A5050904672- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Ophthalmology and Visual Impairment Studies
- Neurological diseases and metabolism
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Health disparities and outcomes
- Peripheral Neuropathies and Disorders
- Retinal Diseases and Treatments
- Physical Activity and Health
- Hereditary Neurological Disorders
- Psychological Well-being and Life Satisfaction
- Sleep and related disorders
- Pharmacological Effects and Toxicity Studies
- Peripheral Nerve Disorders
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Electrochemical Analysis and Applications
- Sleep and Wakefulness Research
- Ion channel regulation and function
- Motor Control and Adaptation
- Biochemical Acid Research Studies
First Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Xi'an Jiaotong University
2014
University of California, San Francisco
2008
The coronavirus (COVID-19) pandemic has impacted education systems globally, making digital devices common arrangements for adolescent learning. However, vision consequences of such behavioral changes are not well-understood. This study investigates the association between duration daily screen engagement and myopic progression among 3,831 Chinese adolescents during COVID-19 pandemic. Study subjects report an average 2.70 ( SD = 1.77), 3.88 2.23), 3.58 2.30), 3.42 2.49) hours television,...
The coronavirus disease 2019 (COVID-19) pandemic forced many education systems to consider alternative remote e-learning modalities, which have consequential behavioral and health implications for youth. In particular, increased engagement with digital screens reduction in outdoor activities are two likely channels posing adverse risks myopia development. This study investigated the association between screen use, activity, lighting condition, development among school-age children China,...
Emotional blunting and abnormal processing of rewards punishments represent early features frontotemporal lobar degeneration (FTLD). Better understanding the physiological underpinnings these emotional changes can be facilitated by use classical psychology approaches. Fear conditioning (FC) is an extensively used paradigm for studying that has rarely been applied to study dementia. We studied FC in controls (n = 25), Alzheimer's disease 25) FTLD 25). A neutral stimulus (coloured square on a...
Background Around the globe, various self-quarantine, social distancing, and school-closure policies were implemented during coronavirus disease-19 (COVID-19) outbreak to reduce disease transmission.Many economies/territories compelled consider digital learning modalities.In particular, increased engagement with devices mounting psychosocial stress due isolation are likely pose adverse risks for youth visual health globally.This study examines association between device use, stress, myopia...
This study examines the extent to which depressive symptoms mediate link between physical activity and cognitive function among older adults in China.This utilizes 2013-18 China Health Retirement Longitudinal Study (CHARLS) dataset, of 3,658 subjects over age 50 satisfied inclusion criteria. Degree activity, prevalence symptoms, performance are measured by International Physical Activity Questionnaire (IPAQ), Center for Epidemiological Studies Depression Scale (CESD), Mini-Mental State...
Amyotrophic lateral sclerosis is an unremitting neurodegenerative (ND) disease characterized by progressive and fatal loss of motor neuron function. While underlying mechanisms for ALS susceptibility are complex, current understanding suggests that interactions between age, genetic, environmental factors may be the key. Environmental exposure to metal/metalloids has been implicated in various ND diseases including ALS, Alzheimer's Disease (AD), Parkinson's (PD). However, most currently...
Importance Tetramethylpyrazine nitrone has exhibited promising results in improving motor dysfunction neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Objective To evaluate the safety and efficacy of orally administered tetramethylpyrazine patients with ALS. Design, Setting, Participants This phase 2, multicenter, double-masked, placebo-controlled, randomized clinical trial was conducted from December 24, 2020, through July 14, 2023, 11 centers China, a 180-day...
Conflicting findings have been reported regarding the lateralized brain abnormality in patients with amyotrophic lateral sclerosis (ALS). In this study, we aimed to investigate probable lateralization of gray matter (GM) atrophy ALS patients. We focused on relationship between asymmetry decreased GM volume and side disease onset limb-onset. Structural imaging evaluation normalized (SIENAX) voxel-based morphometry (VBM) were used assess differences global local regions heterogeneous body...
Abstract Background Despite effectiveness in delaying the spread of pandemic, frequent and extended disruption to children’s livelihoods have fomented new norms which learning routines encounter immense change. In particular, increased sedentary e-learning engagement with electronic screens exposure stressful circumstances are likely pose adverse risks for vision development. Methods This present study examines link between near-sighted refractive error, screens, psychosocial stress level,...
A plethora of environmental risk factors has been persistently implicated in the pathogenesis amyotrophic lateral sclerosis (ALS), including metal/metalloids. This study aimed to examine potential associations between cerebral spinal fluid (CSF) metal/metalloids and ALS risks. CSF concentrations copper (Cu), nickel (Ni), mercury (Hg), arsenic (As), manganese (Mn), iron (Fe) (spinal- bulbar-onset) patients controls were measured using inductively coupled plasma mass spectrometry (ICP-MS)....
