A5011289806- Statistical Methods in Clinical Trials
- Statistical Methods and Bayesian Inference
- Pharmacogenetics and Drug Metabolism
- Statistical Methods and Inference
- Asthma and respiratory diseases
- Optimal Experimental Design Methods
- Rheumatoid Arthritis Research and Therapies
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory and Cough-Related Research
- Pharmaceutical studies and practices
- Receptor Mechanisms and Signaling
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Hormonal Regulation and Hypertension
- Advanced Statistical Methods and Models
- Advanced Causal Inference Techniques
- Anesthesia and Sedative Agents
- Analytical Chemistry and Chromatography
- Drug Transport and Resistance Mechanisms
- Hemodynamic Monitoring and Therapy
- Epilepsy research and treatment
- Statistical and Computational Modeling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Computational Drug Discovery Methods
- Optimization and Packing Problems
Umeå University
1990-2019
Uppsala University
2002-2013
Roche (Switzerland)
2006-2007
University of California, San Francisco
2002
Luleå University of Technology
2001
Science for Life Laboratory
2001
Karlstad Central Hospital
1997
National Institute of Occupational Health
1994
The aim of this study was to compare 2 stepwise covariate model-building strategies, frequently used in the analysis pharmacokinetic-pharmacodynamic (PK-PD) data using nonlinear mixed-effects models, with respect included covariates and predictive performance. In addition, effects regression on estimated coefficients wise were assessed. Using simulated real PK data, models built applying (1) generalized additive (GAM) for identifying potential covariates, followed by backward elimination...
Objectives This study assessed dietary habits and exposure to selenium, persistent organochlorine compounds, methylmercury, methylamines among Swedish fishermen. Methods Two hundred fifty randomly selected subjects from a cohort of 2896 fishermen the east coast (Baltic Sea) 8477 west (Skagerrak Kattegatt) were interviewed along with 250 referents. Subgroups referents different coastal areas also for blood urine sampling. Results The interview data showed that ate almost twice as much fish...
The aim of this study was to characterize the relationship between warfarin concentrations and international normalized ratio (INR) response identify predictors important for dose individualization. S- R-warfarin concentrations, INR, CYP2C9 VKORC1 genotypes from 150 patients were used develop a population pharmacokinetic/pharmacodynamic model in NONMEM. anticoagulant best described by an inhibitory E(MAX) model, with S-warfarin concentration as only exposure predictor response. Delay...
The objective of this study was to compare the blood-brain barrier (BBB) transport and brain distribution levo- (<i>R</i>-CZE) dextrocetirizine (<i>S</i>-CZE). Microdialysis probes, calibrated using retrodialysis by drug, were placed into frontal cortex right jugular vein eight guinea pigs. Racemic CZE (2.7 mg/kg) administered as a 60-min i.v. infusion. Unbound total concentrations enantiomers measured in blood with liquid chromatography-tandem mass spectrometry. compared parameters...
We propose a model that characterizes and links the complexity diversity of clinically observed hepatitis C viral kinetics to sustained virologic response (SVR)—the primary clinical end point treatment, defined as an undetectable load at 24 weeks after completion treatment)—in patients with chronic (CHC) who have received treatment peginterferon α-2a ± ribavirin. The new attributes our kinetic are (i) implementation cure/viral eradication boundary, (ii) employment all virus (HCV) RNA...
The objective of the study was to update a previous NONMEM model describe relationship between warfarin dose and international normalized ratio (INR) response, decrease dependence on pharmacokinetic (PK) data, improve characterization rare genotype combinations. effects age CYP2C9 S-warfarin clearance were estimated from high-quality PK data. Thereafter, temporal dose-response (K-PD) developed information dose, INR, age, VKORC1 genotype, with drug as covariate. Two transit compartment chains...
Warfarin is the most widely prescribed anticoagulant for prevention and treatment of thromboembolic events. Although highly effective, use warfarin limited by a narrow therapeutic range combined with more than ten-fold difference in dose required adequate anticoagulation adults. An optimal that leads to favourable balance between wanted antithrombotic effect risk bleeding as measured prothrombin time International Normalised Ratio (INR) must be found each patient. A model describing...
Abstract Covariate modeling is an important opportunity for pharmacometrics to influence decision making in drug development. The stepwise covariate model (SCM) building procedure the most common method Despite its advantages, traditional SCM known have long runtimes and suboptimal ability select relevant covariates, especially more complex phase III settings. In this work, two alternative approaches are presented: SCM+, which introduces “adaptive scope reduction” changes general estimation...
<h3>BACKGROUND</h3> Remission of asthma in adults has been considered to be low but is still not well documented. In children remission occurs with a rate estimated at approximately 50%. middle aged and elderly subjects was investigated as part population based study respiratory diseases Northern Sweden. <h3>METHODS</h3> 1986 86% 6610 participated questionnaire survey. After clinical validation 300 were diagnosed having current asthma. 1996 5935 the cohort could traced for third survey 87%...
QT prolongation is an important biomarker of the arrhythmia torsades de pointes and appears to be related mainly blockade delayed inward cardiac rectifier potassium currents. The aim this study was quantify relationship between in vitro human ether-a-go-go-related gene (hERG) channel magnitude humans for class III antiarrhythmic dofetilide.The affinity activity dofetilide were determined recombinant cell cultures expressing hERG channel, QT-prolonging effect assessed 5 clinical studies (80...
The prevalence of positive skin prick tests (SPT) for common allergens and symptoms allergic rhinoconjunctivitis or asthma was investigated in Umeå northern Sweden 1987. Skin with 10 a questionnaire were used to examine 1112 teenagers. All subjects test interviewed, they further by serum specific IgE test, ventilatory lung function physical examination. At least one 43% the subjects. Ninety-three percent had at three most allergens: cat, timothy grass, birch. current 17%, 2.8%, (both...