A5029043530- Cancer, Hypoxia, and Metabolism
- Blood properties and coagulation
- Amino Acid Enzymes and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Erythropoietin and Anemia Treatment
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Tendon Structure and Treatment
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Erythrocyte Function and Pathophysiology
- Cancer-related Molecular Pathways
University of Pennsylvania
2022-2025
Cancer Research Institute
2022
University of Maryland, Baltimore
2016-2021
University of Maryland, Baltimore County
2018
Abstract Glucose metabolism is commonly dysregulated in cancer and other pathological contexts. Fructose-1, 6-bisphosphatase (FBP) a key rate-limiting gluconeogenic enzyme that converts fructose-1, 6-bisphosphate to fructose-6-phosphate, which produces glucose glycogen from noncarbohydrate substrates. Two FBP isoforms, FBP1 FBP2, are differentially expressed human tissues. the primary organs (liver kidney) maintain blood levels under fasting conditions. In contrast, FBP2 expression primarily...
Serine biosynthesis uses 3‐phosphoglycerate, an intermediate of glycolysis, to catalyze the first reaction by phosphoglycerate dehydrogenase (PHGDH). This produces 3‐phosphohydroxypyruvate, which eventually becomes serine through two additional steps. Upregulation has been characterized as a hallmark cancer cell metabolism, is essential metabolite that provides precursors for various building blocks supporting growth and proliferation. We hypothesize enzymes involved in may associate with...