A5005177756- Radiation Therapy and Dosimetry
- Atomic and Molecular Physics
- X-ray Spectroscopy and Fluorescence Analysis
- Electron and X-Ray Spectroscopy Techniques
- Nuclear physics research studies
- Ion-surface interactions and analysis
- Nuclear Physics and Applications
- Quantum Chromodynamics and Particle Interactions
- DNA Repair Mechanisms
- Mass Spectrometry Techniques and Applications
- Radiation Effects in Electronics
- Radiation Effects and Dosimetry
- High-Energy Particle Collisions Research
- Radiation Shielding Materials Analysis
- Advanced NMR Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Advanced Chemical Physics Studies
- Effects of Radiation Exposure
- Railway Engineering and Dynamics
- Particle physics theoretical and experimental studies
- Plant Genetic and Mutation Studies
- Spectroscopy and Quantum Chemical Studies
- Muon and positron interactions and applications
- Advanced Radiotherapy Techniques
- Rare-earth and actinide compounds
East Carolina University
2013-2023
Greenville College
2021
Universitat de Barcelona
2001-2011
Kansas State University
2009
GTx (United States)
1999
University of Tübingen
1994-1997
Abstract Track structures and resulting DNA damage in human cells have been simulated for hydrogen, helium, carbon, nitrogen, oxygen neon ions with 0.25–256 MeV/u energy. The needed ion interaction cross sections scaled from those of hydrogen; Barkas scaling formula has refined, extending its applicability down to about 10 keV/u, validated against established stopping power data. Linear energy transfer (LET) scored deposits a cell nucleus; very low-energy ions, it defined locally within thin...
Friedland, W., Jacob, P., Bernhardt, Paretzke, H. G. and Dingfelder, M. Simulation of DNA Damage after Proton Irradiation. Radiat. Res. 159, 401–410 (2003).The biophysical radiation track simulation model PARTRAC was improved by implementing new interaction cross sections for protons in water. Computer-simulated tracks energy deposition events from their secondary electrons were superimposed on a higher-order target describing the spatial coordinates whole genome inside human cell. Induction...
Dingfelder, M., Ritchie, R. H., Turner, J. E., Friedland, W., Paretzke, H. G. and Hamm, N. Comparisons of Calculations with PARTRAC NOREC: Transport Electrons in Liquid Water. Radiat. Res. 169, 584–594 (2008).Monte Carlo computer models that simulate the detailed, event-by-event transport electrons liquid water are valuable for interpretation understanding findings radiation chemistry biology. Because paucity experimental data, such efforts must rely on theoretical principles considerable...
Our understanding of radiation induced cellular damage has greatly improved over the past decades. Despite this progress, there are still many obstacles to fully how interacts with biologically relevant components form observable endpoints. One hurdle is difficulty faced by members different research groups in directly comparing results. Multiple Monte Carlo codes have been developed simulate induction at DNA scale, while same time various models that describe repair processes varying levels...
The relativistic distorted-wave Born approximation is used to calculate differential and total cross sections for inner shell ionization of neutral atoms by electron positron impact. target atom described within the independent-electron using self-consistent Dirac-Fock-Slater potential. distorting potential projectile also set equal For electrons, this guarantees orthogonality all orbitals involved simplifies calculation exchange T-matrix elements. interaction between electrons assumed...
Space and cosmic radiation is characterized by energetic heavy ions of high linear energy transfer (LET). Although both low- high-LET radiations can create oxidative clustered DNA lesions double-strand breaks (DSBs), the local complexity tends to increase with increasing LET. We irradiated 28SC human monocytes doses from 0-10 Gy (56)Fe (1.046 GeV/ nucleon, LET = 148 keV/microm) determined induction processing prompt DSBs using pulsed-field gel electrophoresis (PFGE) Number Average Length...
Journal Article Simulation of DNA Damage after Proton and Low LET Irradiation Get access W. Friedland, Friedland Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Bernhardt, Bernhardt Jacob, Jacob H. G. Paretzke Radiation Protection Dosimetry, Volume 99, Issue 1-4, 1 June 2002, Pages 99–102, https://doi.org/10.1093/oxfordjournals.rpd.a006848 Published: 01 2002
Absolute doubly differential electron emission yields were measured from thin films of amorphous solid water (ASW) after the transmission 6 MeV protons and 19 (1 MeV/nucleon) fluorine ions. The ASW frozen on (1-µm) copper foils cooled to approximately 50 K. Electrons emitted detected as a function angle in both forward backward direction film thickness. Electron energies determined by measuring ejected time flight, technique that optimizes accuracy low-energy yields, where effects molecular...
Interaction cross sections for bare heavy charged (HZE) particles are obtained from proton interaction by scaling laws. Proton calculated within the (relativistic) plane wave Born approximation and modelled dielectric response function of liquid water. Relativistic polarisation effects (Fermi density effect) discussed. The model is implemented into biophysical track structure simulation code PARTRAC.
Radiation damage by low-energy ions significantly contributes to the high biological efficiency of ion beams in distal Bragg peak regions as well energy-dependent neutron irradiation. To enable assessing effects at energies <1 MeV u−1 with track-structure based models, a Barkas-like scaling procedure is developed that provides cross sections liquid water on those for hydrogen ions. The resulting stopping power and range carbon agree ICRU 73 database other data. method represents basis...