A5079317662- Genetics, Aging, and Longevity in Model Organisms
- Telomeres, Telomerase, and Senescence
- Biochemical effects in animals
- Cholinesterase and Neurodegenerative Diseases
- CRISPR and Genetic Engineering
- Mitochondrial Function and Pathology
- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Parasitic Diseases Research and Treatment
- Chromosomal and Genetic Variations
Seoul National University
2015-2025
Abstract Telomeres, the nucleoprotein complexes that protect ends of linear chromosomes, are essential for maintaining stability eukaryotic genomes. As telomeres generally consist repetitive DNA associated with specifically bound proteins, telomeric repeat motifs (TRMs) thought to be difficult evolve. However, a recent study identified nematodes repeats distinct from canonical TTAGGC motif. Here, we investigated how telomere could have evolved despite challenge posed by specificity...
Cells surviving crisis are often tumorigenic and their telomeres commonly maintained through the reactivation of telomerase. However, cells occasionally activate a recombination-based mechanism called alternative lengthening (ALT). Here we establish stably survivors in telomerase-deleted Caenorhabditis elegans that escape from sterility by activating ALT. ALT trans-duplicate an internal genomic region, which is already cis-duplicated to chromosome ends, across all chromosomes. These...
Abstract Telomeres, the nucleoprotein complexes that protect ends of linear chromosomes, are essential for maintaining stability eukaryotic genomes. As telomeres generally consist repetitive DNA associated with specifically bound proteins, telomeric repeat motifs (TRMs) thought to be difficult evolve. However, a recent study identified nematodes repeats distinct from canonical TTAGGC motif. Here, we investigated how telomere could have evolved despite challenge posed by specificity...
Abstract Under adverse environmental conditions, nematodes arrest into dauer, an alternative developmental stage for diapause. Dauer endures unfavorable environments and interacts with host animals to access favorable environments, thus playing a critical role in survival. Here, we report that Caenorhabditis elegans , daf-42 is essential development the dauer stage, as null mutant of exhibited “no viable dauer” phenotype which no dauers were obtained any dauer-inducing conditions. Long-term...
Abstract Under adverse environmental conditions, nematodes arrest into dauer, an alternative developmental stage for diapause. Dauer endures unfavorable environments and interacts with host animals to access favorable environments, thus playing a critical role in survival. Here, we report that Caenorhabditis elegans, daf-42 is essential development the dauer stage, as null mutant of exhibited “no viable dauer” phenotype which no dauers were obtained any dauer-inducing conditions. Long-term...
Abstract Animals exhibit phenotypic plasticity through the interaction of genes with environment, and little is known about genetic factors that change synaptic function at different developmental stages. Here, we investigated determinants how stages alter transmission using free-living nematode Caenorhabditis elegans. C. elegans enters stress-resistant dauer larval stage under harsh conditions. Although to have reduced permeability increased resistance most exogenous chemicals, discovered...
Abstract Animals exhibit phenotypic plasticity through the interaction of genes with environment, and little is known about genetic factors that change synaptic function at different developmental stages. Here, we investigated determinants how animal’s sensitivity to drugs alter activity regulated a specific stage using free-living nematode Caenorhabditis elegans. C. elegans enters stress-resistant dauer larval under harsh conditions. Although have reduced permeability increased resistance...