A5010481627- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Cancer-related cognitive impairment studies
- Epigenetics and DNA Methylation
- Family Support in Illness
- Genetics and Neurodevelopmental Disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Nutrition and Health in Aging
- RNA modifications and cancer
- Neurogenetic and Muscular Disorders Research
- Genomics and Chromatin Dynamics
- Family and Disability Support Research
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Advanced Causal Inference Techniques
- Statistical Methods and Inference
- Adolescent and Pediatric Healthcare
- Antifungal resistance and susceptibility
- Children's Physical and Motor Development
- Heart Failure Treatment and Management
- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- Fungal and yeast genetics research
- Cancer, Lipids, and Metabolism
- Genomics and Rare Diseases
National Research Council Canada
2018-2025
Centre Hospitalier Universitaire Sainte-Justine
2006-2023
Inserm
2021
Université Paris Cité
2021
Sorbonne Université
2021
Université de Montréal
2008-2020
RELX Group (Netherlands)
2018
Montreal Heart Institute
2017
Schlumberger (Ireland)
2017
Centre Hospitalier Universitaire de Reims
2017
In this study, we show the high frequency of spontaneous γδ T-cell leukemia (T-ALL) occurrence in mice with biallelic deletion enhancer zeste homolog 2 ( Ezh2 ). Tumor cells little residual H3K27 trimethylation marks compared controls. EZH2 is a component PRC2 Polycomb group protein complex, which associated DNA methyltransferases. Using next-generation sequencing, identify alteration gene expression levels and acquired mutations PRC2-associated genes DNMT3A JARID2 ) human adult T-ALL....
Histone deacetylase Rpd3 is part of two distinct complexes: the large (Rpd3L) and small (Rpd3S) complexes. While Rpd3L targets specific promoters for gene repression, Rpd3S recruited to ORFs deacetylate histones in wake RNA polymerase II, prevent cryptic initiation within genes. Methylation histone H3 at lysine 36 by Set2 methyltransferase thought mediate recruitment Rpd3S. Here, we confirm ChIP–Chip that binds active ORFs. Surprisingly, however, not all genes, its Set2-independent. However,...
In Saccharomyces cerevisiae, zinc cluster protein Pdr1 can form homodimers as well heterodimers with Pdr3 and Stb5, suggesting that different combinations of these proteins may regulate the expression genes. To gain insight into interplay among regulators, we performed genome-wide location analysis (chromatin immunoprecipitation hybridization to DNA microarrays) gene profiling. Unexpectedly, observed Stb5 shares only a few target genes or in rich medium. Interestingly, upon oxidative stress,...
ABSTRACT Upc2p, a transcription factor of the zinc cluster family, is an important regulator sterol biosynthesis and azole drug resistance in Candida albicans . To better understand Upc2p function C. , we used genomewide location profiling to identify transcriptional targets vivo. A triple hemagglutinin epitope, introduced at C terminus conferred gain-of-function effect on fusion protein. Location identified 202 bound promoters ( P < 0.05). Overrepresented functional groups genes whose...
Abstract Background Childhood cancer survivorship issues represent an established public health challenge. Most late adverse effects (LAEs) have been demonstrated to be time and treatment dependent. The PETALE study is a multidisciplinary research project aiming comprehensively characterize LAEs identify associated predictive biomarkers in childhood acute lymphoblastic leukemia (cALL) survivors. Methods cALL survivors treated at Sainte‐Justine University Health Center with Dana‐Farber Cancer...
Freezing tolerance in plants is a complex trait that occurs many plant species during growth at low, nonfreezing temperatures, process known as cold acclimation. This regulated by multigenic system expressing broad variation the degree of freezing among wheat cultivars. Microarray analysis powerful and rapid approach to gene discovery. In such wheat, for which large scale mutant screening transgenic studies are not currently practical, genotype comparison this methodology represents an...
Survivors of acute lymphoblastic leukemia (ALL), the most common cancer in children, are at increased risk developing late cardiometabolic conditions. However, mechanisms not fully understood. This study aimed to characterize plasma lipid profile, Apo distribution, and lipoprotein composition 80 childhood ALL survivors compared with 22 healthy controls. Our results show that, despite their young age, 50% displayed dyslipidemia, characterized by triglyceride (TG) LDL-cholesterol, as well...
