A5024127357- Childhood Cancer Survivors' Quality of Life
- Nutrition and Health in Aging
- Acute Lymphoblastic Leukemia research
- Cholesterol and Lipid Metabolism
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Family Support in Illness
- Chemotherapy-induced cardiotoxicity and mitigation
- Adolescent and Pediatric Healthcare
- Diet and metabolism studies
- Pancreatic function and diabetes
- Child Nutrition and Water Access
- Digestive system and related health
- Cancer, Lipids, and Metabolism
- Pancreatitis Pathology and Treatment
- Fatty Acid Research and Health
- Palliative Care and End-of-Life Issues
- Family and Disability Support Research
- Child Nutrition and Feeding Issues
- Peroxisome Proliferator-Activated Receptors
- Connective tissue disorders research
- Scoliosis diagnosis and treatment
- Statistical Methods and Inference
- Metabolism, Diabetes, and Cancer
- Advanced Causal Inference Techniques
Centre Hospitalier Universitaire Sainte-Justine
2016-2025
Université de Montréal
2016-2025
McGill University
2010-2025
Toronto Metropolitan University
2025
Université du Québec à Chicoutimi
2025
Centre Hospitalier de l’Université de Montréal
2024
Université Laval
2017-2022
McGill University Health Centre
2009-2019
Centre hospitalier universitaire de Québec
2011
Université Claude Bernard Lyon 1
2011
Recent studies have documented the presence of Niemann-Pick C1-Like 1 (NPC1L1) in small intestine and its capacity to transport cholesterol mice rats. The current investigation was undertaken explore localization function NPC1L1 human enterocytes. Cell fractionation experiments revealed an association with apical membrane enterocyte jejunum. Signal also detected lysosomes, endosomes, mitochondria. Confirmation cellular distribution obtained by immunocytochemistry. Knockdown caused a decline...
Cranberry fruit has been reported to have high antioxidant effectiveness that is potentially linked its richness in diversified polyphenolic content. The aim of the present study was determine role cranberry fractions oxidative stress (OxS), inflammation and mitochondrial functions using intestinal Caco-2/15 cells. combination HPLC UltraPerformance LC®-tandem quadrupole (UPLC-TQD) techniques allowed us characterize profile low, medium molecular mass compounds extracts. fraction enriched with...
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Contributory factors such as inflammation and oxidative stress, in response to drug therapies, may induce premature aging cellular senescence with a severe impact on cardiometabolic health. Premature immunoaging through can lead lower thymic output of T-cell lymphocytes translated into circulating receptor excision circles (TRECs). We hypothesized TRECs levels are associated diet quality impacted by inflammatory status...
Abstract Background Childhood cancer survivorship issues represent an established public health challenge. Most late adverse effects (LAEs) have been demonstrated to be time and treatment dependent. The PETALE study is a multidisciplinary research project aiming comprehensively characterize LAEs identify associated predictive biomarkers in childhood acute lymphoblastic leukemia (cALL) survivors. Methods cALL survivors treated at Sainte‐Justine University Health Center with Dana‐Farber Cancer...
Short-chain fatty acids (SCFAs) are potent modulators of the growth, function, and differentiation intestinal epithelia. In addition, high-fiber diets may protect against development atherosclerosis because their cholesterol-lowering effects due, in large part, to SCFA production, liver sterol metabolism, bile acid excretion. Although small gut plays a major role dietary fat transport contributes substantially plasma cholesterol lipoprotein homeostasis, impact SCFAs on lipid handling remains...
Survivors of acute lymphoblastic leukemia (ALL), the most common cancer in children, are at increased risk developing late cardiometabolic conditions. However, mechanisms not fully understood. This study aimed to characterize plasma lipid profile, Apo distribution, and lipoprotein composition 80 childhood ALL survivors compared with 22 healthy controls. Our results show that, despite their young age, 50% displayed dyslipidemia, characterized by triglyceride (TG) LDL-cholesterol, as well...
Abstract Our objectives were to assess the prevalence of cardiometabolic complications in children, adolescents, and young adult survivors childhood acute lymphoblastic leukemia (cALL), identify their predictors risk compared Canadian population. We performed a assessment cALL from PETALE cohort (n = 247, median age at visit 21.7 years). In our group, overweight obesity affected over 70% women. Pre-hypertension hypertension mostly common men, both adults (20%) children (19%). Prediabetes was...
