A5068009693- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
University of Florida
2019-2023
Allen Institute for Brain Science
2018
Memory requires similar episodes with overlapping features to be represented distinctly, a process that is disrupted in many clinical conditions as well normal aging. Data from humans have linked this ability activity hippocampal CA3 and dentate gyrus (DG). While animal models shown the perirhinal cortex critical for disambiguating stimuli, has not been causally discrimination abilities. The goal of current study was determine how disrupting CA3/DG would impact performance on rodent mnemonic...
Theta oscillations in the primary visual cortex (VC) have been observed during running tasks, but mechanism behind their generation is not well understood. Some studies suggested that theta VC locally generated, while others proposed it volume conducted from hippocampus. The present study aimed to investigate relationship between hippocampal and LFP dynamics. Analysis of power spectral density revealed was similar hippocampus, with lower overall magnitude. As velocity increased, both...
The hippocampal theta rhythm strongly correlates to awake behavior leading theories that it represents a cognitive state of the brain. As has been observed in other regions Papez circuit, theorized activity propagates reentrant manner. These observations complement energy cascade hypothesis which large-amplitude, slow-frequency oscillations reflect propagating across large population neurons. Higher frequency oscillations, such as gamma, are related speed with inhibitory and excitatory...
Abstract Memory requires similar episodes with overlapping features to be represented distinctly, a process that is disrupted in many clinical conditions as well normal aging. Data from humans have linked this ability activity hippocampal CA3 and dentate gyrus (DG). While animal models shown the perirhinal cortex critical for disambiguating stimuli, has not been causally discrimination abilities. The goal of current study was determine how disrupting CA3/DG would impact performance on rodent...
ABSTRACT It is well established that degradation of perforant path fibers associated with age-related cognitive dysfunction and CA3 hyperactivity. Whether this fiber loss triggers a cascade other functional changes within the hippocampus circuit has not been causatively established, however. Thus, current study evaluated effect on neuronal activity in layer II lateral entorhinal cortex (LEC) relation to mnemonic similarity task performance. Expression immediate early gene Arc was quantified...
It is well established that degradation of perforant path fibers associated with age-related cognitive dysfunction and CA3 hyperactivity. Whether this fiber loss triggers a cascade other functional changes within the hippocampus circuit has not been causatively established, however. Thus, current study evaluated effect on neuronal activity in layer II lateral entorhinal cortex (LEC) relation to mnemonic similarity task performance. Expression immediate early gene Arc was quantified rats...