A5039648153- Salmonella and Campylobacter epidemiology
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- Viral gastroenteritis research and epidemiology
- Renal and related cancers
- Geometric Analysis and Curvature Flows
- Vibrio bacteria research studies
- Escherichia coli research studies
- interferon and immune responses
- Trace Elements in Health
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Geometric and Algebraic Topology
- Viral Infectious Diseases and Gene Expression in Insects
- Immunotherapy and Immune Responses
- Fish Biology and Ecology Studies
- Geometry and complex manifolds
- CAR-T cell therapy research
- Immune cells in cancer
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
The University of Melbourne
2020-2024
Peter Doherty Institute
2020-2024
University of Bonn
2023
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
2015
University of Münster
2006
Whereas CD4 + T cells conventionally mediate antitumor immunity by providing help to CD8 cells, recent clinical studies have implied an important role for cytotoxic in cancer immunity. Using orthotopic melanoma model, we provide a detailed account of antitumoral cell responses and their regulation major histocompatibility complex class II (MHC II) the skin. Intravital imaging revealed prominent interactions with tumor debris-laden MHC host antigen-presenting that accumulated around nests,...
Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during Salmonella infection, we infected mice macrophages deficient for diverse combinations caspases-1, -11, -12, -8 receptor interacting serine/threonine kinase 3 (RIPK3). Loss caspase-8-driven apoptosis, or necroptosis had minor impact on control. However, combined deficiency these pathways caused loss bacterial control in their macrophages,...
Naïve CD8 + T cells need to undergo a complex and coordinated differentiation program gain the capacity control virus infections. This not only involves acquisition of effector functions, but also regulates development subset into long-lived protective memory cells. Microbiota-derived metabolites have recently gained interest for their influence on cells, much remains unclear about role in cell differentiation. In this study, we investigated G protein-coupled receptors (GPR)41 GPR43 that can...
Acute kidney injury in mammals, which is caused by cardiovascular diseases or the administration of antibiotics with nephrotoxic side-effects a life-threatening disease, since loss nephrons irreversible mammals. In contrast, fish are able to generate new even adulthood and thus provide good model study renal tubular regeneration.Here, we investigated early response after gentamicin-induced injury, using short-lived killifish Nothobranchius furzeri. A set microRNAs was differentially...
CXCL9 expression is a strong predictor of response to immune checkpoint blockade therapy. Accordingly, we sought develop therapeutic strategies enhance the and augment antitumor immunity. To perform whole-genome CRISPR-Cas9 screening for regulators expression, CXCL9-GFP reporter line generated using CRISPR knockin strategy. This approach finds that IRF1 limits in both tumor cells primary myeloid through induction SOCS1, which subsequently STAT1 signaling. Thus, identify subset...
While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection mediated by CD4 + T cells, identifying circulating protective cells has proved very difficult, inhibiting steps to identify key antigen specificities. Exploiting a mouse model of vaccination, we show that the spleens C57BL/6 mice vaccinated with live-attenuated serovar Typhimurium ( S . Typhimurium) strains carried pool IFN-γ could adoptively transfer protection, but only...