A5063207919- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Pancreatic function and diabetes
- Biochemical Analysis and Sensing Techniques
- Diet, Metabolism, and Disease
- Receptor Mechanisms and Signaling
University of Copenhagen
2019-2023
Novo Nordisk Foundation
2019-2020
Binding of ghrelin to its receptor, growth hormone secretagogue receptor (GHSR), stimulates GH release, induces eating, and increases blood glucose. These processes may also be influenced by constitutive (ghrelin-independent) GHSR activity, as suggested findings in short people with naturally occurring GHSR-A204E mutations reduced food intake glucose rodents administered inverse agonists, both which impair activity. In this study, we aimed more fully determine the physiologic relevance We...
Abstract Context The mechanisms underlying Roux-en-Y gastric bypass (RYGB) surgery-induced weight loss and the immediate postoperative beneficial metabolic effects associated with operation remain uncertain. Enteroendocrine cell (EEC) secretory function has been proposed as a key factor in marked benefits from RYGB surgery. Objective To identify novel gut-derived peptides therapeutic potential obesity and/or diabetes by profiling EEC-specific molecular changes obese patients following...
Preclinical and clinical studies have identified the ghrelin receptor (growth hormone secretagogue 1a; GHSR1a) as a potential target for treating alcohol use disorder. A recent Phase 1a trial of GHSR1a antagonist/inverse agonist, PF-5190457, in individuals with heavy drinking, previously undetected major hydroxy metabolite namely PF-6870961. Here, we further characterized PF-6870961 by screening off-target interactions high throughput screen determined its <i>in vitro</i> pharmacodynamic...
Abstract Dopamine‐producing tyrosine hydroxylase ( TH ) neurones in the hypothalamic arcuate nucleus ARC have recently been shown to be involved ghrelin signalling and body weight homeostasis. In present study, we investigate role of intracellular regulator RhoA response peripheral hormones. Diet‐induced obesity was found associated with increased phosphorylation , indicating obesity‐associated activity neurones. Mice which specifically knocked out ‐RhoA −/− mice) were more sensitive...