A5067942768- Renal Diseases and Glomerulopathies
- Complement system in diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Chronic Kidney Disease and Diabetes
- Digestive system and related health
- Mast cells and histamine
- Mental Health Research Topics
- Bone and Joint Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 Impact on Reproduction
- Treatment of Major Depression
- Bone Metabolism and Diseases
- T-cell and B-cell Immunology
- Polyamine Metabolism and Applications
- Immune Cell Function and Interaction
- Child and Adolescent Psychosocial and Emotional Development
- Bone health and treatments
- Platelet Disorders and Treatments
- COVID-19 epidemiological studies
Wuhan Third Hospital
2025
Peking University First Hospital
2021-2024
Peking University
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Ministry of Education of the People's Republic of China
2022-2024
King University
2024
IntroductionTelitacicept, a transmembrane activator and cyclophilin ligand (CAML) interactor (TACI) fusion protein targeting B cell activating factor (BAFF) proliferation-inducing (APRIL), has proven efficacy in treating Immunoglobulin A (IgA) nephropathy. However, serum biomarkers that could predict the clinical response during treatment remain unclear.MethodsPlasma samples from 24 participants Phase 2 trial were collected at baseline after 4, 12, weeks, 8 placebo group, 9 160 mg 7 240...
Diabetes is a common disease contributing to osteoporosis. Epimedin B (EB), major ingredient of Herba Epimedii, has been found be effective in preventing osteoporosis mice. However, the potential EB ameliorate diabetic (DOP) remains elusive. In this study, our goal investigate functions and underlying mechanisms progression DOP. A DOP rat model was established via high-fat diet combined with intraperitoneal injection streptozotocin (STZ). rats were daily administered or vehicle intragastric...
The TESTING trial demonstrated that corticosteroids reduce the risk of kidney failure in patients with IgA nephropathy (IgAN) but increase serious adverse events. Reliable noninvasive biomarkers are needed to identify who would benefit most from corticosteroid therapy. Previous studies suggest glomerular macrophage infiltration is associated response immunosuppressive therapy IgAN and urinary soluble CD163 ([u-sCD163], a marker alternatively activated macrophages [M2]c macrophage) correlated...
IgA nephropathy (IgAN) is the most commonly reported glomerulonephritis associated with COVID-19 vaccine.1Stevens K.I. Frangou E. Shin J.I. et al.Perspective on vaccination in patients immune-mediated kidney diseases: consensus statements from ERA-IWG and EUVAS.Nephrol Dial Transplant. Published online March 4, 2022; https://doi.org/10.1093/ndt/gfac052Crossref PubMed Scopus (2) Google Scholar,2Klomjit N. Alexander M.P. Fervenza F.C. al.COVID-19 glomerulonephritis.Kidney Int Rep. 2021; 6:...
Key Points We generated a transgenic mouse model expressing the human IgA1 heavy chain, which has hinge region with rich O -linked glycosylation. After inflammatory stimulation, showed elevated galactose-deficient levels in serum. Coupled complement H factor mutant, mice exhibited glomerular lesions, associated hematuria and albuminuria like IgA nephropathy. Background nephropathy is most common primary glomerulonephritis worldwide, there emerging evidence linking (Gd-IgA1) to pathogenesis...
Abstract Patients with chronic kidney disease (CKD) are at higher risk for coronavirus 2019 (COVID-19)-related morbidity and mortality. However, a significant portion of CKD patients showed hesitation toward vaccination in telephone survey our center. Yet no serial data available on humoral response CKD, especially those immunosuppression. We conducted pilot, prospective study to the safety inactivated SARS-CoV-2 vaccine receiving 2-dose immunization vaccine. found neutralizing antibody...