A5080371446- Fatty Acid Research and Health
- COVID-19 and healthcare impacts
- Seaweed-derived Bioactive Compounds
- COVID-19 Clinical Research Studies
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Diagnosis and treatment of tuberculosis
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Anorectal Disease Treatments and Outcomes
- Macrophage Migration Inhibitory Factor
- Tryptophan and brain disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Anesthesia and Sedative Agents
- Ovarian cancer diagnosis and treatment
- Cardiac Fibrosis and Remodeling
- Parasites and Host Interactions
- Hemodynamic Monitoring and Therapy
- ATP Synthase and ATPases Research
- Natural product bioactivities and synthesis
Brigham and Women's Hospital
2015-2024
Harvard University
2015-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2023
Vita-Salute San Raffaele University
2020-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Abstract Maresin 1 (MaR1) is an immunoresolvent that governs resolution of acute inflammation, and its local metabolism in the context infectious inflammation interest. In this study, we investigated MaR1 metabolome exudates bioactions regulating leukocyte responses bacterial infection. Escherichia coli exudates, was temporally regulated with maximal levels at 4 h (2.2 ± 0.4 pg/lavage). these also identified two novel products, their structure elucidation gave 22-hydroxy-MaR1 14-oxo-MaR1....
Abstract Ovarian cancer (OvCa), while accounting for only 3% of all women’s cancer, is the fifth leading cause death among women. One most significant obstacles to successful OvCa treatment chemoresistance. The current lack understanding driving mechanisms underlying chemoresistance hinders development effective therapeutics against this obstacle. Adipocytes are key components microenvironment and have been shown be involved in cell proliferation, however, little known about their impact on...
Significance We recently uncovered a family of macrophage-derived molecules, coined maresin conjugates in tissue regeneration, that regulate the system’s ability to clear bacteria as well repair and regenerate damaged tissues. In present study, we identified enzymes involved formation these potent molecules human macrophages. These were shared with classic cysteinyl leukotrienes, underscoring presence conserved biosynthetic motifs two functionally distinct lipid mediator families. Inhibition...
Background and Purpose Treatment with triglyceride emulsions of docosahexaenoic acid (tri-DHA) protected neonatal mice against hypoxia-ischemia (HI) brain injury. The mechanism this neuroprotection remains unclear. We hypothesized that administration tri-DHA enriches HI-brains DHA/DHA metabolites. This reduces Ca2+-induced mitochondrial membrane permeabilization attenuates Methods 10-day-old C57BL/6J following HI-brain injury received tri-DHA, tri-EPA or vehicle. At 4–5 hours reperfusion,...
Clinical trials have shown that administration of the nematode Trichuris suis can be beneficial in treating various immune disorders. To provide insight into mechanisms by which this worm suppresses inflammatory responses, an active component was purified from T. soluble products (TsSPs) suppress TNF and IL-12 secretion LPS-activated human dendritic cells (DCs). Analysis liquid chromatography tandem mass spectrometry identified compound as prostaglandin (PG)E2. The showed similar properties...
The n-3 polyunsaturated fatty acids act as substrates during the resolution phase of acute inflammation for biosynthesis specialized pro-resolving lipid mediators. One premier example is C22-dihydroxy-polyunsaturated acid protectin D1 (1). human 15-lipoxygenase type I, via stereoselective processes and with docosahexaenoic substrate, enables formation this mediator. Herein, based on results from LC/MS-MS metabololipidomics, support presented apprehended 1 in macrophages occurring...
SPECIALTY GRAND CHALLENGE article Front. Anesthesiol., 25 January 2023Sec. Cardiothoracic Anesthesiology Volume 1 - 2022 | https://doi.org/10.3389/fanes.2022.1115750
Melatonin is a neurohormone well-known as sleep disorder treatment. A few clinical trials have recently pointed out the biological plausibility of utilising melatonin in treatment coronavirus disease 2019 (COVID-19, SARS-CoV-2) patients. wide range activities include anti-inflammatory, antiviral and antioxidant effects. Our meta-analysis aimed to investigate effect on mortality COVID-19 patients with different severity. We searched PubMed, EMBASE, Web Science no language restrictions updated...
Carcinomas of the anal canal are staged according to size and extent disease; however, we propose including a novel ultrasound (US) staging system, based on depth tumor invasion. In this study clinical American Joint Committee Cancer (AJCC) guidelines US classificationss in patients with cancer were compared.To evaluate prognostic role system cancer.The data 48 squamous cells carcinoma, observed at our University Hospital between 2007 2017, who underwent pre-treatment assessment pelvic...
Introduction: After myocardial infarction (MI) self-healing is prominent in mice but not humans. MI-induced innate inflammatory and resolving response unclear left ventricle (LV) healing. Hypothesis: To define response, our aim was to quantitate time-dependent generation of specialized pro-resolving mediators (SPMs) leukocyte trafficking the LV spleen post-MI. Methods: We determined kinetics by flow cytometry quantitated resolution metabolome using mass spectrometry C57BL/6 after permanent...