Abstract Our objectives were to assess the prevalence of cardiometabolic complications in children, adolescents, and young adult survivors childhood acute lymphoblastic leukemia (cALL), identify their predictors risk compared Canadian population. We performed a assessment cALL from PETALE cohort (n = 247, median age at visit 21.7 years). In our group, overweight obesity affected over 70% women. Pre-hypertension hypertension mostly common men, both adults (20%) children (19%). Prediabetes was...
In Saccharomyces cerevisiae, RDS2 encodes a zinc cluster transcription factor with unknown function. Here, we unravel key function of Rds2 in gluconeogenesis using chromatin immunoprecipitation-chip technology. While observed that binds to only few promoters glucose-containing medium, it many additional genes when the medium is shifted ethanol, nonfermentable carbon source. Interestingly, these are involved gluconeogenesis, tricarboxylic acid cycle, and glyoxylate cycle. Importantly, show...
Recognition of histone marks by reader modules is thought to be at the heart epigenetic mechanisms. These protein domains are considered function targeting regulators chromosomal loci carrying specific modifications. This important for proper gene regulation as well propagation information. The NuA4 acetyltransferase complex contains two these modules, an H3K4me3-specific plant homeodomain (PHD) within Yng2 subunit and H3K36me2/3-specific chromodomain in Eaf3 subunit. While each domain...
Childhood acute lymphoblastic leukemia (cALL) is the most common pediatric cancer and, despite an 85% cure rate, still represents a major cause of disease-related death in children. Recent studies have implicated long non-coding RNAs (lncRNAs) cALL etiology, progression, and treatment response. However, barring some exceptions little known about functional impact lncRNAs on biology, which limits their potential as therapeutic targets. We wanted to investigate role identified specifically...
Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of therapy. A regular practice physical activity and a good cardiorespiratory fitness have potential to reduce risk disease improve quality life. The aim this study was evaluate in cohort ALL survivors, association between or respect guidelines major long-term health outcomes.In total, 247 underwent cardiopulmonary exercise test, completed questionnaire...
Abstract Background Systematic assessment of emotional distress is recommended in after care. Yet, it unclear if parent report may be used as a proxy child report. The aim this study was to assess agreements and differences explore possible moderators disagreement between ratings. Methods Sixty‐two young survivors treated for acute lymphoblastic leukemia (9–18 years) both parents responded the Beck Youth Inventory (anxiety depression) rating scale on child's status. Parents completed Brief...
Abstract Background Recent research has suggested that long‐term pediatric cancer survivors were at risk of important physical and psychological morbidities. To date, we do not know to what extent functional health status contributes which domains are most important. The aim this study was systematically explore domain could explain anxiety, depression, distress symptoms. Procedure We used data available for 105 adolescents 182 adults successfully treated childhood acute lymphoblastic...
// Romain Gioia 1 , Simon Drouin Manon Ouimet Maxime Caron Pascal St-Onge Chantal Richer and Daniel Sinnett 1, 2 Division of Hematology-Oncology, Research Center, Sainte-Justine University Health Montreal, QC, Canada Department Pediatrics, Faculty Medicine, Correspondence to: Sinnett, email: daniel.sinnett@umontreal.ca Keywords: long non-coding RNA, acute lymphoblastic leukemia, DNA damage response, treatment resistance, apoptosis Received: February 24, 2017 Accepted: August 19, Published:...
Pre-B cell childhood acute lymphoblastic leukemia (pre-B cALL) is a heterogeneous disease involving many subtypes typically stratified using combination of cytogenetic and molecular-based assays. These methods, although widely used, rely on the presence known chromosomal translocations, which limiting factor. There therefore need for robust, sensitive, specific molecular biomarkers unaffected by such limitations that would allow better risk stratification consequently clinical outcome. In...
Introduction: As the survival rate of childhood acute lymphoblastic leukemia (ALL) continues to improve, physical deconditioning is becoming an increasingly common problem in survivors. The aim this study was compare cardiorespiratory fitness and activity levels survivors control participants. Methods: A total 221 ALL (114 males 107 females), diagnosed between 1987 2010 treated according Dana Farber Cancer Institute-ALL 87-01 05-01 protocols at Sainte-Justine University Health Center...
The most common rearrangement in childhood precursor B-cell acute lymphoblastic leukemia is the t(12;21)(p13;q22) translocation resulting ETV6-AML1 fusion gene. A frequent concomitant event loss of residual ETV6 allele suggesting a critical role for transcriptional repressor etiology this cancer. However, precise mechanism through which functional contributes to disease pathogenesis still unclear. To investigate impact on network and identify new targets ETV6, we used whole transcriptome...