Abstract Transport mechanisms, whereby alimentary lipids are digested and packaged into small emulsion particles that enter intestinal cells to be translocated the plasma in form of chylomicrons, impaired cystic fibrosis. The purpose this paper is focus on defects related intraluminal intracellular events life-limiting genetic disorder. Specific evidence presented highlight relationship between fat malabsorption essential fatty acid deficiency commonly found patients with fibrosis often...
Understanding the mechanisms involved in oxidative stress-induced foam cell formation is of fundamental importance for atherosclerosis. Our aim was to characterize effects stress on key receptors macrophage cholesterol homeostasis, nuclear transcription factors PPAR and LXR regulating their expression, handling.The incubation macrophages derived from human monocyte line THP-1 with iron (100 microm)/ascorbate (1000 microm) a period 4 h induced strong peroxidation, as demonstrated by elevation...
Hepatocyte nuclear factor 4α (HNF4α) is a transcription mainly expressed in the liver, intestine, kidney, and pancreas. Many of its hepatic pancreatic functions have been described, but limited information available on role gastrointestinal tract. The objectives this study were to evaluate anti-inflammatory antioxidant HNF4α as well implication intestinal lipid transport metabolism. To end, HNF4A gene was knocked down by transfecting Caco-2 cells with pGFP-V-RS lentiviral vector containing...
Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of therapy. A regular practice physical activity and a good cardiorespiratory fitness have potential to reduce risk disease improve quality life. The aim this study was evaluate in cohort ALL survivors, association between or respect guidelines major long-term health outcomes.In total, 247 underwent cardiopulmonary exercise test, completed questionnaire...
Introduction The gastrointestinal tract is frequently exposed to noxious stimuli that may cause oxidative stress, inflammation and injury. Intraluminal pro-oxidants from ingested nutrients especially iron salts ascorbic acid consumed together, can lead catalytic formation of oxygen-derived free radicals ultimately overwhelm the cellular antioxidant defense cell damage. Hypothesis Since mechanisms remain sketchy, efforts have been exerted evaluate role epigenetics in modulating components...
SAR1b plays a significant role in the assembly, organization, and function of coat protein complex II, critical for transport proteins from endoplasmic reticulum to Golgi. Recently, mutations SARA2 have been associated with lipid absorption disorders. However, functional studies on Sar1b-mediated synthesis pathways lipoprotein packaging not performed.Sar1b was overexpressed Caco-2/15 cells resulted significantly augmented triacylglycerol, cholesteryl ester, phospholipid esterification...
This study aims to describe the feasibility of a nutritional intervention that promotes healthy eating habits early after cancer pediatric diagnosis in patients and their parents. Participants were recruited 4 12 weeks as part VIE study. The one-year included an initial evaluation 6 follow-up visits every 2 months with registered dietician. assessment rates retention, participation, attendance, completion measures, participants' engagement. A preliminary intervention's impact on dietary...
Childhood acute lymphoblastic leukemia (cALL) survivors suffer early-onset chronic diseases classically associated with aging. Normal aging is accompanied by organ dysfunctions, including immunological ones. We hypothesize that thymic immunosenescence occurs in cALL and its severity may correlate diseases. The PETALE study a survivor cohort an extensive cardiovascular metabolic evaluation. biomarker, signal joint T-cell receptor excision circles (TREC), was evaluated highly correlated age...
Background/Objectives: Pediatric cancer survivors are at greater risk of cardiometabolic complications than their peers. This study evaluates the preliminary impact VIE (Valorization, Implication, Education) intervention, which integrates nutrition, physical activity, and psychological support, on dietary intake health among children adolescents during treatment. Methods: comparative includes pediatric patients recruited to either intervention group or a control receiving standard care....
Metabolic syndrome (MetS) constitutes a spectrum of interconnected conditions comprising obesity, dyslipidemia, hypertension, and insulin resistance (IR). While singular, all-encompassing treatment for MetS remains elusive, an integrative approach involving tailored lifestyle modifications emerging functional food therapies holds promise in preventing its multifaceted manifestations. Our main objective was to scrutinize the efficacy cranberry proanthocyanidins (PAC, 200 mg/kg/day 12 weeks)...
Paraoxonase (PON) family members seem central to a wide variety of human illnesses, but appreciation their antioxidative function in the gastrointestinal tract is its infancy. The major objective present work highlight role ubiquitously expressed PON2 small intestine. With use pLKO lentiviral vector containing short hairpin RNA (shRNA) lentivirus, expression was knocked down intestinal Caco-2/15 cells, where status, lipid peroxidation, and degree inflammation were evaluated. As consequence...