A5048683375- Parasites and Host Interactions
- Helminth infection and control
- Parasitic Infections and Diagnostics
- Parasite Biology and Host Interactions
- Toxoplasma gondii Research Studies
- Animal Disease Management and Epidemiology
- Parasitic infections in humans and animals
- Microscopic Colitis
- Immune Response and Inflammation
- Inflammatory Bowel Disease
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Advanced Welding Techniques Analysis
- Antimicrobial Peptides and Activities
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Drug Transport and Resistance Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Mycobacterium research and diagnosis
- Multiple Sclerosis Research Studies
- Parasitic Diseases Research and Treatment
- Inflammasome and immune disorders
- Probiotics and Fermented Foods
- Pneumocystis jirovecii pneumonia detection and treatment
University of Copenhagen
2007-2020
West Park Hospital
2009
Hannah Research Foundation
2009
Trichuris suis is a common parasitic helminth of pigs. As with many other parasites, T. ensures its own survival by evading host immune responses, but little known about how this achieved. MicroRNAs (miRNA) have been shown to be involved in various immunological processes post-transcriptional regulation specific genes, and the potential using these molecules as biomarkers disease currently being examined. It has recently that parasites may secrete extracellular structures such exosomes...
Clinical trials have shown that administration of the nematode Trichuris suis can be beneficial in treating various immune disorders. To provide insight into mechanisms by which this worm suppresses inflammatory responses, an active component was purified from T. soluble products (TsSPs) suppress TNF and IL-12 secretion LPS-activated human dendritic cells (DCs). Analysis liquid chromatography tandem mass spectrometry identified compound as prostaglandin (PG)E2. The showed similar properties...
Eggs of the porcine whipworm Trichuris suis are currently explored in human clinical trials as a treatment immune-mediated diseases. In this context, only infective, embryonated eggs, constitute Active Pharmaceutical Ingredient (API). The rodent whipworm, muris is commonly used laboratory model to study biology. eggs (containing fully developed larva) biologically active and will invade large intestinal mucosa host. This aims assess vitro hatching T. various bacterial cultures measure for...
Interactions between dendritic cells (DCs) and environmental, dietary pathogen antigens play a key role in immune homeostasis regulation of inflammation. Dietary polyphenols such as proanthocyanidins (PAC) may reduce inflammation, we therefore hypothesized that PAC suppress lipopolysaccharide (LPS) -induced responses human DCs subsequent T helper type 1 (Th1) -type naive cells. Moreover, proposed that, because are likely to be exposed multiple stimuli, the activity synergise with other...
The population dynamics of Ascaris suum was studied by long-term exposure pigs to infective eggs. were experimentally inoculated with 25 A. eggs/kg/day, and 7, 8, 8 necropsied at weeks 4, 14 postinoculation (PI), respectively. Despite the fact that continuously reinfected, dramatic reductions in numbers liver lesions (white spots) migrating lung larvae observed as a function time. However, even end study, few able complete migration, but these seemed unable mature small intestine. Thus,...
The population dynamics of Trichuris suis in pigs was studied during long-term experimental infections. Twenty-three 10-week-old were inoculated with 5 T. eggs/kg/day. Seven, 8, and 8 necropsied at weeks 4, 14 post-start infection (p.i.), respectively. median numbers worms the colon 538 (min-max: 277-618), 332 (14-1140) 0 (0-4) p.i. respectively, suggesting an increased aggregation time acquisition nearly sterile immunity. serum levels specific antibodies (IgG1, IgG2 IgA) peaked week By IgA...
Abstract The pig whipworm Trichuris suis is important in swine production because of its negative effects on performance and, notably, to some humans with inflammatory bowel disease as a therapeutic agent that modulates inflammation. proximal colon T. -infected pigs exhibited general inflammation around day 21 after inoculation infective eggs transcriptionally characterized by markers type-2 immune activation, inflammation, cellular infiltration, tissue repair enzymes, pathways oxidative...
Summary The humoral immune response induced by Trichuris infections has mostly been described in mouse models and infected humans, but as the immunomodulatory effect of suis, swine whipworm, becomes increasingly documented, need for understanding this specific parasite species grows. In present study we describe changes serum IgG1, IgG2, IgA IgM antibodies to adult T. suis excretory/secretory (E/S) antigens time course a primary infection swine. average levels IgG2 peaked at 9 weeks...
SUMMARY The objective of the present study was to develop an ELISPOT method measure parasite‐specific IL‐4 producing cells during experimental Ascaris suum and Trichuris suis infections in pigs. In many settings it is useful be able changes specifically induced cytokines over time at post‐mRNA level; particular, specific measurement important for studies on nematodes due key function driving Th2 response. Two separate experiments were carried out, one with A. other T. infection which we...
To demonstrate that administration of 7500 Trichuris suis ova [TSO] every second week over 24 weeks would reduce the intestinal inflammation in moderate ulcerative colitis.