Fibroblast Growth Factor (FGF)-10 promotes the proliferation and survival of murine hepatoblasts during early stages hepatogenesis through a Wnt-β-catenin dependent pathway. To determine mechanism by which this occurs, we expanded primary culture enriched for progenitor markers CD133 CD49f from embryonic day (E) 12.5 fetal liver an established tumor initiating stem cell line Mat1a−/− livers in media conditioned with recombinant (r) FGF10 or rFGF7. FGF Receptor (R) activation resulted...

Prolonged hospitalization and reoperation after free tissue transfer may be associated with certain clinical factors.To determine patient surgical factors length of stay (LOS) following procedures for malignant neoplasm the head neck involving microvascular reconstruction.This was a retrospective review American College Surgeons National Surgical Quality Improvement Program data from 2012 to 2014 using International Classification Diseases, Ninth Revision (ICD-9), codes neoplasms neck....

With oropharyngeal cancer incidence rising globally, largely due to human papillomavirus (HPV), and hypopharyngeal known for poor outcomes, innovative treatments are needed. Transoral robotic surgery (TORS) offers a minimally invasive approach that may improve upon traditional open radiotherapy/chemoradiotherapy (RT/CRT) methods. We conducted literature review included 40 PubMed studies comparing TORS, surgery, RT/CRT squamous cell carcinoma (SCC), focusing on survival rates swallowing...

Objective This study aims to analyze the trends in incidence of human papilloma virus (HPV)-mediated oropharyngeal squamous cell carcinoma (OPSCC) relation geographic rates HPV vaccination United States. Methods The US Cancer Statistics (USCS) database and National Institute's (NCI's) Surveillance, Epidemiology End Results (SEER) program were used for population data collection; Centers Disease Control Prevention's (CDC) Teen Immunization Survey provided data. Incidence HPV-mediated OPSCC...

Social media continues to grow as a relevant information source for the lay public and medical professionals.A search of posts on Facebook Instagram was conducted using hashtag #laryngectomy. Posts were categorized based upon perspective, type, timeframe, topic, tone, popularity.Final analysis included 929 355 posts. Most made by companies (38%) physicians (17%) with (30%) advertisements (22%) being common topics. Patients (40%) largest group authors lifestyle (39%) most topic. Greater than...

Nasal obstruction due to weakening of the nasal sidewall is a very common patient complaint. The conchal cartilage butterfly graft proven technique for correction valve collapse. It allows excellent functional results, and with experience attention technical detail, it may also provide cosmetic results. While this procedure most useful restoring form function in cases secondary rhinoplasty following reduction support structures, we have found be powerful satisfying primary as well. This...

What is the current state of evidence-based medicine in otolaryngology? This question inquires about our literature, attitudes and capabilities, patients' desires. Thus, this installment "Evidence-Based Medicine Otolaryngology" focuses on these 3 topics. First, authors consider literature relative to benchmarks for study design. Second, data regarding otolaryngologists' other surgical specialists' understanding clinical are discussed. Third, patient-based efforts promote participate practice...

Depth-resolved label-free optical imaging by the method of multiphoton autofluorescence microscopy (MPAM) may offer new ways to examine cellular and extracellular atypia associated with epithelial squamous cell carcinoma (SCC). MPAM was evaluated for its ability identify microstructural in head neck tissues from resected discarded tumor tissue. Three-dimensional image volumes were obtained floor mouth, tongue, larynx, then processed histology. micrographs qualitative metrics quantitative...

Abstract Background The availability of paid parental leave is an important factor for retention and wellness. experiences head neck surgeons with have never been reported. Methods A survey was electronically distributed to subspecialty in the United States. Responses were collected analyzed. Results Male had more children took significantly less than women. Thirty percent respondents reported that negatively impacted compensation, 14% a delay promotion due leave, which women men. vast...

Objective To determine the risks of bleeding and other complications in pediatric patients who require noninvasive positive pressure ventilation (PPV) immediate posttonsillectomy period. Study Design Case series with chart review. Setting Single tertiary hospital. Subjects Methods Sixty-nine had undergone tonsillectomy from July 2007 through December 2013 required postoperative PPV were reviewed. Data collected included age, sex, medical history, preoperative polysomnogram parameters, length...

Abstract Combined large cell neuroendocrine carcinoma (LCNEC) and squamous (SCC) of the H&N are exceptionally rare. We present case combined p16 negative SCC LCNEC oropharynx treated with combination chemotherapy. This is third reported oropharynx.

Medical honey has been recognized for its medicinal properties thousands of years, and several medical products have entered the market over last two decades. In vitro studies shown that antimicrobial properties, protects against bacterial growth, improves wound healing. However, these are not widely used treatment in head neck surgery. Additionally, utilized those undergoing radiotherapy cancer (HNC) to treat radiation-induced mucositis. This literature review aims describe assess utility...

Background: Liposarcomas originating in the supraclavicular fossa are exceptionally rare, with only a few documented cases medical literature. Methods: We present unique case involving remarkably large indolent, atypical lipomatous tumor or well-differentiated liposarcoma situated right region, measuring 18 cm × 17 cm. To our knowledge, this represents largest found reported This highlights effective management of through complete surgical resection. Result and Conclusion: Our findings...

Background: Targeted therapies like denosumab have revolutionized multiple myeloma (MM) treatment, improved patient outcomes while introducing long-term complications. This study explores a rare instance of delayed maxillary osteonecrosis post-denosumab therapy, delving into its pathophysiology and management. Methods: A 40-year-old male MM who developed painful palatal lesion post treatment diagnosed by computed tomography scan surgical biopsy is presented. Treatment history, symptom...

Purpose Compared to insured individuals who have established pathways for primary and specialist care, uninsured patients often delay seeking medical attention are more likely rely on emergency departments or community clinics low-cost services. This study aims identify the most prevalent otolaryngology (ENT) diagnoses at a free, student-run clinic patients. Additionally, it seeks elucidate their management needs in order inform strategies enhancing support care this vulnerable population....

Abstract Objective To evaluate the trends in opioid and nonopioid prescribing for thyroidectomy parathyroidectomy before after publication of guidelines by American Academy Otolaryngology–Head Neck Surgery April 2021. Study Design Retrospective. Setting Eighty‐three health care organizations United States that contribute to TriNetX database. Methods Deidentified patient data were retrieved from TriNetX. Patients who prescribed either opioids or analgesic within 1 5 days following thyroid...