A5085004702- Nanoplatforms for cancer theranostics
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Gastrointestinal Tumor Research and Treatment
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- Esophageal Cancer Research and Treatment
- Inflammatory mediators and NSAID effects
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- Vascular Malformations and Hemangiomas
- Medicinal plant effects and applications
- Advanced biosensing and bioanalysis techniques
- Biological Activity of Diterpenoids and Biflavonoids
- Enhanced Recovery After Surgery
- Cancer Research and Treatments
Southern Medical University
2020-2023
Nanfang Hospital
2020-2023
Key Laboratory of Guangdong Province
2020
Guangzhou Medical University
2017-2018
Second Affiliated Hospital of Guangzhou Medical University
2017-2018
Peritoneal metastasis predicts poor prognosis of gastric cancer (GC) patients, and the underlying mechanisms are poorly understood.
Abstract Background CuS-modified hollow mesoporous organosilica nanoparticles (HMON@CuS) have been preferred as non-invasive treatment for cancer, near infrared (NIR)-induced photo-thermal effect (PTT) and/or photo-dynamic (PDT) could increase cancer cells’ apoptosis. However, the certain role of HMON@CuS-produced-PTT&PDT inducing gastric (GC) mitochondrial damage, remained unclear. Moreover, theranostic efficiency HMON@CuS might be well improved by applying multi-modal imaging, which...
Abstract Background Paclitaxel (PTX) has been suggested to be a promising front-line drug for gastric cancer (GC), while P-glycoprotein (P-gp) could lead resistance by pumping PTX out of GC cells. Consequently, it might hopeful way combat inhibiting the out-pumping function P-gp. Results In this study, we developed delivery system incorporating onto polyethylene glycol (PEG)-modified and oxidized sodium alginate (OSA)-functionalized graphene oxide (GO) nanosheets (NSs), called...
To investigate whether Dihydromyricetin (DHM) inhibits cell proliferation and promotes apoptosis by downregulating Notch1 expression.The correlation between Hes1 (a target molecule) expression in hepatoma samples was confirmed qRT-PCR. In addition, MTT assays, flow cytometry TUNEL analysis showed that DHM possessed strong anti-tumor properties, evidenced not only reduced but also enhanced QGY7701 HepG2 hepatocellular carcinoma (HCC) cells. The expressions of Notch1, Hes1, Bcl-2 Bax were...
Abstract Background The benefits of adjuvant chemotherapy for elderly patients with gastric cancer (GC) remain unknown because are underrepresented in most clinical trials. This study aimed to evaluate the effectiveness and complications > 65 years age after laparoscopic D2 gastrectomy. Methods was a single-center retrospective cohort (> years) stage II/III GC who underwent curative gastrectomy R0 resection between 2004 2018. regimens included monotherapy (oral capecitabine) doublet...
Background The specific efficacy of immunotherapy for patients with liver metastases gastric cancer is unclear. This study set out to explore the treatment response and related prognostic factors treated immunotherapy. Patients methods retrospective cohort included 135 unresectable advanced cancer. According presence and/or first-line immunotherapy, were divided into following three groups: I-LM(-) group(patients without n=66), I-LM(+) n=36), C-LM(+) chemotherapy target therapy, n=33). Cox...
Abstract Background: Laparoscopic distal gastrectomy (LDG) has been highlighted for its safety and better short-term clinical outcomes in treating gastric cancer. However, only a slight reduction of the post-operative hospital stay was observed cancer patients undergoing LDG with conventional perioperative management, compared to open surgery. Thus, an enhanced recovery after surgery (ERAS) program is needed further reduce stays. This prospective, open-label, single-arm cohort study aimed...
Purpose: Lymphadenectomy with lymph node (LN) mapping is essential for surgical removal of solid tumors. Existing agents do not provide accurate multimodal and antitumor therapy metastatic LNs; therefore, we fabricated a polydopamine (PDA) nanoparticle (NP)-based tumor-targeted LN agent capable guided photothermal (PTT) LNs. Materials Methods: PDA NPs modified polyethylene glycol (PEG) were obtained by polymerization under alkaline conditions. The PEG-PDA loaded the circular tripeptide...
Abstract BackgroundPaclitaxel (PTX) has been suggested to be a promising front-line drug for gastric cancer (GC), while P-glycoprotein (P-gp) could lead resistance by pumping PTX out of GC cells. Consequently, it might hopeful way combat inhibiting the out-pumping function P-gp. ResultsIn this study, we developed delivery system incorporating onto polyethylene glycol (PEG)-modified and oxidized sodium alginate (OSA) -functionalized graphene oxide (GO) nanosheets (NSs), called PTX@GO-PEG-OSA....
Abstract Background: CuS-modified hollow mesoporous organosilica nanoparticles (HMON@CuS) have been preferred as non-invasive treatment for cancer, near infrared (NIR)-induced photo-thermal effect (PTT) and/or photo-dynamic (PDT) could increase cancer cells’ apoptosis. However, the certain role of HMON@CuS-produced-PTT&PDT inducing gastric (GC) mitochondrial damage, remained unclear. Moreover, theranostic efficiency HMON@CuS might be well improved by applying multi-modal imaging, which...
Abstract Background : The benefits of adjuvant chemotherapy for elderly patients (age >65) with gastric cancer (GC) remain unknown because are underrepresented in most clinical trials. To evaluate the effectiveness and complications (>65 years age) after laparoscopic D2 gastrectomy. Methods This was a retrospective cohort study years) stage II/III GC who underwent curative gastrectomy between 2004 2018. were divided as surgery alone plus (chemo group). overall survival (OS),...
Abstract CuS-modified hollow mesoporous organosilica nanoparticles (HMON@CuS) have been preferred as non-invasive treatment for cancer, near infrared (NIR)-induced photo-thermal effect (PTT) and/or photo-dynamic (PDT) could increase cancer cells’ apoptosis. However, the certain role of HMON@CuS-produced-PTT&PDT inducing gastric (GC) mitochondrial fusion, remained unclear. Moreover, theranostic efficiency HMON@CuS might be well improved by applying multi-modal imaging which offer an optimal...
An amendment to this paper has been published and can be accessed via the original article.