector behaviors, and bionomics. These changes combined with increasingly evident heterogeneities transmission require innovative control strategies addition to established practices of long-lasting insecticidal nets indoor residual spraying. Integrated management will focal tailored achieve elimination. This switch emphasis from universal coverage plus additional...
Repellents such as coils, vaporizers, mats and creams can be used to reduce the risk of malaria other infectious diseases. Although evidence for their effectiveness is limited, they are advertised providing an additional approach mosquito control in combination with strategies, e.g. insecticide-treated nets. We examined use repellents India urban setting Chennai (mainly Plasmodium vivax malaria), a peri-urban Nadiad (both P. falciparum more rural Raurkela malaria). The was at household level...
Environmental factors such as temperature, relative humidity and their daily variation influence a range of mosquito life history traits hence, malaria transmission. The standard way characterizing environmental with meteorological station data need not be the actual microclimates experienced by mosquitoes within local transmission settings. A year-long study was conducted in Chennai, India to characterize temperature (RH). Data loggers (Hobos) were placed probable indoor outdoor resting...
Abstract Background Chloroquine resistance (CQR) phenotype in Plasmodium falciparum is associated with mutations pfcrt and pfmdr-1 genes. Mutations at amino acid position 72-76 of gene, here defined as haplotype are the geographic origin chloroquine resistant parasite. Here, codon 220 gene N86Y mutation were studied blood samples collected across 11 field sites, inclusive high low P. prevalent areas India. Any probable correlation between these clinical outcome CQ treatment was also...
Understanding naturally acquired immune responses to Plasmodium in India is key improving malaria surveillance and diagnostic tools. Here we describe serological profiling of at three sites by probing protein microarrays consisting 515 vivax 500 falciparum proteins with 353 plasma samples. A total 236 malaria-positive (symptomatic asymptomatic) samples 117 malaria-negative were collected field Raurkela, Nadiad, Chennai. Indian showed significant seroreactivity 265 P. 373 antigens, but...
Abstract Background Karnataka is one of the largest states in India and has a wide range geographical terrains, ecotypes, prevalence malaria. It experiences voluminous influx efflux people across state that affects spread The deployed focused intervention measures keeping national objective malaria elimination as foremost priority. This brought down cases below thousand by year 2021. Furthermore, motivated toward 2025. study analyzes trends indices over past three decades highlights key...