Abstract To comprehensively assess whether p75 ECD in urine could be a candidate biomarker for ALS evaluation. Urine samples were collected from 101 patients, 108 patients with other neurological disease (OND) and 97 healthy controls. 61 followed up clinical data including ALSFRS-r every 6 to 12 months, 23 died 17 lost touch during follow period. Enzyme-linked immunoassay was employed determine concentration. The the severity of ALS. concentration significantly higher than that OND CTRL (p...
Purpose: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive loss of motor neurons, but it increasingly recognized to be more disseminated disease. The literature on the involvement sympathetic skin response (SSR) in ALS few. Methods: We reviewed with specific emphasis SSR and investigated 120 patients sporadic 130 age-matched healthy subjects determine effects patients. was conducted all subjects. Results: found prolonged mean latency patients,...
The brainstem is an important component in the pathology of amyotrophic lateral sclerosis (ALS). Although neuroimaging studies have shown multiple structural changes ALS patients, few investigated alterations brainstem. Herein, we compared structure between patients with and healthy controls.A total 33 controls were recruited this study. T1-weighted diffusion tensor imaging (DTI) acquired on a 3 Tesla magnetic resonance (3T MRI) scanner. Volumetric vertex-wised approaches implemented to...
<b><i>Purpose:</i></b> The diagnosis of Guillain-Barre syndrome (GBS) in the very early stage may be challenging. Our aim was to report neurophysiological abnormalities GBS within 4 days clinical onset. We expected that will diagnosed by assistance study stage. <b><i>Methods:</i></b> prospectively recruited patients with a discharged from First Affiliated Hospital Xi’an Jiaotong University and Xi Jing Hospital. Patients were classified into 3...
Abstract To explore differential diagnosis value of dissociated lower-limb muscle impairment, we performed a retrospective analysis clinical and electrophysiological features in 141 involved ALS patients, 218 normal controls, 67 disease 32 lumbar spondylosis patients. The impairment was quantified by plantar flexion dorsiflexion strength, compound action potentials ratio peroneal tibial nerves (split index, SI) semi-quantitative scoring scale denervation potential. Clinical features: the...
To identify differential metabolites and metabolic pathways provide guidance for the novel biomarkers diagnosis prognosis of amyotrophic lateral sclerosis (ALS). ALS patients people without nervous diseases were recruited. Metabolomic analysis was performed using gas chromatography-mass spectrometry (GC/MS). The orthogonal projections to latent structures discriminant (OPLS-DA) used metabolites. Kyoto Encyclopedia Genes Genomes MetaboAnalyst pathways. 75 detected aligned. OPLS-DA showed...
The early clinical features of nitrous oxide (N2 O)-induced neuropathy were mimicking that Guillain-Barré syndrome (GBS). We aimed to explore and laboratory characteristics N2 O-induced in comparison with GBS. retrospectively reviewed data 15 patients compared them GBS patients. age the group was significantly younger than (22 ± 5 vs 45 17). Paresthesia more common (100% 53.3%). proportion distal upper limbs weakness lower (20.0% 93.3%). There no significant difference 80.0%). incidence...
Abstract Aims This multicenter, open‐label, randomized study (Registration No. ChiCTR‐OCH‐14004528) aimed to compare the efficacy and effects of oxcarbazepine (OXC) with levetiracetam (LEV) as monotherapies on patient quality life mental health for patients newly diagnosed focal epilepsy from China. Methods Patients who had experienced 2 or more unprovoked seizures at greater than a 24‐h interval during previous year were recruited. Participants randomly assigned OXC group LEV group....
Photosensitive is probably caused by multiple factors including gender, familiar, etc. We aim to study the clinical and EEG features of Chinese Han patients with photosensitivity. A total 5482 consecutive possible epilepsy from 3 center in China. Of 73 PPR IPS, 48 were female. 69.9% evoked frequency ranged 8 Hz-25 Hz, accompanying seizures 13 patients. 6 9 eyes closure sensitivity experienced epileptic during IPS. found some new features: 1) The apt experience electro-clinical provoked IPS;...
Abstract The aim of this study was to localize the anatomic distribution upper motor neuron (UMN) loss through examining cortical thickness at clinical onset amyotrophic lateral sclerosis (ALS) and explore manifestation in functionally impaired body region attribute impairment lower (LMN) or UMN mixed LMN UMN? features, corresponding areas from different regions MRI electromyography (EMG) data were collected 108 classical ALS patients. thinner group than control bilateral head-face...
The reference values of long exercise test are inconsistent in previous studies. Our research aims to determine the and improve diagnostic efficiency periodic paralysis.In this study, 100 healthy controls, 35 non-periodic paralysis patients, 47 patients with were recruited. procedures conducted following McMannis(1986) method.The decrease rate compound muscle action potential amplitudes was correlated gender, it not influenced by age, height, weight, exercise. After analyzing receiver...