A5058627780- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Sex work and related issues
- Immune Cell Function and Interaction
- Hepatitis C virus research
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Impact and Responses
- Reproductive tract infections research
- Adolescent Sexual and Reproductive Health
- Syphilis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Toxic Organic Pollutants Impact
- Cytomegalovirus and herpesvirus research
- Effects and risks of endocrine disrupting chemicals
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Plant Virus Research Studies
- Carcinogens and Genotoxicity Assessment
- Pneumocystis jirovecii pneumonia detection and treatment
Lund University
2016-2025
Skåne University Hospital
2016-2025
Collaborative Research Group
2024
GTx (United States)
2009
Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection.Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected HIV and 2. LPS concentration also CD4 + T cell count viral load independently type.Furthermore, was found be concomitant defective innate mitogen responsiveness.We suggest may contribute loss...
Progressive immune dysfunction and the acquired immunodeficiency syndrome (AIDS) develop in most persons with untreated infection human virus type 1 (HIV-1) but only approximately 20 to 30% of infected HIV 2 (HIV-2); among both types, natural history disease progression is poorly understood.We analyzed data from 223 participants who were HIV-1 after enrollment (with either alone or HIV-2 infection) a cohort long follow-up duration (approximately years), according whether occurred first, time...
HIV-1 is one of the fastest evolving pathogens, and distinguished by geographic genetic variants that have been classified into different subtypes circulating recombinant forms (CRFs). Early in infection primary coreceptor CCR5, but during disease course CXCR4-using populations may emerge. This has correlated with accelerated progression subtype B. Basic knowledge tropism important due to recent introduction antagonists antiretroviral therapy, subtype-specific differences regarding how...
The HIV-1 epidemic in West Africa has been dominated by subtype A and the recombinant form CRF02_AG. Little is known about origins evolutionary history of this region. We employed Maximum likelihood Bayesian methods combination with temporal spatial information to reconstruct distribution, demographic migration patterns over time Guinea-Bissau, Africa. found that CRF02_AG subsubtype A3 were dominant forms Guinea-Bissau they introduced into country on at least six different occasions between...
To study prevalence and incidence of HIV-1 HIV-2 between 1990 2007 to examine impact the civil war in 1998-1999. We also wanted investigate possible interaction HIV-2.Open prospective cohort 4592 police officers Guinea-Bissau, West Africa.Analysis divided 2-3 years time strata.HIV-1 (including HIV-1/HIV-2 dual reactivity) increased gradually from 0.6 3.6% before was 9.5% first serosurvey after war. more than doubled during shortly war, 0.50 1.22 per 100 person-years. Both decreased following...
Background. Antimicrobial stewardship programs are increasingly implemented in hospital care. They aim to simultaneously optimize outcomes for individual patients with infections and reduce financial health-associated costs of overuse antibiotics. Few studies have examined the effects antimicrobial settings low proportions resistance, such as Sweden. Methods. An program was introduced during 5 months 2013 a department internal medicine southern The intervention consisted audits twice weekly...
The Swedish InfCareHIV cohort was established in 2003 to ensure equal and effective care of people living with HIV (PLHIV) enable long-term follow-up. functions equally as a decision support system quality registry, ensuring up-to-date data reported real time.InfCareHIV includes on >99% all diagnosed Sweden up now 13 029 have been included the cohort. HIV-related biomarkers antiretroviral therapies (ART) also demographics, patient-reported outcome measures experience measures.Sweden 2015...
HIV-2 has a lower pathogenicity and transmission rate than HIV-1. Neutralizing antibodies could be contributing to these observations. Here we explored side by the potency breadth of intratype intertype neutralizing activity (NAc) in plasma 20 HIV-1-, HIV-2-, 11 dually HIV-1/2 (HIV-D)-seropositive individuals from Guinea-Bissau, West Africa. Panels primary isolates, five HIV-1 were tested plaque reduction assay using U87.CD4-CCR5 cells as targets. Intratype NAc was found considerably more...
Ineffective antimicrobial therapy of Pseudomonas aeruginosa bacteraemia increases mortality. Recent studies have proposed the use combination composed a beta-lactam with either ciprofloxacin or tobramycin. To determine if correlates to lower mortality and is superior compared monotherapy, we investigated effect treatment regimens on 30-day in cohort bacteraemia. All cases P. (n = 292) southwest Skåne County, Sweden (years 2005–2010, adult population 361,112) whole county (2011–2012, 966,130)...
