Purpose: Urgency urinary incontinence (UUI) is a common finding in patients with history of stroke or cerebrovascular accident (CVA). UUI associated impaired quality life as well increased morbidity, mortality, and need for institutionalization. Medical therapy often limited by side effects and/or cost prohibitiveness. As result, third-line implemented. The objective to determine the efficacy sacral neuromodulation (SNM) onabotulinum toxin (BTX) management post-CVA UUI.Methods: Retrospective...

Stress urinary incontinence (SUI) is common among adult women with negative effects on psychosocial well-being, mental health, and health-related quality of life. The purpose the research to determine if SUI in a factor implicated changes life (HRQoL) both physical health domains work difficulties.Data 40 years or older from cross-sectional, population-based, internet survey were examined post-hoc. effect frequency HRQoL (SF12 score), domains, was assessed. In addition, multivariate...

Abstract Aims The Joint Asia Diabetes Evaluation (JADE) Program is the first web‐based program incorporating a comprehensive risk engine, care protocols, clinical decision and self‐management support to improve ambulatory diabetes care. aim was validate stratification system of JADE using large prospective cohort. Methods interactive engine stratifies patients into different levels results from an annual assessment complications factors. We used registry consisting 7534 Type 2 diabetic...

Ureteral obstruction caused by extrinsic compression is often associated with intra-abdominal cancers. Internal drainage ureteral stents typically the first-line therapy to relieve such obstructions. Novel designs of made different materials have been invented achieve better drainage. In this study, we described functional outcomes a Resonance metallic stent (Cook Medical, Bloomington, Indiana, USA) in patients malignant and compare duration regular polymeric same cohort.Cancer who received...

Abstract Renal cell carcinoma (RCC) is a prevalent form of kidney cancer with high mortality rate, especially in advanced stages. While treatments like tyrosine kinase inhibitors, mTOR and immune checkpoint inhibitors exist, they often have limited efficacy. Temsirolimus, clinically used inhibitor, provides therapeutic option for RCC by hindering growth proliferation, but resistance to this drug can emerge. This study investigated the role deubiquitylating enzymes UCHL5/USP14 progression...

To provide clinical outcomes of the Resonance metallic ureteral stent in patients with malignant obstruction, as well factors predicting failure.Cancer who have received stents from July 2009 to March 2012 for obstruction were included chart review. Stent failure was detected by symptoms, image studies, and renal function tests. Survival analysis duration used estimate patency rate failure.A total 117 inserted successfully into 94 units 79 patients. There no major complications. These...

After chemotherapy for the treatment of metastatic bladder urothelial carcinoma (UC), most patients inevitably encounter drug resistance and resultant failure. Deubiquitinating enzymes (DUBs) remove ubiquitin from target proteins play a critical role in maintaining protein homeostasis. This study investigated antitumor effect PR-619, DUBs inhibitor, combination with cisplatin, UC treatment. Our results showed that PR-619 effectively induced dose- time-dependent cytotoxicity, apoptosis,...

Trichostatin A (TSA), an antifungal antibiotic derived from Streptomyces, inhibits mammalian histone deacetylases, and especially, selectively class I II deacetylase (HDAC) families of enzymes. TSA reportedly elicits antiproliferative response in multifarious tumors. This study investigated the antitumor effects alone combination with paclitaxel when applied to two high-grade urothelial carcinoma (UC) cell lines (BFTC-905 BFTC-909). Fluorescence-activated sorting, flow cytometry,...

Cisplatin-based chemotherapy is the primary treatment for metastatic bladder urothelial carcinoma (UC). Most patients inevitably encounter drug resistance and resultant disease relapse. Reduced apoptosis plays a critical role in chemoresistance. Trifluoperazine (TFP), an antipsychotic agent, has demonstrated antitumor effects on various cancers. This study investigated efficacy of TFP inhibiting cisplatin-resistant UC explored underlying mechanism. Our results revealed that cells (T24/R)...

Abstract Background Hyperglycemia is associated with series of process leading to oncogenesis. Evidence has shown that diabetes mellitus (DM) seems be poor prognosis in patients bladder cancer. However, evidence on the effect glycemic control outcomes cancer still limited. In current study, we aimed investigate DM and Methods We conducted a retrospective chart review prospective database from January 2012 December 2017. Patients newly diagnosed non-muscle invasive (NMIBC) were included. They...

