A5070152440- Genetics, Aging, and Longevity in Model Organisms
- Genetic and Kidney Cyst Diseases
- Cholinesterase and Neurodegenerative Diseases
- Biochemical effects in animals
- Circadian rhythm and melatonin
- Biomedical Research and Pathophysiology
- Epigenetics and DNA Methylation
Seoul National University
2016-2022
Membrane integrity is critical for cell survival, defects of which cause pathological symptoms such as metabolic diseases. In this study, we used ethanol sensitivity the nematode Caenorhabditis elegans to identify genetic factors involved in membrane integrity. InC. elegans, acute exposure a high concentration (7% v/v) changes permeability, measured by propidium iodide staining, and causes paralysis. We timing complete paralysis an indicator alteration our screen, identified ptr-6 gene that...
Cilia are important for the interaction with environments and proper function of tissues. While basic structure cilia is well conserved, ciliated cells have various functions. To understand distinctive identities cells, identification cell-specific proteins its regulation essential. Here, we report mechanism that confers a specific identity on IL2 neurons in Caenorhabditis elegans, dauer larva-specific nictation behavior. We show DAF-19M, an isoform sole C. elegans RFX transcription factor...
Abstract Animals exhibit phenotypic plasticity through the interaction of genes with environment, and little is known about genetic factors that change synaptic function at different developmental stages. Here, we investigated determinants how stages alter transmission using free-living nematode Caenorhabditis elegans. C. elegans enters stress-resistant dauer larval stage under harsh conditions. Although to have reduced permeability increased resistance most exogenous chemicals, discovered...
Abstract Animals exhibit phenotypic plasticity through the interaction of genes with environment, and little is known about genetic factors that change synaptic function at different developmental stages. Here, we investigated determinants how animal’s sensitivity to drugs alter activity regulated a specific stage using free-living nematode Caenorhabditis elegans. C. elegans enters stress-resistant dauer larval under harsh conditions. Although have reduced permeability increased resistance...
Abstract In animals, cilia are important for the interaction with environments and proper function of tissues organs. Understanding distinctive identities each type ciliated cell is essential therapeutic solutions ciliopathies, complex disorders impairments various organs caused by defective development function. Here, we report a regulatory module consisting cascade transcription factors their target genes that confer type-specific ciliary on IL2 neurons in C. elegans . We found DAF-19M,...
In animals, cilia are important for the interaction with environments and proper function of tissues organs. While basic structure is well conserved, ciliated cells have a variety functions. To understand distinctive identities each type cell, identification cell-specific proteins their regulation essential. Here, we report mechanism that confers specific identity on IL2 neurons in C. elegans, dauer larva-specific nictation behavior. We show DAF-19M, an isoform sole elegans RFX transcription...