Background. Human immunodeficiency virus type 1 (HIV-1) is divided into subtypes and circulating recombinant forms (CRFs) but the impact of subtype/CRF on disease progression not fully understood.
The aim of the study was to investigate prevalence faecal carriage extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae among residents living in nursing homes and compare it with a corresponding group elderly people their own homes.A total 160 persons participated between February April 2014, 91 were (n = 10) remaining 69 homes. In addition performing samples, all participants answered standardized questionnaire regarding known risk factors for ESBL-carriage.There no...
To compare survival times of HIV-1 single and HIV-2 dual-infected individuals.Prospective open cohort study.We analysed data from 259 HIV-1-seroincident cases (either or dual-infected) a with long follow-up (~20 years) in order to study the influence type infection on mortality. Sex age at date was controlled for Cox proportional-hazards model.Dual-infected individuals had 42% longer time death compared single-infected individuals, adjusting asymmetries between groups. Dual-infected an...
Background Immunosuppressed patients are particularly vulnerable to severe infection from the acute respiratory syndrome coronavirus 2 (SARS-CoV-2), risking prolonged viremia and symptom duration. In this study we describe clinical virological treatment outcomes in a heterogeneous group of with immunosuppression due various causes suffering COVID-19 infection, who were all treated convalescent plasma (CCP) along standard treatment.Methods We performed an observational, retrospective case...
Abstract An additional upsurge in bacterial STIs has been observed Sweden following HIV pre-exposure prophylaxis (PrEP) implementation. From a prevention perspective, it is of relevance to optimize testing strategies within PrEP programmes identify those most at risk. open retrospective longitudinal observational cohort study was performed three STI clinics Uppsala, Gothenburg, and Malmö. A questionnaire journal data regarding were collected from sample 199 MSM enrolled the providing...
Abstract Background The lung injury in COVID-19 is characterized by neutrophil invasion and the release of extracellular traps (NETs). An aberrant NET formation may induce local inflammation increase sputum viscosity. Inhalation DNase I (dornase alfa) a treatment option that degrades NETs airways. Previous case series have indicated positive clinical effects inhaled dornase alfa. Methods Patients admitted to hospital with acute hypoxia (oxygen saturation <90%) were randomly assigned...
Sentinel surveys in Bissau, the capital of Guinea-Bissau, have shown low prevalence HIV-1 but high HIV-2 before 1998. Guinea-Bissau experienced a civil war 1998-1999. To examine specifically trends HIV from antenatal 1987-2004, and whether 1998-1999 could an effect on levels after conflict.Since 1987, anonymous testing delivering women has been performed at maternity clinic, Simão Mendes National Hospital, as part national sentinel surveillance programme. Consecutive sampling was for...
The objective was to examine the prevalence of HIV-1, HIV-2 and 10 other sexually transmitted infections (STIs), explore relationship between HIV those STIs in women attending two sexual health clinics Bissau, Guinea-Bissau. In all, 711 with urogenital problems were included. Clinical examination performed HIV-2, human T-cell lymphotropic virus (HTLV)-1, HTLV-2 syphilis diagnosed by serology. Trichomonas vaginalis examined using wet mount microscopy. Cervical samples (and swabs from visible...
Abstract Background The diagnosis of syphilis is most frequently dependent on antibody detection with serological assays. Assays for both treponemal and non‐treponemal antibodies are needed to provide a sensitive specific diagnosis. For decades, first screening has been done assays, followed by treponemal. However, in recent years, following laboratory automation, the reverse sequence algorithms have developed, using assay as initial test. Objective To evaluate assays antibodies, use...
All-cause and AIDS-mortality in Europe has been decreasing between 1996 2020. However, regional differences as well their drivers remain unclear. This study investigates mortality drivers, including usage of response to antiretroviral therapy (ART) active tuberculosis (TB), among people with HIV across Europe.
Plasmodium falciparum transmission has decreased significantly in Zambia the last decade. The malaria is influenced by environmental variables. Incorporation of variables models likely improves model fit and predicts probable trends disease. This work based on hypothesis that remotely-sensed factors, including nocturnal dew point, are associated with sustain foci during low season Southern Province Zambia. Thirty-eight rural health centres Province, were divided into three zones patterns....