While nocturia has been proposed to be related various systemic diseases and even mortality, there little information of the impact in other aspects physical mental well-being. We evaluated on quality life (QoL), health, work limitation, health-care seeking behavior.An internet-based self-administered survey was distributed among individuals aged ≥40 years with ability use a computer read local language. Survey questions included demographic details, International Continence Society symptom...

Urothelial carcinoma (UC) comprises the majority of bladder cancers. Standard platinum-based chemotherapy has a response rate approximately 50%, but drug resistance develops after short-term treatment. Deubiquitinating (DUB) enzyme inhibitors increase protein polyubiquitination and endoplasmic reticulum (ER) stress, which might further suppress cancer stemness overcome cisplatin resistance. Therefore, we investigated cytotoxic effect potential mechanisms b-AP15 on urothelial carcinoma. Our...

The gp120 envelope glycoprotein of human immunodeficiency virus type 1 binds the cell surface protein CD4 with high affinity. Here we report use proteolysis to define regions involved in binding. Cleavage Staphylococcus aureus V8 protease at residue 269 or trypsin 432 destroys These same sites are protected from proteolytic cleavage by bound CD4. Cleavages 64, 144, 166, 172, and 315 do not affect binding CD4, indicating that these critical for All fragments found coprecipitates were...

Objective To investigate the outcomes of artificial urinary sphincter (AUS) placement in patients with post‐prostatectomy incontinence (PPUI) or without a prior male sling. Patients and Methods We performed retrospective chart review who underwent AUS for PPUI from 2007 to 2022. The primary endpoint was determine proportion achieved social continence, defined as self‐reported use 0–1 pad/day. secondary endpoints were device failure rates failure‐free survival. Results analysis included 210...

RP215 monoclonal antibody (Mab) was shown to recognize a specific carbohydrate-associated epitope found in cancer cell-expressed glycoproteins, known as CA215. The membrane-bound and soluble forms of CA215 were detected almost all the cells humans, but rarely normal tissues. Through MALDI-TOF MS analysis, it has been reported previously that much 40% tryptic peptides showed high degrees sequence homology those immunoglobulin heavy chains. cell-derived immunoglobulins further purified from by...

Male urinary incontinence (UI) is a global health issue associated with bothersome symptoms which affect daily life. This study aims to evaluate the prevalence of male UI in China, Taiwan, and South Korea determine if an independent risk factor affecting health-related quality life (HRQoL), mental health, work limitations, healthcare seeking behavior.A post-hoc analysis was conducted on LUTS Asia database collated from cross-sectional, population-based internet survey Korea. Prevalence...

Introduction: We provide primary patency rate of metallic ureteral stents in cancer patients and investigate the factors affecting patency. Methods: All who had received for malignant obstruction between July 2009 November 2012 our institute were included. No excluded. Patient profiles, imaging studies, laboratory data collected. profiles included age, gender, body height, weight, mass index, types, treatment cancer, response to treatment, methods stent insertion, prior ordinary stents....

Cancer cells rely on aberrant transcription for growth and survival. Cyclin-dependent kinases (CDKs) play critical roles in regulating gene by modulating the activity of RNA polymerase II (RNAPII). THZ1, a selective covalent inhibitor CDK7, has antitumor effects several human cancers. In this study, we investigated role therapeutic potential CDK7 angiogenic endothelial renal cell carcinoma (RCC). Our results revealed that vascular factor (VEGF), activator angiogenesis, upregulated expression...

Abstract To compare clinical outcomes between the use of robotic-assisted laparoscopic radical prostatectomy (RP) and radiotherapy (RT) with long-term androgen deprivation therapy (ADT) in locally advanced prostate cancer (PC), 315 patients PC (clinical T-stage 3/4) were considered for analysis retrospectively. Propensity score-matching at a 1:1 ratio was performed. The median follow-up period 59.2 months (IQR 39.8–87.4). There 117 (37.1%) RP group 198 (62.9%) RT group. older had higher PSA...