A5005288854- Oral and Maxillofacial Pathology
- Cancer Diagnosis and Treatment
- Dermatological and COVID-19 studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Periodontal Regeneration and Treatments
- Dental Research and COVID-19
- Parvovirus B19 Infection Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Oral health in cancer treatment
- dental development and anomalies
- Bone Tumor Diagnosis and Treatments
- Mesenchymal stem cell research
- Bone and Dental Protein Studies
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- COVID-19 epidemiological studies
- COVID-19 diagnosis using AI
- Bone health and treatments
- Oral microbiology and periodontitis research
- Bone Tissue Engineering Materials
- Dental Health and Care Utilization
- Infection Control in Healthcare
Universidade Federal de Minas Gerais
2021-2023
Universidade de São Paulo
2010-2022
Instituto de Ciencias Tecnológicas
2021
Instituto Butantan
2019
Faculdade São Leopoldo Mandic
2010
Oral squamous cell carcinoma (OSCC) is an extremely aggressive disease associated with a poor prognosis. Previous studies have established that cancer stem cells (CSCs) actively participate in OSCC development, progression and resistance to conventional treatments. Furthermore, CSCs frequently exhibit deregulated expression of normal signalling pathways, thereby acquiring their distinctive abilities, which self-renewal example. In this study, we examined the effects GLI3 knockdown OSCC, as...
Abstract Background Tongue squamous cell carcinoma (SCC) contains a subpopulation referred to as cancer stem cells (CSCs), which are responsible for tumor growth, metastasis, and resistance chemotherapy radiotherapy. The CSC markers have been used isolate these biomarkers predict overall survival. Methods CD44, NANOG, OCT4, BMI1 were investigated using reverse transcriptase‐quantitative polymerase chain reaction (RT‐qPCR) immunohistochemistry correlated with clinicopathological parameters....
Abstract The emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants concern (VOCs) have been described as the main factor driving Coronavirus Disease 2019 pandemic. In Brazil, Gamma variant dominated epidemiological scenario during first period 2021. Many Brazilian regions detected Delta after its description documented spread. To monitor introduction spread VOC Delta, we performed Polymerase Chain Reaction (PCR) genotyping genome sequencing in...
Carcinoma ex pleomorphic adenoma (CXPA) is a rare malignant salivary gland tumor derived from pre-existing adenoma. It good model to study the evolution of carcinogenesis, starting with in situ areas frankly invasive carcinoma. Growth factors are associated several biological and neoplastic processes by transmembrane receptors. In order investigate, immunohistochemistry, expression some growth its receptors [EGF receptor, fibroblast factor, factor receptor 1, 2, hepatocyte c-Met,...
Natural triterpenes exhibit a wide range of biological activities. Since this group secondary metabolites is structurally diverse, effects may vary due to distinct biochemical interactions within systems. In work, we investigated the anticancer-related activities quinone-methide triterpene maytenin and its derivative compound 22-β-hydroxymaytenin, obtained from Maytenus ilicifolia roots cultivated in vitro. Their antiproliferative pro-apoptotic were evaluated monolayer three-dimensional...
Central giant cell granulomas (CGCG) of the jaws are osteolytic lesions that may behave aggressively and respond poorly to surgery. Microscopically, in addition cells, there is a mononuclear population composed macrophage/monocytic cells spindle-shaped mesenchymal origin. Seventy two percent these tumours harbour mutually exclusive TRPV4, KRAS FGFR1 mutations. We aimed assess mutational status osteogenic potential stromal vitro vivo.We screened CGCG for signature mutations used laser-capture...
Myoepithelial cells have an important role in salivary gland tumor development, contributing to a low grade of aggressiveness these tumors. Normal myoepithelial are known by their suppressor function presenting increased expression extracellular matrix genes and protease inhibitors. The importance stromal growth factors during initiation progression has been highlighted recent literature. Many tumors result from the alteration paracrine pathways. Growth mediate wide variety biological...
Background The coronavirus disease 2019 (COVID-19) pandemic had quite an impact on dental health care. Concerns about the risk of SARS-CoV-2 transmission through contaminant fluids and droplet formation during several procedures highly impacted care, drastically reducing number practices worldwide. To monitor contamination in clinics, a longitudinal study was carried out return practice at university. Methods Dental care professionals [(DHCPs); teachers, undergraduate students, assistants]...
Most patients with head and neck cancer receive nonsteroidal anti-inflammatory drugs concomitant oncogenic treatment in order to control cardiovascular diseases chronic inflammatory processes. Inflammation is closely related neoplastic development the release of cytokines chemokines represents a crucial event this relationship. The aim present study was evaluate effect acetylsalicylic acid (ASA) celecoxib gene expression pattern squamous cell carcinoma (OSCC) lines.Cells were treated...
The COVID-19 pandemic has created an unprecedented need for epidemiological monitoring using diverse strategies. We conducted a project combining prevalence, seroprevalence, and genomic surveillance approaches to describe the initial stages in Betim City, Brazil. collected 3239 subjects population-based age-, sex- neighborhood-stratified, household, prospective; cross-sectional study divided into three surveys 21 days apart sampling same geographical area. In first survey, overall prevalence...
ABSTRACT Dental caries is a non-communicable disease and considered public health problem. For diagnosis correct treatment, the study of risk assessment activity necessary. The way to formalize balance imbalance predictably diagnose dental caries. Therefore, performed through different evaluation systems. Another parameter great importance be studied caries, because it done treatment decision for patient. objective this article inform reader about: concepts factors; systems described in...
Since its first identification in Brazil, the variant of concern (VOC) Gamma has been associated with increased infection and transmission rates, hospitalizations, deaths. Minas Gerais (MG), second-largest populated Brazilian state more than 20 million inhabitants, observed a peak cases deaths March–April 2021. We conducted surveillance study 1240 COVID-19-positive samples from 305 municipalities distributed across MG’s 28 Regional Health Units (RHU) between 1 March to 27 April The most...
Abstract Background Three years after the first confirmed COVID‐19 case in Brazil, outcomes of Federal government omissions managing crisis and anti‐science stance heading into pandemic have become even more evident. With over 36 million cases nearly 700 000 deaths up to January 2023, country is one hardest‐hit places world. The lack mass‐testing programs was a critical broken pillar responsible for quick uncontrolled SARS‐CoV‐2 spread throughout Brazilian population. Faced with this...