A5045773865- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- Lung Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Nanoplatforms for cancer theranostics
- Cardiovascular Disease and Adiposity
- bioluminescence and chemiluminescence research
- MRI in cancer diagnosis
- Cardiac electrophysiology and arrhythmias
- Viral Infectious Diseases and Gene Expression in Insects
- Lung Cancer Treatments and Mutations
- Cardiac tumors and thrombi
- Head and Neck Cancer Studies
- Cancer Research and Treatments
- Protease and Inhibitor Mechanisms
- Medical Imaging and Pathology Studies
- Genetic factors in colorectal cancer
- Atomic and Subatomic Physics Research
- Thyroid Cancer Diagnosis and Treatment
Kawasaki Medical School
2014-2024
National Institutes for Quantum Science and Technology
2011-2013
Imaging Center
2012
Hamamatsu Medical Center
2010
Translational Research Informatics Center (Japan)
2005-2009
Kyoto University
1997-2009
Hamamatsu Photonics (Japan)
2004-2009
Hokkaido University
2006-2008
University of California, Los Angeles
2002-2006
UCLA Jonsson Comprehensive Cancer Center
2002
Background — Imaging reporter gene expression is useful for noninvasive monitoring of therapy. In this study, we imaged cardiac in living rats using micro positron emission tomography (microPET). Methods and Results Rats (n=10) underwent intramyocardial injection with 1×10 9 pfu adenovirus carrying cytomegalovirus promoter-driving herpes simplex virus type 1 mutant thymidine kinase (Ad-CMV-HSV1-sr39tk) as PET gene. Control (n=4) received firefly luciferase (Ad-CMV-Fluc). On days 2 to 4,...
Background — Studies of cardiac gene transfer rely on postmortem analysis using histologic staining or enzyme assays. Noninvasive imaging the temporal and spatial characteristics expression in same subject offers significant advantages. Methods Results Rats underwent direct myocardial injection via left thoracotomy with adenovirus-expressing firefly luciferase (Ad-CMV-Fluc; n=30). The reporter substrate d -luciferin was injected intraperitoneally. Serial images were acquired by use a cooled...
Background— This study examines the quantitative accuracy, detection sensitivity, and time course of imaging expression a mutant herpes simplex type-1 virus thymidine kinase (HSV1-sr39tk) PET reporter gene in rat myocardium by using probe 9-(4-[ 18 F]-Fluoro-3-Hydroxymethylbutyl)-Guanine ([ F]-FHBG) small-animal (microPET). Methods Results— In 40 rats, adenovirus expressing HSV1-sr39tk driven cytomegalovirus promoter (Ad-CMV-HSV1-sr39tk, 1×10 6 to 9 pfu) was injected through thoracotomy...
As 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is becoming a common imaging modality, the number of thyroid incidentalomas identified by FDG-PET (PET incidentaloma) increasing. The purpose this study was to elucidate risk cancer in focal PET incidentaloma healthy subjects relatively younger age as well usefulness repeated FDG-PET. conducted with an observation period three years. A total 1,501 volunteers (mean age, 43.5+/-9.7 years) underwent first from August 2003 July...
Background — We explored the feasibility of measuring regional tracer activity concentrations and flow defects in myocardium rats with a high spatial resolution small-animal PET system (microPET). Methods Results Myocardial images were obtained after intravenous 18 F-fluorodeoxyglucose ( FDG) 11 normal (group 1) assembled into polar maps. Regional F measured 9 regions interest compared tissue by well counting. In another 2), myocardial perfusion acquired 13 N -ammonia at baseline during...
Purpose To prospectively evaluate the utility of whole-body cancer screening with multiple modalities including [ 18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) in a healthy population. This report summarizes results first three annual screenings. Participants and Methods A total 1,197 volunteers ≥ 35 years old were enrolled between August 2003 July 2004 offered for 5 subsequent long-term follow-up. Screening included FDG-PET, chest abdominal computed (CT), brain pelvic...
Cardiac sympathetic function plays an important role in the regulation of left ventricular (LV) and pathophysiology LV dysfunction. (11)C-CGP-12177 ((11)C-CGP) has been used to assess myocardial beta-adrenergic receptor (beta-AR) density vivo using PET. The aim this study is measure beta-AR patients with nonischemic cardiomyopathy compare measurements various standard parameters heart failure (HF), particularly presynaptic assessed by (123)I- metaiodobenzylguanidine ((123)I-MIBG)...
This study evaluated the prognostic value of positron emission tomography/computed tomography (PET/CT) using (18) F-fluoroazomycin arabinoside (FAZA) in patients with advanced non-small-cell lung cancer (NSCLC) compared F-fluorodeoxyglucose (FDG). Thirty-eight NSCLC (stage III, 23 patients; stage IV, 15 patients) underwent FAZA and FDG PET/CT before treatment. The PET parameters (tumor-to-muscle ratio [T/M] at 1 2 h for FAZA, maximum standardized uptake FDG) primary lesion lymph node (LN)...
Abstract Objective The optimization of medical exposure is one the major issues regarding radiation protection in world, and International Committee Radiological Protection Atomic Energy Agency recommend establishing diagnostic reference levels (DRLs) as tools for dose optimization. Therefore, development DRLs based on latest survey has been required nuclear medicine-related societies organizations. This prompted us to conduct a nationwide actual administered radioactivity adults purpose...