A5080444121- RNA modifications and cancer
- Cancer-related gene regulation
- Acute Lymphoblastic Leukemia research
- Cell death mechanisms and regulation
- Head and Neck Cancer Studies
- PARP inhibition in cancer therapy
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Cancer-related Molecular Pathways
Centre Hospitalier de l’Université de Montréal
2022-2024
Childhood acute lymphoblastic leukemia (cALL) survivors suffer early-onset chronic diseases classically associated with aging. Normal aging is accompanied by organ dysfunctions, including immunological ones. We hypothesize that thymic immunosenescence occurs in cALL and its severity may correlate diseases. The PETALE study a survivor cohort an extensive cardiovascular metabolic evaluation. biomarker, signal joint T-cell receptor excision circles (TREC), was evaluated highly correlated age...
ABSTRACT High-grade serous ovarian cancer (HGSOC) remains the most lethal gynecological malignancy in North American women. At a cellular level, current first-line chemotherapies cause DNA-damage and activate DNA damage response signalling cascade. Here we explore role of 53BP1, central mediator response, HGSOC chemotherapy outcomes. Tissue 53BP1 protein levels were quantified two independent cohorts, COEUR validation cohort (n = 173) CHUM 56). Univariate multivariate analyses showed that...